Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 4021927..4022581 Replicon chromosome
Accession NZ_CP055089
Organism Citrobacter portucalensis strain SWHIN_111

Toxin (Protein)


Gene name cptA Uniprot ID -
Locus tag HUZ88_RS19270 Protein ID WP_048236720.1
Coordinates 4021927..4022334 (-) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID -
Locus tag HUZ88_RS19275 Protein ID WP_003825514.1
Coordinates 4022315..4022581 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HUZ88_RS19250 (HUZ88_19210) 4017818..4019551 - 1734 WP_100271940.1 single-stranded-DNA-specific exonuclease RecJ -
HUZ88_RS19255 (HUZ88_19215) 4019557..4020270 - 714 WP_048225463.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
HUZ88_RS19260 (HUZ88_19220) 4020294..4021190 - 897 WP_003825519.1 site-specific tyrosine recombinase XerD -
HUZ88_RS19265 (HUZ88_19225) 4021304..4021825 + 522 WP_003026933.1 flavodoxin FldB -
HUZ88_RS19270 (HUZ88_19230) 4021927..4022334 - 408 WP_048236720.1 protein YgfX Toxin
HUZ88_RS19275 (HUZ88_19235) 4022315..4022581 - 267 WP_003825514.1 FAD assembly factor SdhE Antitoxin
HUZ88_RS19280 (HUZ88_19240) 4022839..4023822 + 984 WP_239605568.1 tRNA-modifying protein YgfZ -
HUZ88_RS19285 (HUZ88_19245) 4023954..4024616 - 663 WP_006686898.1 hemolysin III family protein -
HUZ88_RS19290 (HUZ88_19250) 4024780..4025091 - 312 WP_008785743.1 N(4)-acetylcytidine aminohydrolase -
HUZ88_RS19295 (HUZ88_19255) 4025144..4025872 + 729 WP_008785744.1 MurR/RpiR family transcriptional regulator -
HUZ88_RS19300 (HUZ88_19260) 4025993..4027426 + 1434 WP_220394611.1 6-phospho-beta-glucosidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 15896.79 Da        Isoelectric Point: 11.3523

>T161435 WP_048236720.1 NZ_CP055089:c4022334-4021927 [Citrobacter portucalensis]
VVQWQSDLRVSWRAQWLSLLIHGLVAVFILLMPWPLSYTPLWLVLLSLVVFDSVRSQRRINACQGEIRLLMDGRLRWQGQ
EWSIVSAPWMVKTGMMLRLRSEAGKRQHLWLAADSMDDAEWRDLRRLMLQKAKQG

Download         Length: 408 bp

>T161435 NZ_CP071192:55329-55604 [Serratia marcescens subsp. marcescens ATCC 13880]
ATGGAATTAAAATGGACGAGTAAGGCGCTATCGGATTTGGCGCGTTTGTTTGAGTTTCTTGCCTTGGCTAACCGCACTGC
GGCAGCGAATTCGGTGAAGGCCTTGGTCGCCGCGCCTAAAGCGTTGCTCGATAATCCTCGCCTGGGTGAAAGACTGGATG
AGTTTTTACCGCAGGAAGTGAGGCGTATTCTGGTCGGCCGTTATGAGATACGTTACCAGGTGCAGCCGGCAACGATTTAT
GTTCTGCGTATTTGGCATACCCGCGAAGAGCGATAG

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10615.14 Da        Isoelectric Point: 5.1700

>AT161435 WP_003825514.1 NZ_CP055089:c4022581-4022315 [Citrobacter portucalensis]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDEEKRIFIRLLECDDPDLFNWLMNHGKPADEQLEQMVRLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT161435 NZ_CP071192:55069-55329 [Serratia marcescens subsp. marcescens ATCC 13880]
ATGAATACGAAAGTCATCACCGCTCATGTGCCGCTGCCTTTGGCTGAAAAGGTGGATGAAATGGCCGCCAAACTTGAACG
TTCACGGGGATGGATAGTGAAGCAAGCCCTCGCCGCCTGGCTTGAGCAAGAGGAAGAACGCCGTCGATTAACGCTGGCGG
CGCTGGCCGATGTCGAACAGCAAAACGTTATCGATCATGAGTCGGTAGAAGCCTGGGCTGCCAGCCTGGACAGTGACGAG
CCGCTGCCGGTACCGCGCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References