Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/UPF0150(antitoxin)
Location 2456688..2457327 Replicon chromosome
Accession NZ_CP055089
Organism Citrobacter portucalensis strain SWHIN_111

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag HUZ88_RS11805 Protein ID WP_123267234.1
Coordinates 2457151..2457327 (-) Length 59 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag HUZ88_RS11800 Protein ID WP_123267772.1
Coordinates 2456688..2457104 (-) Length 139 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HUZ88_RS11780 (HUZ88_11750) 2451735..2452679 - 945 WP_123267231.1 ABC transporter permease -
HUZ88_RS11785 (HUZ88_11755) 2452680..2453696 - 1017 WP_239606499.1 ABC transporter ATP-binding protein -
HUZ88_RS11790 (HUZ88_11760) 2453713..2454858 - 1146 WP_079937306.1 ABC transporter substrate-binding protein -
HUZ88_RS11795 (HUZ88_11765) 2455186..2456595 - 1410 WP_123267233.1 PLP-dependent aminotransferase family protein -
HUZ88_RS11800 (HUZ88_11770) 2456688..2457104 - 417 WP_123267772.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
HUZ88_RS11805 (HUZ88_11775) 2457151..2457327 - 177 WP_123267234.1 type II toxin-antitoxin system HicA family toxin Toxin
HUZ88_RS11810 (HUZ88_11780) 2457591..2458994 + 1404 WP_191228723.1 cytochrome ubiquinol oxidase subunit I -
HUZ88_RS11815 (HUZ88_11785) 2458994..2460004 + 1011 WP_191228722.1 cytochrome d ubiquinol oxidase subunit II -
HUZ88_RS11820 (HUZ88_11790) 2460004..2460129 + 126 WP_003020230.1 DUF2474 domain-containing protein -
HUZ88_RS11825 (HUZ88_11795) 2460319..2460549 + 231 WP_123267237.1 DUF2554 family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-57)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-66)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6784.81 Da        Isoelectric Point: 11.3242

>T161426 WP_123267234.1 NZ_CP055089:c2457327-2457151 [Citrobacter portucalensis]
VKQSEFRRWLESQGVEVTNGSNHLKLRYQGRRSVMPRHPGDEIKEALRKAIQKQLGLK

Download         Length: 177 bp

>T161426 NZ_CP071190:55329-55604 [Serratia marcescens subsp. marcescens ATCC 13880]
ATGGAATTAAAATGGACGAGTAAGGCGCTATCGGATTTGGCGCGTTTGTTTGAGTTTCTTGCCTTGGCTAACCGCACTGC
GGCAGCGAATTCGGTGAAGGCCTTGGTCGCCGCGCCTAAAGCGTTGCTCGATAATCCTCGCCTGGGTGAAAGACTGGATG
AGTTTTTACCGCAGGAAGTGAGGCGTATTCTGGTCGGCCGTTATGAGATACGTTACCAGGTGCAGCCGGCAACGATTTAT
GTTCTGCGTATTTGGCATACCCGCGAAGAGCGATAG

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 15106.28 Da        Isoelectric Point: 4.3529

>AT161426 WP_123267772.1 NZ_CP055089:c2457104-2456688 [Citrobacter portucalensis]
MRYPVNLIPAVEGGFVVSFPDIPEALTQGETRHEALQAAQGALVTAFEFYFDDNEPIPLPSAVGTEADYVEIPLSVASKV
LLLNAFLESNITQQELANRIGRPKQEITRLFDLQHATKIDAVQIAARALGKELSLTML

Download         Length: 417 bp

>AT161426 NZ_CP071190:55069-55329 [Serratia marcescens subsp. marcescens ATCC 13880]
ATGAATACGAAAGTCATCACCGCTCATGTGCCGCTGCCTTTGGCTGAAAAGGTGGATGAAATGGCCGCCAAACTTGAACG
TTCACGGGGATGGATAGTGAAGCAAGCCCTCGCCGCCTGGCTTGAGCAAGAGGAAGAACGCCGTCGATTAACGCTGGCGG
CGCTGGCCGATGTCGAACAGCAAAACGTTATCGATCATGAGTCGGTAGAAGCCTGGGCTGCCAGCCTGGACAGTGACGAG
CCGCTGCCGGTACCGCGCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References