Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vagCD/VapC-VagC
Location 41220..41863 Replicon plasmid unnamed1
Accession NZ_CP055090
Organism Citrobacter portucalensis strain SWHIN_111

Toxin (Protein)


Gene name vagD Uniprot ID A0A6C0NE46
Locus tag HUZ88_RS24570 Protein ID WP_008322233.1
Coordinates 41220..41636 (-) Length 139 a.a.

Antitoxin (Protein)


Gene name vagC Uniprot ID Q84A07
Locus tag HUZ88_RS24575 Protein ID WP_001261276.1
Coordinates 41633..41863 (-) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HUZ88_RS24555 (HUZ88_24480) 37290..38309 + 1020 WP_004113181.1 ribose ABC transporter permease -
HUZ88_RS24560 (HUZ88_24485) 38387..39757 + 1371 WP_008322237.1 hypothetical protein -
HUZ88_RS24565 (HUZ88_24490) 39754..40674 + 921 WP_008322235.1 carbohydrate kinase -
HUZ88_RS24570 (HUZ88_24500) 41220..41636 - 417 WP_008322233.1 type II toxin-antitoxin system VapC family toxin Toxin
HUZ88_RS24575 (HUZ88_24505) 41633..41863 - 231 WP_001261276.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
HUZ88_RS24580 (HUZ88_24510) 42116..43138 - 1023 WP_008322227.1 helicase UvrD -
HUZ88_RS24585 (HUZ88_24515) 43224..43928 + 705 WP_001067855.1 IS6-like element IS26 family transposase -
HUZ88_RS24590 (HUZ88_24520) 44331..44687 + 357 WP_000215515.1 cupin domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid aph(3')-Ia / mph(A) / sul1 / qacE / aadA2 / dfrA12 / sul2 / catA2 / tet(A) / aph(6)-Id / aph(3'')-Ib / blaTEM-1B - 1..126719 126719


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(6-129)

Antitoxin

SpoVT-AbrB domain

(7-47)


Sequences

Toxin        


Download         Length: 139 a.a.        Molecular weight: 15054.58 Da        Isoelectric Point: 9.2957

>T161441 WP_008322233.1 NZ_CP055090:c41636-41220 [Citrobacter portucalensis]
MKKTWMLDTNICSFIMREQPAAVLKRLEQAVLRGDRIVVSAVTYAEMRFGATGPKASPRHIQLVDAFCARLDAVLPWDRA
AVDATTDIRVALRLAGTPIGPNDTAIAGHAIAASAVLVTNNVREFARVPGLMLEDWVK

Download         Length: 417 bp

>T161441 NZ_CP071192:c4165718-4165296 [Serratia marcescens subsp. marcescens ATCC 13880]
GTGGCCCAGTGGCGATGTGATATCCGCATTTCCTGGCGCACCCAGCTGTTTTCACTGTTGACCCACGGCGTTCTGATCCT
GCTGATCCTGATTTCGCCCTGGCCGGAGGGCTTTGGCCCGCTCTGGCTGGTGCTGCTGACGCTGGTGGTGTTTCAGTGCA
TTCGCAGCCAGAAGCGCATCGCCGCGGTGCAGGGTGAGCTGCGGCTGCTGGCGGACAGGCGTTTCAGCTGGCACGGCCGC
GAGTGGCGGCTGGCGAAAAAACCGTGGATGCCGGGTTACGGCATGCTGTTGACGCTGCAGCCGATGGAGGGCAAAAAGCG
CCGCCGGCTGTGGCTGGCTTCCGACTGCATGAGCAAAGAGGAGTGGCGCCACCTGCGGCAGCTGTTGCTGCATCCGCCGG
CGGGTAACGGCGAGGAACCCTGA

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8721.74 Da        Isoelectric Point: 4.3533

>AT161441 WP_001261276.1 NZ_CP055090:c41863-41633 [Citrobacter portucalensis]
MRTVSIFKNGNNRAIRLPRDLDFDGVSELEIVREGDSIILRPVRPTWGSFAQLDRADPDFMAEREDVVSDEGRFEP

Download         Length: 231 bp

>AT161441 NZ_CP071192:c4165965-4165699 [Serratia marcescens subsp. marcescens ATCC 13880]
ATGGATATTAACAACAAAGCACGTATTCACTGGGCTTGCCGTCGTGGCATGCGCGAGCTGGACATCTCCATCATGCCGTT
CTTCGAATACGAATACGACAGCCTGAATGACGCGGACAAGGCGCTGTTTATCCGCCTGCTGGAGTGTGACGATCCCGATT
TGTTCAACTGGCTGATGAATCATGGCGCGCCGCAGGATGGCGAGCTGCAGAGAATGGTGACCCTGATCCAAACGCGAAAT
AAAGACCGTGGCCCAGTGGCGATGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A6C0NE46

Antitoxin

Source ID Structure
AlphaFold DB A0A387K023

References