Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | hipBA/HipA-HipB |
| Location | 3994305..3995876 | Replicon | chromosome |
| Accession | NZ_CP055095 | ||
| Organism | Proteus mirabilis strain SWHIN_109 | ||
Toxin (Protein)
| Gene name | hipA | Uniprot ID | B4F0T8 |
| Locus tag | HUZ86_RS18320 | Protein ID | WP_012368637.1 |
| Coordinates | 3994305..3995618 (-) | Length | 438 a.a. |
Antitoxin (Protein)
| Gene name | hipB | Uniprot ID | B4F0T9 |
| Locus tag | HUZ86_RS18325 | Protein ID | WP_004249771.1 |
| Coordinates | 3995619..3995876 (-) | Length | 86 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| HUZ86_RS18300 (HUZ86_18270) | 3989474..3990277 | + | 804 | WP_036971860.1 | energy transducer TonB | - |
| HUZ86_RS18305 (HUZ86_18275) | 3990331..3992292 | - | 1962 | WP_036971861.1 | insecticidal delta-endotoxin Cry8Ea1 family protein | - |
| HUZ86_RS18310 (HUZ86_18280) | 3992324..3993253 | - | 930 | WP_004246518.1 | metallophosphoesterase | - |
| HUZ86_RS18315 (HUZ86_18285) | 3993438..3993902 | - | 465 | WP_004249773.1 | DUF1097 domain-containing protein | - |
| HUZ86_RS18320 (HUZ86_18290) | 3994305..3995618 | - | 1314 | WP_012368637.1 | type II toxin-antitoxin system HipA family toxin | Toxin |
| HUZ86_RS18325 (HUZ86_18295) | 3995619..3995876 | - | 258 | WP_004249771.1 | helix-turn-helix domain-containing protein | Antitoxin |
| HUZ86_RS18330 (HUZ86_18300) | 3996025..3997389 | - | 1365 | WP_004246513.1 | tRNA uridine-5-carboxymethylaminomethyl(34) synthesis GTPase MnmE | - |
| HUZ86_RS18335 (HUZ86_18305) | 3997527..3999167 | - | 1641 | WP_004246512.1 | membrane protein insertase YidC | - |
| HUZ86_RS18340 (HUZ86_18310) | 3999170..3999430 | - | 261 | WP_012368639.1 | membrane protein insertion efficiency factor YidD | - |
| HUZ86_RS18345 (HUZ86_18315) | 3999394..3999753 | - | 360 | WP_004246510.1 | ribonuclease P protein component | - |
| HUZ86_RS18350 (HUZ86_18320) | 3999771..3999914 | - | 144 | WP_004246509.1 | 50S ribosomal protein L34 | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 438 a.a. Molecular weight: 49670.78 Da Isoelectric Point: 6.5023
>T161467 WP_012368637.1 NZ_CP055095:c3995618-3994305 [Proteus mirabilis]
MASLDVYMNEYYVGIFTKKSSGAHSFQYTEDWVNQPGSRPISLSMPLQLQEYQGDCVYNFFDNLLPDNTEIRNRIVSRYN
ANSNQPFDLLAAIGADTVGALRLLPSGSTPADIKKIEYQKLNDIELEKILLGYKSNTPLGMLKEYTDFRISIAGAQEKTA
LLLKDNHWCVPHNNTPTTHIIKLPIGVIESHSYTMDLSNSVENEYLCTLIAKEFDLPVPHCSIIKTKNVKALAVERFDRK
YSSDKSWIIRLPQEDFCQILNIPSALKYENEGGPGIIDIMKYLLGSSNADQDRFHFMKAQVLFWLLAATDGHAKNFSVFI
NQEGRFHLTPLYDIMSIYPNFGGRGLNPRDAKLAMGLKASRGKKYAIEQIFPRHFYQTAEAVGFDPSLMSDILRYFYQEM
DDVIQRVKQQLPEDFPSEISNTILDGMKARAVRLANI
MASLDVYMNEYYVGIFTKKSSGAHSFQYTEDWVNQPGSRPISLSMPLQLQEYQGDCVYNFFDNLLPDNTEIRNRIVSRYN
ANSNQPFDLLAAIGADTVGALRLLPSGSTPADIKKIEYQKLNDIELEKILLGYKSNTPLGMLKEYTDFRISIAGAQEKTA
LLLKDNHWCVPHNNTPTTHIIKLPIGVIESHSYTMDLSNSVENEYLCTLIAKEFDLPVPHCSIIKTKNVKALAVERFDRK
YSSDKSWIIRLPQEDFCQILNIPSALKYENEGGPGIIDIMKYLLGSSNADQDRFHFMKAQVLFWLLAATDGHAKNFSVFI
NQEGRFHLTPLYDIMSIYPNFGGRGLNPRDAKLAMGLKASRGKKYAIEQIFPRHFYQTAEAVGFDPSLMSDILRYFYQEM
DDVIQRVKQQLPEDFPSEISNTILDGMKARAVRLANI
Download Length: 1314 bp
>T161467 NZ_CP071198:c3786711-3786322 [Serratia marcescens subsp. marcescens ATCC 13880]
ATGTACATGTTTGATACCAACACCGTCAGCCACTTGTTTCGGCAGCATCCGCAGGTGCTTAACGTCATGGAAAAGCTCCC
GCCTTCTGCCGTATGTATTTCCAGCGTCACGGAGGCGGAACTGCTTTACGGTGTGGCTAAACGGCGGAACAAGGCGTTGC
AAAGCATGGTCGAGGCCTTTCTTGCTGCAGTGACGGTCTATGCATGGGATAGCGAGGCCGCCCGTTGCTACGGTGAAATG
CGGGCAACCATGGAGAGGAAGGGCAAAATCATGGGCGCGATCGATCAACTGATCGCCGCTCACGCGCAGAGCCGTGGCGC
GACGCTGGTGACCAACGATCGCGCATTCGCCATGGTGCCCGGGTTGGCGGTTGAAGACTGGACGCGCTGA
ATGTACATGTTTGATACCAACACCGTCAGCCACTTGTTTCGGCAGCATCCGCAGGTGCTTAACGTCATGGAAAAGCTCCC
GCCTTCTGCCGTATGTATTTCCAGCGTCACGGAGGCGGAACTGCTTTACGGTGTGGCTAAACGGCGGAACAAGGCGTTGC
AAAGCATGGTCGAGGCCTTTCTTGCTGCAGTGACGGTCTATGCATGGGATAGCGAGGCCGCCCGTTGCTACGGTGAAATG
CGGGCAACCATGGAGAGGAAGGGCAAAATCATGGGCGCGATCGATCAACTGATCGCCGCTCACGCGCAGAGCCGTGGCGC
GACGCTGGTGACCAACGATCGCGCATTCGCCATGGTGCCCGGGTTGGCGGTTGAAGACTGGACGCGCTGA
Antitoxin
Download Length: 86 a.a. Molecular weight: 9878.43 Da Isoelectric Point: 10.0139
>AT161467 WP_004249771.1 NZ_CP055095:c3995876-3995619 [Proteus mirabilis]
MIIINAYQLSVHLKDVRLTKKLSQSKVAQKVGIRQDTVSNFELNPNSTKLETFFKLLSALNLEMEIHPKDAKNNLAHKSE
WKEEW
MIIINAYQLSVHLKDVRLTKKLSQSKVAQKVGIRQDTVSNFELNPNSTKLETFFKLLSALNLEMEIHPKDAKNNLAHKSE
WKEEW
Download Length: 258 bp
>AT161467 NZ_CP071198:c3786978-3786715 [Serratia marcescens subsp. marcescens ATCC 13880]
ATGGAAAGAATCGCAAAGCTGTTTAAAAACGGCAGAAATCAGGCGGTGAGGTTACCGGTGGAATTTGAATTTGATACGGA
TCGTGTCTATATCCGTCGCGATCGGGAGGGCAACGTGATTTTATCCAAATATCCGGCAAAGCCGGACAGCTGGGCACCGC
TGCTGAGCATTATCGCCCAAACGCCGGTGCCGCAAGAATTTCTTGGCGCGGAAGATCGTCAGCAAGGGATGGCAGACCGC
GATCCGTTCTCAGAGGAAGAGTAG
ATGGAAAGAATCGCAAAGCTGTTTAAAAACGGCAGAAATCAGGCGGTGAGGTTACCGGTGGAATTTGAATTTGATACGGA
TCGTGTCTATATCCGTCGCGATCGGGAGGGCAACGTGATTTTATCCAAATATCCGGCAAAGCCGGACAGCTGGGCACCGC
TGCTGAGCATTATCGCCCAAACGCCGGTGCCGCAAGAATTTCTTGGCGCGGAAGATCGTCAGCAAGGGATGGCAGACCGC
GATCCGTTCTCAGAGGAAGAGTAG
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|