161436

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 4170119..4170905 Replicon chromosome
Accession NZ_CP055089
Organism Citrobacter portucalensis strain SWHIN_111

Toxin (Protein)


Gene name yeeV Uniprot ID R8WN26
Locus tag HUZ88_RS20030 Protein ID WP_016154457.1
Coordinates 4170528..4170905 (+) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A242VSK1
Locus tag HUZ88_RS20025 Protein ID WP_009652436.1
Coordinates 4170119..4170478 (+) Length 120 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HUZ88_RS19965 (HUZ88_19935) 4165210..4165476 + 267 WP_009652486.1 hypothetical protein -
HUZ88_RS19970 (HUZ88_19940) 4165489..4165800 + 312 WP_009652410.1 hypothetical protein -
HUZ88_RS19975 (HUZ88_19945) 4165847..4166317 + 471 WP_009652431.1 hypothetical protein -
HUZ88_RS19980 (HUZ88_19950) 4166366..4166878 + 513 WP_009652395.1 DUF4234 domain-containing protein -
HUZ88_RS19985 (HUZ88_19955) 4166961..4167182 + 222 WP_009652443.1 hypothetical protein -
HUZ88_RS19990 (HUZ88_19960) 4167238..4167471 + 234 WP_009652474.1 DUF905 domain-containing protein -
HUZ88_RS19995 (HUZ88_19965) 4167575..4168393 + 819 WP_009652424.1 DUF932 domain-containing protein -
HUZ88_RS20000 (HUZ88_19970) 4168393..4168647 + 255 WP_009652519.1 hypothetical protein -
HUZ88_RS20005 (HUZ88_19975) 4168664..4169137 + 474 WP_009652453.1 antirestriction protein -
HUZ88_RS20010 (HUZ88_19980) 4169148..4169366 + 219 WP_009652503.1 hypothetical protein -
HUZ88_RS20015 (HUZ88_19985) 4169378..4169860 + 483 WP_016154455.1 DNA repair protein RadC -
HUZ88_RS20020 (HUZ88_19990) 4169874..4170095 + 222 WP_009652392.1 DUF987 domain-containing protein -
HUZ88_RS20025 (HUZ88_19995) 4170119..4170478 + 360 WP_009652436.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
HUZ88_RS20030 (HUZ88_20000) 4170528..4170905 + 378 WP_016154457.1 TA system toxin CbtA family protein Toxin
HUZ88_RS20035 (HUZ88_20005) 4170902..4171393 + 492 WP_009652438.1 DUF5983 family protein -
HUZ88_RS20040 (HUZ88_20010) 4171423..4171626 + 204 WP_009652505.1 DUF957 domain-containing protein -
HUZ88_RS20045 (HUZ88_20015) 4171707..4172552 + 846 Protein_3931 DUF4942 domain-containing protein -
HUZ88_RS20050 (HUZ88_20020) 4172988..4174244 + 1257 WP_239605579.1 integrase arm-type DNA-binding domain-containing protein -
HUZ88_RS20055 4174285..4174389 + 105 Protein_3933 recombinase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(15-114)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 14168.19 Da        Isoelectric Point: 9.5224

>T161436 WP_016154457.1 NZ_CP055089:4170528-4170905 [Citrobacter portucalensis]
MQTQPVPPKREVSPRPSPVAIWQRLLSHLLDRHYGLTLNDTPFGKDGVIQEHIDAGISLCDAVNFIVEKYDLVRTDRRGF
NAETQSPLLTSIDILRARKATGLMTRHSYRAVTDITTGKYREVQP

Download         Length: 378 bp

>T161436 NZ_CP071192:c1108033-1107830 [Serratia marcescens subsp. marcescens ATCC 13880]
ATGACTAAAACCGACTATCTGATGCGTTTACGTAAATGCACCACGATTGATACTCTCGAACGTGTTATTGAGAAAAATAA
GTACGAGCTTTCCGATGATGAACTGGAGCTGTTTTACTCAGCGGCCGATCACCGTCTGGCAGAGCTCACCATGAACAAAC
TGTATGACAAAATCCCCACCTCCGTTTGGAAATATGTCAGATAA

Antitoxin


Download         Length: 120 a.a.        Molecular weight: 13286.19 Da        Isoelectric Point: 6.4780

>AT161436 WP_009652436.1 NZ_CP055089:4170119-4170478 [Citrobacter portucalensis]
MSNTIPPVNHDIAAPWWGLKRDITPCFGARLVQEGNRLHYLNDRASITGTFSDADLRHLDQAFPLLLKQLELMLLSGELN
PRHQHCVTLYAKGLICEADSLGSHGYVYLAIYPTPATTE

Download         Length: 360 bp

>AT161436 NZ_CP071192:c1108451-1108083 [Serratia marcescens subsp. marcescens ATCC 13880]
ATGGATGAGTATTCGCCTAAGCGGCACGACATTGCTCAGCTCAAATTCTTGTGCGAAAATTTGTATGATGAAGGTATCGC
TACCCTGGGAGACAGTCATCATGGGTGGGTCAACGATCCGACGTCCTCCGTCAACCTGCAGCTTAATGAGTTGATCGAAC
ATATCGCTTCGTTTGTGATGAGTTATAAAATTAAATACATGGACGAATCTGACCTGTCGGAGTTAGTCGAAGAATATCTC
GACGATACCTATACGCTGTTCAGCAGCTATGGTATCAATGATTCCGACCTGCGCCGCTGGCAAAAAACCAAGGCGAGATT
ATTCAGAATGTTCTCAGGAGAGGACATCTGTACGACAATGAAAACTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB R8WN26

Antitoxin

Source ID Structure
AlphaFold DB A0A242VSK1

References