161438

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PumAB/COG3657-dnstrm_HI1420
Location 4680437..4681025 Replicon chromosome
Accession NZ_CP055089
Organism Citrobacter portucalensis strain SWHIN_111

Toxin (Protein)


Gene name PumA Uniprot ID A0A5B0T4T9
Locus tag HUZ88_RS22525 Protein ID WP_032942059.1
Coordinates 4680437..4680754 (+) Length 106 a.a.

Antitoxin (Protein)


Gene name PumB Uniprot ID A0A5B0STC7
Locus tag HUZ88_RS22530 Protein ID WP_032942057.1
Coordinates 4680747..4681025 (+) Length 93 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HUZ88_RS22500 (HUZ88_22460) 4676205..4677029 + 825 WP_048215145.1 PTS system mannose/fructose/sorbose family transporter subunit IID -
HUZ88_RS22505 (HUZ88_22465) 4677098..4678321 + 1224 WP_103015250.1 L-sorbose 1-phosphate reductase -
HUZ88_RS22510 (HUZ88_22470) 4678323..4679135 + 813 WP_032942070.1 shikimate 5-dehydrogenase -
HUZ88_RS22515 4679185..4679367 - 183 WP_008786892.1 hypothetical protein -
HUZ88_RS22520 (HUZ88_22480) 4679622..4680173 + 552 WP_048215148.1 AAA family ATPase -
HUZ88_RS22525 (HUZ88_22485) 4680437..4680754 + 318 WP_032942059.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
HUZ88_RS22530 (HUZ88_22490) 4680747..4681025 + 279 WP_032942057.1 putative addiction module antidote protein Antitoxin
HUZ88_RS22535 (HUZ88_22495) 4681136..4681825 + 690 WP_032942056.1 dipeptidase PepE -
HUZ88_RS22540 (HUZ88_22500) 4681992..4683623 - 1632 WP_048213962.1 Na/Pi cotransporter family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(3-95)

Antitoxin

Uncharacterized protein HI1420

(3-88)


Sequences

Toxin        


Download         Length: 106 a.a.        Molecular weight: 11993.00 Da        Isoelectric Point: 9.6790

>T161438 WP_032942059.1 NZ_CP055089:4680437-4680754 [Citrobacter portucalensis]
IMEILQTMVFRRWEQNLRDRRAKTLIATRLFRLANGLAGDVKPVGEGVSEMRISYGPGYRIYFKQQGCRIIILLCGGDKS
SQANDITLAKMLARTLDSQEIFCHE

Download         Length: 318 bp

>T161438 NZ_CP071192:2040978-2041074 [Serratia marcescens subsp. marcescens ATCC 13880]
AACAAGCCCTGCATTAAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTAGACCGAATATAGGAATC
GTATTCGGTCTTTTTTT

Antitoxin


Download         Length: 93 a.a.        Molecular weight: 9872.45 Da        Isoelectric Point: 5.8233

>AT161438 WP_032942057.1 NZ_CP055089:4680747-4681025 [Citrobacter portucalensis]
MNKLTHYDPATALVDDEEIAVFMADALETGDAAYIAKALGVVARAKGMANIAAETGLSREQLYRSFSEKGNPTLKTTLAV
MKVLGIELTLKK

Download         Length: 279 bp

>AT161438 NZ_CP071192:c2041074-2040934 [Serratia marcescens subsp. marcescens ATCC 13880]
AAAAAAAGACCGAATACGATTCCTATATTCGGTCTAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGCAT
TTAATGCAGGGCTTGTTCAGCCGTGCACTTTAAGAGTAGCCTACCGCGCCAGTTTTGCCAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5B0T4T9

Antitoxin

Source ID Structure
AlphaFold DB A0A5B0STC7

References