Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 1805263..1806098 Replicon chromosome
Accession NZ_CP055092
Organism Shigella flexneri strain SWHIN_110

Toxin (Protein)


Gene name yeeV Uniprot ID A0A1X9TM58
Locus tag HUZ87_RS08630 Protein ID WP_000854761.1
Coordinates 1805263..1805640 (-) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID S1NM52
Locus tag HUZ87_RS08635 Protein ID WP_001295723.1
Coordinates 1805730..1806098 (-) Length 123 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HUZ87_RS08590 (1800652) 1800652..1800918 - 267 WP_087757644.1 EutP/PduV family microcompartment system protein -
HUZ87_RS08595 (1801288) 1801288..1801677 - 390 WP_001445118.1 IS110 family transposase -
HUZ87_RS08600 (1801866) 1801866..1802090 - 225 Protein_1687 transposase -
HUZ87_RS08605 (1802171) 1802171..1802575 + 405 WP_000839179.1 transposase -
HUZ87_RS08610 (1802572) 1802572..1802919 + 348 WP_000612626.1 IS66 family insertion sequence element accessory protein TnpB -
HUZ87_RS08615 (1802968) 1802968..1804507 + 1540 Protein_1690 IS66-like element ISEc22 family transposase -
HUZ87_RS08620 (1804938) 1804938..1805018 - 81 Protein_1691 hypothetical protein -
HUZ87_RS08625 (1805118) 1805118..1805266 - 149 Protein_1692 DUF5983 family protein -
HUZ87_RS08630 (1805263) 1805263..1805640 - 378 WP_000854761.1 TA system toxin CbtA family protein Toxin
HUZ87_RS08635 (1805730) 1805730..1806098 - 369 WP_001295723.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
HUZ87_RS08640 (1806261) 1806261..1806482 - 222 WP_000692345.1 DUF987 domain-containing protein -
HUZ87_RS08645 (1806545) 1806545..1807021 - 477 WP_001186711.1 RadC family protein -
HUZ87_RS08650 (1807036) 1807036..1807509 - 474 WP_000855059.1 antirestriction protein -
HUZ87_RS08655 (1807851) 1807851..1808669 - 819 WP_046464190.1 DUF932 domain-containing protein -
HUZ87_RS08660 (1808787) 1808787..1808982 - 196 Protein_1699 DUF905 family protein -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 1802171..1855027 52856


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(1-112)

Antitoxin

(18-117)


Sequences


Toxin        


Download         Length: 126 a.a.        Molecular weight: 14205.25 Da        Isoelectric Point: 7.3249

>T161448 WP_000854761.1 NZ_CP055092:c1805640-1805263 [Shigella flexneri]
MKTLPDTHVREVSCCPSPVTIWQTLLTRLLDQHYSLTLNDTPFVDERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTHSQLINSIDILRARRATGLMTRDNYRTVNNITLGKHPEAKR

Download         Length: 378 bp

>T161448 NZ_CP071194:c3109566-3109168 [Serratia marcescens subsp. marcescens ATCC 13880]
ATGTTCAGTCATATGCTGGACACCAACATTGTTATCTATGTCATCAAGCGCCGGCCGCTGGAAGTGCTGGAGGCATTCAA
TCGCTATGCAGGTAAAATGGTCATTTCGTCGATCACTTATGGCGAATTGGTTCACGGGGTGGAGAAAAGCGCTCGTCCAG
CGGTGAACGCCAGAGTCGTTGAGGATTTTGTCTCCCGATTGGACATTCTCGATTACAGCGCCAAAGCGGCATCGCACTAC
GGCAATATCCGGGCTGCGCTGGAACGACAGGGAACGCCTATTGGCGTAAACGATCTACATATTGCCGGGCATGCGCGCAG
CGAAGGATTGATCCTGGTGACCAATAATCGACGCGAATTTGAGCGCGTTGAGGGTTTGCGGCTGGAAAATTGGTTGTAA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13592.40 Da        Isoelectric Point: 6.6255

>AT161448 WP_001295723.1 NZ_CP055092:c1806098-1805730 [Shigella flexneri]
VSDTLSGTTHPDDNDDHPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGRFRDADAYPLDQAFPLLMKQLKLMLTSG
ELNPRHQHTVTLYAKGLTCEADTLGSCGYVYLAVYPTPETKK

Download         Length: 369 bp

>AT161448 NZ_CP071194:c3109799-3109566 [Serratia marcescens subsp. marcescens ATCC 13880]
ATGACGTTAGGTTCTGTCTTTACTAATAATCGGACACAGGCTGTACGCCTGCCTGCAGAGGCGCGTTTCCCTGATACCGT
TTCTAAAGTGACCGTTCGCGTAGTGGGTAAAGAGCGCATTCTTGCCCCCCTGGAGAATACCTGGGACAGTTTCTTCTGTG
CGGAAAATGAGGTGAGCGATGATTTTCTCAATGAACGTGCCGGACAGCACCAGCGCGAGCGGGAAGCGTTTTGA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB A0A1X9TM58


Antitoxin

Source ID Structure
AlphaFold DB S1NM52

References