Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 2618297..2619885 Replicon chromosome
Accession NZ_CP055096
Organism Klebsiella pneumoniae strain SWHIN_108

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag HUZ85_RS12975 Protein ID WP_004184027.1
Coordinates 2618297..2619619 (-) Length 441 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag HUZ85_RS12980 Protein ID WP_004176198.1
Coordinates 2619619..2619885 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HUZ85_RS12960 (2613353) 2613353..2615854 + 2502 WP_032439971.1 fimbria/pilus outer membrane usher protein -
HUZ85_RS12965 (2615842) 2615842..2616846 + 1005 WP_016946380.1 fimbrial protein -
HUZ85_RS12970 (2616988) 2616988..2618280 + 1293 WP_002904794.1 glycoside hydrolase family 10 protein -
HUZ85_RS12975 (2618297) 2618297..2619619 - 1323 WP_004184027.1 type II toxin-antitoxin system HipA family toxin Toxin
HUZ85_RS12980 (2619619) 2619619..2619885 - 267 WP_004176198.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
HUZ85_RS12985 (2620151) 2620151..2620477 - 327 WP_004215084.1 hydroxyisourate hydrolase -
HUZ85_RS12990 (2620474) 2620474..2620974 - 501 WP_032418978.1 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase -
HUZ85_RS12995 (2620952) 2620952..2622331 - 1380 WP_004184021.1 nucleobase:cation symporter-2 family protein -
HUZ85_RS13000 (2622677) 2622677..2623831 + 1155 WP_002904783.1 FAD-dependent urate hydroxylase HpxO -
HUZ85_RS13005 (2623812) 2623812..2624735 - 924 WP_032418980.1 LysR family hpxDE operon transcriptional regulator HpxR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(149-402)

Antitoxin

Cro/C1-type helix-turn-helix domain

(13-65)


Sequences

Toxin        


Download         Length: 441 a.a.        Molecular weight: 49139.47 Da        Isoelectric Point: 7.5367

>T161479 WP_004184027.1 NZ_CP055096:c2619619-2618297 [Klebsiella pneumoniae]
MATLTTWMNNVRVGTLTRQANGAHSFRYEEEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRDRIVRRYQ
ARSKQPFDLLAEVGRDSVGAVTLLPPGEEAHLEGLRWQTLDEAQLTALLTAYQSDIPLGMITSQDDFRISVAGAQEKTAL
LRMGEQWCIPQGATPTTHIIKLPIGEIKQPNATLDLRESVDNEFLCLALARELGLAVPEAEIIATPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGLPSAMKYESDGGPGIAAIMTFLLGSSEALKDRYDFMKFMVFQWLTGATDGHAKNFSIYLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATKGRKTEINAIYPRHFLATAKAVNFPREQMLAILQEFAGHVP
QAIESARRTLPADFSSHVWQAITENMLKLHARLQQGLQAL

Download         Length: 1323 bp

>T161479 NZ_CP071200:4534604-4534915 [Serratia marcescens subsp. marcescens ATCC 13880]
ATGCATATCATTTCCAGGGAACCGTTCAATAACGCAACGAAGCAATATCCCAATGAAGCCACTGCTCTCGAGGCCATTTA
TAAAGCATTGCGACGGGGCGAGTTCCGCACGCCGGACGAGTTAAAAGCGCTTTTTCCTTCGCTCGATCGTATGAAATACA
AAGAGAAATGGTGGGTCATTGACGTCGGCGGCAACCACCTGCGGATCTTGTTCTTTGCCAGCTTCGAGACACAGAAAGTC
TTCATAAAGCATATCGTTAGCCACGCCGAATACGACAAGCTGATGCAGCACTATCGAAGGAGTTCATCATGA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9936.36 Da        Isoelectric Point: 8.5912

>AT161479 WP_004176198.1 NZ_CP055096:c2619885-2619619 [Klebsiella pneumoniae]
MNSPQIYSPVQLANYLKLLRQQNHWTQDALARRIGIKQATLSNFENHPDKTTLTTLFKILQSLGVVMMLNAKAAETAPAP
DNNTDLDW

Download         Length: 267 bp

>AT161479 NZ_CP071200:4534912-4535334 [Serratia marcescens subsp. marcescens ATCC 13880]
ATGATTACAGATGCCATTAAGGCGGCCGATGCGCTACTGCGCGCCGTGCCCTTGTTGCAGGGCAGCCGCGCTCAGCAAGA
CTACCGGGAAGCGCTTGAATTGGTGGAATACCTGCTGGAAAACGACGAACACCATCCGCTGATTGACATGCTGGCAAAAA
AGATCGCCGAATATGAAGACAACAGCGCCGAATTTACCGCATTCAACCAGCGTATCGCCCAGTTACCACAGGGGGTAGCC
GCGCTTCGCGTCCTTATGGAACAGCACCAACTCAGCCAAAGTGATTTTGAACATGAGATCGGTAAAAAGTCGTTGGTTAA
CCAAATCCTGAACGGTAAAAGATCGCTGACCATTCCGCACATTATGGCGCTGGCCAAGCGTTTCAATCTGCCCCCGGCCC
TGTTCCTGCCGGAAGCGGATTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References