Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | TsxAB/Xre(antitoxin) |
| Location | 7028..7529 | Replicon | plasmid unnamed3 |
| Accession | NZ_CP055102 | ||
| Organism | Shigella flexneri strain SWHIN_107 | ||
Toxin (Protein)
| Gene name | TsxA | Uniprot ID | H1ZXU8 |
| Locus tag | HUZ84_RS24860 | Protein ID | WP_000702247.1 |
| Coordinates | 7028..7288 (+) | Length | 87 a.a. |
Antitoxin (Protein)
| Gene name | TsxB | Uniprot ID | - |
| Locus tag | HUZ84_RS24865 | Protein ID | WP_001132407.1 |
| Coordinates | 7278..7529 (+) | Length | 84 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| HUZ84_RS24815 | 2570..2722 | + | 153 | Protein_2 | DUF5431 family protein | - |
| HUZ84_RS24820 (HUZ84_24605) | 2667..2789 | + | 123 | WP_223170659.1 | type I toxin-antitoxin system Hok family toxin | - |
| HUZ84_RS24825 (HUZ84_24610) | 2939..3535 | + | 597 | WP_000125165.1 | ProQ/FINO family protein | - |
| HUZ84_RS24830 | 3553..3837 | - | 285 | WP_001162371.1 | hypothetical protein | - |
| HUZ84_RS24835 (HUZ84_24620) | 3911..4576 | - | 666 | WP_000532149.1 | division plane positioning ATPase MipZ | - |
| HUZ84_RS24840 (HUZ84_24625) | 5174..5503 | + | 330 | WP_000855121.1 | hypothetical protein | - |
| HUZ84_RS24845 (HUZ84_24630) | 6082..6405 | + | 324 | WP_000427402.1 | hypothetical protein | - |
| HUZ84_RS24850 (HUZ84_24635) | 6446..6655 | + | 210 | WP_000866036.1 | hypothetical protein | - |
| HUZ84_RS24855 (HUZ84_24640) | 6752..6976 | + | 225 | WP_000814381.1 | hypothetical protein | - |
| HUZ84_RS24860 (HUZ84_24645) | 7028..7288 | + | 261 | WP_000702247.1 | hypothetical protein | Toxin |
| HUZ84_RS24865 (HUZ84_24650) | 7278..7529 | + | 252 | WP_001132407.1 | transcriptional regulator | Antitoxin |
| HUZ84_RS24870 (HUZ84_24655) | 8079..8357 | + | 279 | WP_000545938.1 | hypothetical protein | - |
| HUZ84_RS24875 (HUZ84_24660) | 8822..9070 | + | 249 | WP_000513532.1 | type II toxin-antitoxin system HicA family toxin | - |
| HUZ84_RS24880 (HUZ84_24665) | 9067..9414 | + | 348 | WP_000681609.1 | type II toxin-antitoxin system HicB family antitoxin | - |
| HUZ84_RS24885 | 9502..9945 | - | 444 | WP_023223351.1 | hypothetical protein | - |
| HUZ84_RS24890 (HUZ84_24675) | 10186..10485 | + | 300 | WP_034169410.1 | type II toxin-antitoxin system HicB family antitoxin | - |
| HUZ84_RS24895 (HUZ84_24680) | 10745..11071 | - | 327 | WP_000206697.1 | hypothetical protein | - |
| HUZ84_RS24900 (HUZ84_24685) | 11073..11411 | - | 339 | WP_029797038.1 | hypothetical protein | - |
| HUZ84_RS24905 | 11391..11513 | - | 123 | Protein_20 | hypothetical protein | - |
| HUZ84_RS24910 (HUZ84_24690) | 11533..12240 | - | 708 | WP_000108794.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Mobilizable plasmid | - | - | 1..58696 | 58696 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 87 a.a. Molecular weight: 9817.29 Da Isoelectric Point: 10.0665
>T161520 WP_000702247.1 NZ_CP055102:7028-7288 [Shigella flexneri]
MKIRKGDRQYYLNKEGDTFHLVKRVKTFSKSATLGKTKATVKTVADLVFHEKAFDTIDFASDGLRENDKEIVSMMIQEMS
EGKNAK
MKIRKGDRQYYLNKEGDTFHLVKRVKTFSKSATLGKTKATVKTVADLVFHEKAFDTIDFASDGLRENDKEIVSMMIQEMS
EGKNAK
Download Length: 261 bp
>T161520 NZ_CP071210:c3109567-3109169 [Serratia marcescens subsp. marcescens ATCC 13880]
ATGTTCAGTCATATGCTGGACACCAACATTGTTATCTATGTCATCAAGCGCCGGCCGCTGGAAGTGCTGGAGGCATTCAA
TCGCTATGCAGGTAAAATGGTCATTTCGTCGATCACTTATGGCGAATTGGTTCACGGGGTGGAGAAAAGCGCTCGTCCAG
CGGTGAACGCCAGAGTCGTTGAGGATTTTGTCTCCCGATTGGACATTCTCGATTACAGCGCCAAAGCGGCATCGCACTAC
GGCAATATCCGGGCTGCGCTGGAACGACAGGGAACGCCTATTGGCGTAAACGATCTACATATTGCCGGGCATGCGCGCAG
CGAAGGATTGATCCTGGTGACCAATAATCGACGCGAATTTGAGCGCGTTGAGGGTTTGCGGCTGGAAAATTGGTTGTAA
ATGTTCAGTCATATGCTGGACACCAACATTGTTATCTATGTCATCAAGCGCCGGCCGCTGGAAGTGCTGGAGGCATTCAA
TCGCTATGCAGGTAAAATGGTCATTTCGTCGATCACTTATGGCGAATTGGTTCACGGGGTGGAGAAAAGCGCTCGTCCAG
CGGTGAACGCCAGAGTCGTTGAGGATTTTGTCTCCCGATTGGACATTCTCGATTACAGCGCCAAAGCGGCATCGCACTAC
GGCAATATCCGGGCTGCGCTGGAACGACAGGGAACGCCTATTGGCGTAAACGATCTACATATTGCCGGGCATGCGCGCAG
CGAAGGATTGATCCTGGTGACCAATAATCGACGCGAATTTGAGCGCGTTGAGGGTTTGCGGCTGGAAAATTGGTTGTAA
Antitoxin
Download Length: 84 a.a. Molecular weight: 9404.77 Da Isoelectric Point: 9.8120
>AT161520 WP_001132407.1 NZ_CP055102:7278-7529 [Shigella flexneri]
MPNENTPENIKRLRQKIGLTQKECAEIFSMSPRTWRRKEEPVGTASGTALTPVEFKFLLLLAGEHPDYVLCKRNKKNSDS
GSN
MPNENTPENIKRLRQKIGLTQKECAEIFSMSPRTWRRKEEPVGTASGTALTPVEFKFLLLLAGEHPDYVLCKRNKKNSDS
GSN
Download Length: 252 bp
>AT161520 NZ_CP071210:c3109800-3109567 [Serratia marcescens subsp. marcescens ATCC 13880]
ATGACGTTAGGTTCTGTCTTTACTAATAATCGGACACAGGCTGTACGCCTGCCTGCAGAGGCGCGTTTCCCTGATACCGT
TTCTAAAGTGACCGTTCGCGTAGTGGGTAAAGAGCGCATTCTTGCCCCCCTGGAGAATACCTGGGACAGTTTCTTCTGTG
CGGAAAATGAGGTGAGCGATGATTTTCTCAATGAACGTGCCGGACAGCACCAGCGCGAGCGGGAAGCGTTTTGA
ATGACGTTAGGTTCTGTCTTTACTAATAATCGGACACAGGCTGTACGCCTGCCTGCAGAGGCGCGTTTCCCTGATACCGT
TTCTAAAGTGACCGTTCGCGTAGTGGGTAAAGAGCGCATTCTTGCCCCCCTGGAGAATACCTGGGACAGTTTCTTCTGTG
CGGAAAATGAGGTGAGCGATGATTTTCTCAATGAACGTGCCGGACAGCACCAGCGCGAGCGGGAAGCGTTTTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|