Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | IV | Classification (family/domain) | yeeUV (cbtA-cbeA)/CbtA-CbeA |
Location | 1805263..1806098 | Replicon | chromosome |
Accession | NZ_CP055092 | ||
Organism | Shigella flexneri strain SWHIN_110 |
Toxin (Protein)
Gene name | yeeV | Uniprot ID | A0A1X9TM58 |
Locus tag | HUZ87_RS08630 | Protein ID | WP_000854761.1 |
Coordinates | 1805263..1805640 (-) | Length | 126 a.a. |
Antitoxin (Protein)
Gene name | yeeU | Uniprot ID | S1NM52 |
Locus tag | HUZ87_RS08635 | Protein ID | WP_001295723.1 |
Coordinates | 1805730..1806098 (-) | Length | 123 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
HUZ87_RS08590 (1800652) | 1800652..1800918 | - | 267 | WP_087757644.1 | EutP/PduV family microcompartment system protein | - |
HUZ87_RS08595 (1801288) | 1801288..1801677 | - | 390 | WP_001445118.1 | IS110 family transposase | - |
HUZ87_RS08600 (1801866) | 1801866..1802090 | - | 225 | Protein_1687 | transposase | - |
HUZ87_RS08605 (1802171) | 1802171..1802575 | + | 405 | WP_000839179.1 | transposase | - |
HUZ87_RS08610 (1802572) | 1802572..1802919 | + | 348 | WP_000612626.1 | IS66 family insertion sequence element accessory protein TnpB | - |
HUZ87_RS08615 (1802968) | 1802968..1804507 | + | 1540 | Protein_1690 | IS66-like element ISEc22 family transposase | - |
HUZ87_RS08620 (1804938) | 1804938..1805018 | - | 81 | Protein_1691 | hypothetical protein | - |
HUZ87_RS08625 (1805118) | 1805118..1805266 | - | 149 | Protein_1692 | DUF5983 family protein | - |
HUZ87_RS08630 (1805263) | 1805263..1805640 | - | 378 | WP_000854761.1 | TA system toxin CbtA family protein | Toxin |
HUZ87_RS08635 (1805730) | 1805730..1806098 | - | 369 | WP_001295723.1 | type IV toxin-antitoxin system YeeU family antitoxin | Antitoxin |
HUZ87_RS08640 (1806261) | 1806261..1806482 | - | 222 | WP_000692345.1 | DUF987 domain-containing protein | - |
HUZ87_RS08645 (1806545) | 1806545..1807021 | - | 477 | WP_001186711.1 | RadC family protein | - |
HUZ87_RS08650 (1807036) | 1807036..1807509 | - | 474 | WP_000855059.1 | antirestriction protein | - |
HUZ87_RS08655 (1807851) | 1807851..1808669 | - | 819 | WP_046464190.1 | DUF932 domain-containing protein | - |
HUZ87_RS08660 (1808787) | 1808787..1808982 | - | 196 | Protein_1699 | DUF905 family protein | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
- | inside | Genomic island | - | - | 1802171..1855027 | 52856 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 126 a.a. Molecular weight: 14205.25 Da Isoelectric Point: 7.3249
>T161448 WP_000854761.1 NZ_CP055092:c1805640-1805263 [Shigella flexneri]
MKTLPDTHVREVSCCPSPVTIWQTLLTRLLDQHYSLTLNDTPFVDERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTHSQLINSIDILRARRATGLMTRDNYRTVNNITLGKHPEAKR
MKTLPDTHVREVSCCPSPVTIWQTLLTRLLDQHYSLTLNDTPFVDERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTHSQLINSIDILRARRATGLMTRDNYRTVNNITLGKHPEAKR
Download Length: 378 bp
>T161448 NZ_CP071194:c3109566-3109168 [Serratia marcescens subsp. marcescens ATCC 13880]
ATGTTCAGTCATATGCTGGACACCAACATTGTTATCTATGTCATCAAGCGCCGGCCGCTGGAAGTGCTGGAGGCATTCAA
TCGCTATGCAGGTAAAATGGTCATTTCGTCGATCACTTATGGCGAATTGGTTCACGGGGTGGAGAAAAGCGCTCGTCCAG
CGGTGAACGCCAGAGTCGTTGAGGATTTTGTCTCCCGATTGGACATTCTCGATTACAGCGCCAAAGCGGCATCGCACTAC
GGCAATATCCGGGCTGCGCTGGAACGACAGGGAACGCCTATTGGCGTAAACGATCTACATATTGCCGGGCATGCGCGCAG
CGAAGGATTGATCCTGGTGACCAATAATCGACGCGAATTTGAGCGCGTTGAGGGTTTGCGGCTGGAAAATTGGTTGTAA
ATGTTCAGTCATATGCTGGACACCAACATTGTTATCTATGTCATCAAGCGCCGGCCGCTGGAAGTGCTGGAGGCATTCAA
TCGCTATGCAGGTAAAATGGTCATTTCGTCGATCACTTATGGCGAATTGGTTCACGGGGTGGAGAAAAGCGCTCGTCCAG
CGGTGAACGCCAGAGTCGTTGAGGATTTTGTCTCCCGATTGGACATTCTCGATTACAGCGCCAAAGCGGCATCGCACTAC
GGCAATATCCGGGCTGCGCTGGAACGACAGGGAACGCCTATTGGCGTAAACGATCTACATATTGCCGGGCATGCGCGCAG
CGAAGGATTGATCCTGGTGACCAATAATCGACGCGAATTTGAGCGCGTTGAGGGTTTGCGGCTGGAAAATTGGTTGTAA
Antitoxin
Download Length: 123 a.a. Molecular weight: 13592.40 Da Isoelectric Point: 6.6255
>AT161448 WP_001295723.1 NZ_CP055092:c1806098-1805730 [Shigella flexneri]
VSDTLSGTTHPDDNDDHPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGRFRDADAYPLDQAFPLLMKQLKLMLTSG
ELNPRHQHTVTLYAKGLTCEADTLGSCGYVYLAVYPTPETKK
VSDTLSGTTHPDDNDDHPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGRFRDADAYPLDQAFPLLMKQLKLMLTSG
ELNPRHQHTVTLYAKGLTCEADTLGSCGYVYLAVYPTPETKK
Download Length: 369 bp
>AT161448 NZ_CP071194:c3109799-3109566 [Serratia marcescens subsp. marcescens ATCC 13880]
ATGACGTTAGGTTCTGTCTTTACTAATAATCGGACACAGGCTGTACGCCTGCCTGCAGAGGCGCGTTTCCCTGATACCGT
TTCTAAAGTGACCGTTCGCGTAGTGGGTAAAGAGCGCATTCTTGCCCCCCTGGAGAATACCTGGGACAGTTTCTTCTGTG
CGGAAAATGAGGTGAGCGATGATTTTCTCAATGAACGTGCCGGACAGCACCAGCGCGAGCGGGAAGCGTTTTGA
ATGACGTTAGGTTCTGTCTTTACTAATAATCGGACACAGGCTGTACGCCTGCCTGCAGAGGCGCGTTTCCCTGATACCGT
TTCTAAAGTGACCGTTCGCGTAGTGGGTAAAGAGCGCATTCTTGCCCCCCTGGAGAATACCTGGGACAGTTTCTTCTGTG
CGGAAAATGAGGTGAGCGATGATTTTCTCAATGAACGTGCCGGACAGCACCAGCGCGAGCGGGAAGCGTTTTGA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A1X9TM58 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | S1NM52 |