Detailed information of TA system TA161483

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mosAT/AbiEii-AbiEi
• Location: 4832302..4833983
• Replicon: chromosome
• Accession: NZ_CP055096
• Organism: Klebsiella pneumoniae strain SWHIN_108

Toxin (Protein)

• Gene name: mosT
• Uniprot ID: J2XCI1
• Locus tag: HUZ85_RS23600
• Protein ID: WP_004146663.1
• Coordinates: 4832302..4833219 (-)
• Length: 306 a.a.

Antitoxin (Protein)

• Gene name: mosA
• Uniprot ID: -
• Locus tag: HUZ85_RS23605
• Protein ID: WP_032418188.1
• Coordinates: 4833225..4833983 (-)
• Length: 253 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HUZ85_RS23580 (4827608)	4827608..4829128	+	1521	WP_032418186.1	sugar ABC transporter ATP-binding protein	-
HUZ85_RS23585 (4829125)	4829125..4830123	+	999	WP_002885172.1	ribose ABC transporter permease	-
HUZ85_RS23590 (4830154)	4830154..4831095	+	942	WP_002885156.1	ABC transporter substrate-binding protein	-
HUZ85_RS23595 (4831170)	4831170..4832177	+	1008	WP_032418187.1	carbohydrate kinase family protein	-
HUZ85_RS23600 (4832302)	4832302..4833219	-	918	WP_004146663.1	nucleotidyl transferase AbiEii/AbiGii toxin family protein	Toxin
HUZ85_RS23605 (4833225)	4833225..4833983	-	759	WP_032418188.1	type IV toxin-antitoxin system AbiEi family antitoxin	Antitoxin
HUZ85_RS23610 (4834069)	4834069..4834797	-	729	WP_004210017.1	response regulator transcription factor	-
HUZ85_RS23615 (4835070)	4835070..4837217	+	2148	WP_077598926.1	formate dehydrogenase subunit alpha	-
HUZ85_RS23620 (4837214)	4837214..4837357	-	144	WP_022631365.1	hypothetical protein	-
HUZ85_RS23625 (4837563)	4837563..4838249	+	687	WP_004151733.1	tetratricopeptide repeat protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Nucleotidyl transferase AbiEii toxin, Type IV TA system (14-278)

Antitoxin

• Transcriptional regulator AbiEi antitoxin, N-terminal domain (1-93)

Sequences

Toxin

Protein

• Length: 306 a.a.
• Molecular weight: 34659.10 Da
• Isoelectric Point: 5.4707

>T161483 WP_004146663.1 NZ_CP055096:c4833219-4832302 [Klebsiella pneumoniae]
MDIQAPYYRQVALLMQVLPYVAVEREFALKGGTAINLFIRDFPRLSVDIDLAWVPLESRAIALPHIRDALARIAANLQQQ
AGMSAVLQANRSDEMRVIVTTDSAQIKIEVSPVARGTLYPPQEREVVGAVEDVFGYASLPVVSLPDLYGGKLCAALDRQH
PRDFYDVKLLLDAQELDRPIFNGFIAYLLSHNRPLAEVLNPRWKDIAEPFYREFSGMTFETIALEELTAVPNRMIAALKS
CFTQQDVDFLLSFKRGEPDWRLAPEMRIQDLPAVQWKLRNIHQMPAIKRAESLDKLEKVLAEWRS

Nucleotide

• Length: 918 bp

>T161483 NZ_CP071202:2039720-2039816 [Serratia marcescens subsp. marcescens ATCC 13880]
AACAAGCCCTGCATTAAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTAGACCGAATATAGGAATC
GTATTCGGTCTTTTTTT

Antitoxin

Protein

• Length: 253 a.a.
• Molecular weight: 28620.99 Da
• Isoelectric Point: 10.0001

>AT161483 WP_032418188.1 NZ_CP055096:c4833983-4833225 [Klebsiella pneumoniae]
MATKLNWLLQNSAPGDVILQSWLSQHAISPSLAFKYAQSGWLKKRGNGVYARAGREPEWNDALACLQNQLAAPVYVAGLS
SLVWQGRSHYLQLKQNQCWLSVENKALLPKWFREFPGVEWIVISGKKLPVLDDRYRVTLDIKGKKLIGSAPELAAYELLS
AVPETLSFNHAAELFQGLVNLNPRKVEYLLSVSQSVQAKRLYLFFASFYEHGWLKRIDSQKIDLGAGKRQIVENGKFNAQ
YQITVPERFQKE

Nucleotide

• Length: 759 bp

>AT161483 NZ_CP071202:c2039816-2039676 [Serratia marcescens subsp. marcescens ATCC 13880]
AAAAAAAGACCGAATACGATTCCTATATTCGGTCTAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGCAT
TTAATGCAGGGCTTGTTCAGCCGTGCACTTTAAGAGTAGCCTACCGCGCCAGTTTTGCCAG

Structures

Toxin

• AlphaFold DB: J2XCI1