Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 3791082..3791883 Replicon chromosome
Accession NZ_CP055095
Organism Proteus mirabilis strain SWHIN_109

Toxin (Protein)


Gene name yeeV Uniprot ID A0A0E0XS49
Locus tag HUZ86_RS17360 Protein ID WP_001094437.1
Coordinates 3791082..3791459 (-) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A0E0XTQ1
Locus tag HUZ86_RS17365 Protein ID WP_001390338.1
Coordinates 3791506..3791883 (-) Length 126 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HUZ86_RS17325 (HUZ86_17310) 3786502..3786822 - 321 WP_004246668.1 helix-turn-helix transcriptional regulator -
HUZ86_RS17330 3787594..3787746 + 153 Protein_3359 IS481 family transposase -
HUZ86_RS17335 (HUZ86_17315) 3787871..3788905 - 1035 WP_012368586.1 RhuM family protein -
HUZ86_RS17340 3789045..3789218 - 174 Protein_3361 DUF945 domain-containing protein -
HUZ86_RS17345 (HUZ86_17320) 3789450..3790295 - 846 WP_001274561.1 DUF4942 domain-containing protein -
HUZ86_RS17350 (HUZ86_17325) 3790380..3790577 - 198 WP_000772032.1 DUF957 domain-containing protein -
HUZ86_RS17355 (HUZ86_17330) 3790597..3791085 - 489 WP_000761716.1 DUF5983 family protein -
HUZ86_RS17360 (HUZ86_17335) 3791082..3791459 - 378 WP_001094437.1 TA system toxin CbtA family protein Toxin
HUZ86_RS17365 (HUZ86_17340) 3791506..3791883 - 378 WP_001390338.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
HUZ86_RS17370 (HUZ86_17345) 3792046..3792267 - 222 WP_239637672.1 DUF987 domain-containing protein -
HUZ86_RS17375 (HUZ86_17350) 3792330..3792806 - 477 WP_001535682.1 RadC family protein -
HUZ86_RS17380 (HUZ86_17355) 3792822..3793295 - 474 WP_000855064.1 antirestriction protein -
HUZ86_RS17385 (HUZ86_17360) 3793637..3794455 - 819 WP_001535681.1 DUF932 domain-containing protein -
HUZ86_RS17390 (HUZ86_17365) 3794573..3794768 - 196 Protein_3371 DUF905 family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 13986.90 Da        Isoelectric Point: 7.3223

>T161466 WP_001094437.1 NZ_CP055095:c3791459-3791082 [Proteus mirabilis]
MNTLPDTHVREASGCPSPVTIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SAGAPSQLINSIDILRARRATGLMTRNNYRMVNNITQGKHPEAKR

Download         Length: 378 bp

>T161466 NZ_CP071198:c3109566-3109168 [Serratia marcescens subsp. marcescens ATCC 13880]
ATGTTCAGTCATATGCTGGACACCAACATTGTTATCTATGTCATCAAGCGCCGGCCGCTGGAAGTGCTGGAGGCATTCAA
TCGCTATGCAGGTAAAATGGTCATTTCGTCGATCACTTATGGCGAATTGGTTCACGGGGTGGAGAAAAGCGCTCGTCCAG
CGGTGAACGCCAGAGTCGTTGAGGATTTTGTCTCCCGATTGGACATTCTCGATTACAGCGCCAAAGCGGCATCGCACTAC
GGCAATATCCGGGCTGCGCTGGAACGACAGGGAACGCCTATTGGCGTAAACGATCTACATATTGCCGGGCATGCGCGCAG
CGAAGGATTGATCCTGGTGACCAATAATCGACGCGAATTTGAGCGCGTTGAGGGTTTGCGGCTGGAAAATTGGTTGTAA

Antitoxin


Download         Length: 126 a.a.        Molecular weight: 13745.44 Da        Isoelectric Point: 5.0463

>AT161466 WP_001390338.1 NZ_CP055095:c3791883-3791506 [Proteus mirabilis]
VSDTLSGTTHPDDNDDHPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTITLYAKGLTCEADTLGSCGYAYLAVYPTPAEPAITV

Download         Length: 378 bp

>AT161466 NZ_CP071198:c3109799-3109566 [Serratia marcescens subsp. marcescens ATCC 13880]
ATGACGTTAGGTTCTGTCTTTACTAATAATCGGACACAGGCTGTACGCCTGCCTGCAGAGGCGCGTTTCCCTGATACCGT
TTCTAAAGTGACCGTTCGCGTAGTGGGTAAAGAGCGCATTCTTGCCCCCCTGGAGAATACCTGGGACAGTTTCTTCTGTG
CGGAAAATGAGGTGAGCGATGATTTTCTCAATGAACGTGCCGGACAGCACCAGCGCGAGCGGGAAGCGTTTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0XS49

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0XTQ1

References