Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 1324080..1324705 Replicon chromosome
Accession NZ_CP055099
Organism Shigella flexneri strain SWHIN_107

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag HUZ84_RS06365 Protein ID WP_000911330.1
Coordinates 1324307..1324705 (+) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID U9XQV3
Locus tag HUZ84_RS06360 Protein ID WP_000450524.1
Coordinates 1324080..1324307 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HUZ84_RS06335 (1319882) 1319882..1320352 - 471 WP_001068682.1 thioredoxin-dependent thiol peroxidase -
HUZ84_RS06340 (1320352) 1320352..1320924 - 573 WP_000176187.1 glycine cleavage system transcriptional repressor -
HUZ84_RS06345 (1321070) 1321070..1321948 + 879 WP_001295469.1 4-hydroxy-tetrahydrodipicolinate synthase -
HUZ84_RS06350 (1321965) 1321965..1322999 + 1035 WP_001297320.1 outer membrane protein assembly factor BamC -
HUZ84_RS06355 (1323212) 1323212..1323925 + 714 WP_001295467.1 phosphoribosylaminoimidazolesuccinocarboxamide synthase -
HUZ84_RS06360 (1324080) 1324080..1324307 + 228 WP_000450524.1 toxin-antitoxin system antitoxin VapB Antitoxin
HUZ84_RS06365 (1324307) 1324307..1324705 + 399 WP_000911330.1 type II toxin-antitoxin system VapC family toxin Toxin
HUZ84_RS06370 (1324852) 1324852..1325715 + 864 WP_001267507.1 neutral zinc metallopeptidase -
HUZ84_RS06375 (1325730) 1325730..1327745 + 2016 WP_032283657.1 tRNA cytosine(34) acetyltransferase TmcA -
HUZ84_RS06380 (1327819) 1327819..1328517 + 699 WP_000679823.1 esterase -
HUZ84_RS06385 (1328627) 1328627..1328827 - 201 WP_000383836.1 YpfN family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-125)

Antitoxin

SpoVT-AbrB domain

(7-52)


Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14894.25 Da        Isoelectric Point: 9.2216

>T161491 WP_000911330.1 NZ_CP055099:1324307-1324705 [Shigella flexneri]
MLKFMLDTNICIFTIKNKPVHVRERFNLNSGRMCISSVTLMELIYGAEKSQMPERNLAVIEGFVSRLVVLDYDSAAATHT
GQIRAELARQGRPVGPFDQMIAGHARSRGLIVVTNNTREFERVAGIRLEDWS

Download         Length: 399 bp

>T161491 NZ_CP071204:1601799-1602107 [Serratia marcescens subsp. marcescens ATCC 13880]
ATGCAATTTACCGTATATGACAATACGTATCCGGCATCAGCCTATCCCTACTTACTGGACGTTCAAAGCGATCTTATTGA
TGTCCTCTCGACCCGGTTAATGATCCCTCTTTATGCTTTGGATAATGTCAGGGTTAAAATTTCTGCACGTTTATGCCCGG
AGATTGAGGTCAACGGCGAAAAGTTTCTTGTTATGACGCATGAGATGGCTGCCGTACGTATTTCGCAGATTGGGAAGGCC
GTTGGTAATGTCAATGAGCACAGGAATCAAATTAAAGCCGCCATCGATTTTCTGATTGATGGTTTTTGA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8498.61 Da        Isoelectric Point: 4.3867

>AT161491 WP_000450524.1 NZ_CP055099:1324080-1324307 [Shigella flexneri]
METTVFLSNRSQAVRLPKAVALPEDVKKVEIIAIGRTRIITPAGESWDSWFDGENVSADFMDIRDQPAMQERESF

Download         Length: 228 bp

>AT161491 NZ_CP071204:1601560-1601796 [Serratia marcescens subsp. marcescens ATCC 13880]
ATGGCAAATAACAATGTGACGAAAAAGACAGTCAACGTAACCATCGATCGCGATCTTTTCCAGCGCGCAAAATCCCTGGG
CGTCAATGTGTCATCTGTATTGACGGACGCATTGAGCGTCCGTGTCAGGGACATTGAGATTCAACAGTGGCGCGAGCAAA
ATCGTGCGGCGTTAGAAGAACTTAATCGTATCACTGAAGAAAATGGTTTGTTGTCTGATGAATATCGGACATTTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A829CM33

References