Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE-MqsA
Location 3628503..3629202 Replicon chromosome
Accession NZ_CP055095
Organism Proteus mirabilis strain SWHIN_109

Toxin (Protein)


Gene name relE Uniprot ID B4EZ96
Locus tag HUZ86_RS16600 Protein ID WP_004249093.1
Coordinates 3628503..3628889 (+) Length 129 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID B4EZ97
Locus tag HUZ86_RS16605 Protein ID WP_004246828.1
Coordinates 3628882..3629202 (+) Length 107 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HUZ86_RS16585 (HUZ86_16575) 3624522..3625103 - 582 WP_004246833.1 DNA-3-methyladenine glycosylase I -
HUZ86_RS16590 (HUZ86_16580) 3625354..3626259 + 906 WP_004246832.1 glycine--tRNA ligase subunit alpha -
HUZ86_RS16595 (HUZ86_16585) 3626269..3628341 + 2073 WP_004246830.1 glycine--tRNA ligase subunit beta -
HUZ86_RS16600 (HUZ86_16590) 3628503..3628889 + 387 WP_004249093.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
HUZ86_RS16605 (HUZ86_16595) 3628882..3629202 + 321 WP_004246828.1 helix-turn-helix domain-containing protein Antitoxin
HUZ86_RS16610 (HUZ86_16600) 3629251..3629685 - 435 WP_036972158.1 hypothetical protein -
HUZ86_RS16615 (HUZ86_16605) 3629943..3630557 - 615 WP_230458796.1 hypothetical protein -
HUZ86_RS16620 (HUZ86_16610) 3630774..3632060 - 1287 WP_036972156.1 DUF3748 domain-containing protein -
HUZ86_RS16625 (HUZ86_16615) 3632197..3632814 + 618 WP_004246822.1 trimeric intracellular cation channel family protein -
HUZ86_RS16630 (HUZ86_16620) 3633116..3633739 + 624 WP_004246821.1 guanylate kinase -
HUZ86_RS16635 (HUZ86_16625) 3633794..3634069 + 276 WP_004246820.1 DNA-directed RNA polymerase subunit omega -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-2

(1-125)

Antitoxin

Cro/C1-type helix-turn-helix domain

(53-95)


Sequences

Toxin        


Download         Length: 129 a.a.        Molecular weight: 14294.64 Da        Isoelectric Point: 10.0642

>T161465 WP_004249093.1 NZ_CP055095:3628503-3628889 [Proteus mirabilis]
MVIYKTKMFKNSFKKITLTNAELIAIATEVLAGQFEADLGGGVIKKRACIQGKGKSSGIRTIIFYKQGNNLFFADGWKKS
SLSSKKTKEITDDELESYKDLAKDLFNANQNKIDKMIALGLLTEVKYD

Download         Length: 387 bp

>T161465 NZ_CP071198:2039699-2039795 [Serratia marcescens subsp. marcescens ATCC 13880]
AACAAGCCCTGCATTAAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTAGACCGAATATAGGAATC
GTATTCGGTCTTTTTTT

Antitoxin


Download         Length: 107 a.a.        Molecular weight: 12126.21 Da        Isoelectric Point: 10.4411

>AT161465 WP_004246828.1 NZ_CP055095:3628882-3629202 [Proteus mirabilis]
MTDKMKEMLKFAQEMEDAGVTDGSTTKRIAARIKAKELQAKYKHPTPMTGEDIKRIREQNNISQSSLALILNMTKESVSK
WERNEIKPNGAALRLLHLIDKKILFI

Download         Length: 321 bp

>AT161465 NZ_CP071198:c2039795-2039655 [Serratia marcescens subsp. marcescens ATCC 13880]
AAAAAAAGACCGAATACGATTCCTATATTCGGTCTAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGCAT
TTAATGCAGGGCTTGTTCAGCCGTGCACTTTAAGAGTAGCCTACCGCGCCAGTTTTGCCAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB B4EZ96

Antitoxin

Source ID Structure
AlphaFold DB B4EZ97

References