Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 777948..778605 Replicon chromosome
Accession NZ_CP055096
Organism Klebsiella pneumoniae strain SWHIN_108

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag HUZ85_RS03855 Protein ID WP_002916310.1
Coordinates 778195..778605 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag HUZ85_RS03850 Protein ID WP_002916312.1
Coordinates 777948..778214 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HUZ85_RS03825 (773104) 773104..774537 - 1434 WP_032418366.1 6-phospho-beta-glucosidase -
HUZ85_RS03830 (774656) 774656..775384 - 729 WP_002916321.1 MurR/RpiR family transcriptional regulator -
HUZ85_RS03835 (775434) 775434..775745 + 312 WP_004144734.1 N(4)-acetylcytidine aminohydrolase -
HUZ85_RS03840 (775909) 775909..776568 + 660 WP_002916317.1 hemolysin III family protein -
HUZ85_RS03845 (776719) 776719..777702 - 984 WP_002916313.1 tRNA-modifying protein YgfZ -
HUZ85_RS03850 (777948) 777948..778214 + 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
HUZ85_RS03855 (778195) 778195..778605 + 411 WP_002916310.1 protein YgfX Toxin
HUZ85_RS03860 (778612) 778612..779133 - 522 WP_004144730.1 flavodoxin FldB -
HUZ85_RS03865 (779234) 779234..780130 + 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
HUZ85_RS03870 (780153) 780153..780866 + 714 WP_004174456.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
HUZ85_RS03875 (780872) 780872..782605 + 1734 WP_004149758.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T161469 WP_002916310.1 NZ_CP055096:778195-778605 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

>T161469 NZ_CP071198:c4454586-4454332 [Serratia marcescens subsp. marcescens ATCC 13880]
ATGAACAAACGACACCAAAAAACGCTGTCAGATGTGTTTGCCCGGCCTGTCAACGGTTCTATAAAGTGGTCTGATATTGA
GGCGCTTTTTACCGCATTAGGGGCGGAGATTCACGAAAGGGAAGGTTCTAGGATCGCGGTGCTGTTGAAAGGTGAAAAAA
GAGTCTTTCACCGGCCACACCCCAGACCTACCACTGACAAGGGGGCGGTTAACTCCATTCGGATCTGGTTGGATAGCTTA
GGAATAAAACCATGA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT161469 WP_002916312.1 NZ_CP055096:777948-778214 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT161469 NZ_CP071198:c4454332-4453991 [Serratia marcescens subsp. marcescens ATCC 13880]
ATGAATAACACACTGAAAATTGACGGCCATACGGCCGTCATCAACTTCGACCCTGAAATTGAAATGTTCCGGGGCGAGTT
TGTCGGGCTGAATGGCGGCGCCGACTTCTACGCCTACAGCGTGGACGAGCTGAAGAAAGAAGGCGCGATCTCACTCGCGG
TCTTTCTCGATGAGTGCCATAAAGACGGCATCGAGCCTTACAAGTCGTACAGCGGCAAAGTAACCACCCGCCTGTCGCCG
GAACGCCATCAGGCGTTAGCCATTGCCGCACAGGCCACCGGGCAGTCGATTAATGAACTGCTGAATGAAGGTGTTGATCT
GGTTATCGAAAAGCATTCCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GSW7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References