161424

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1236799..1237419 Replicon chromosome
Accession NZ_CP055089
Organism Citrobacter portucalensis strain SWHIN_111

Toxin (Protein)


Gene name Hha Uniprot ID R8WYV2
Locus tag HUZ88_RS05950 Protein ID WP_002892050.1
Coordinates 1236799..1237017 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID R8WZW8
Locus tag HUZ88_RS05955 Protein ID WP_003021733.1
Coordinates 1237045..1237419 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HUZ88_RS05915 (HUZ88_05885) 1232157..1232786 + 630 WP_071445860.1 hypothetical protein -
HUZ88_RS05920 (HUZ88_05890) 1232851..1233204 + 354 WP_048226278.1 DUF1428 family protein -
HUZ88_RS05925 (HUZ88_05895) 1233256..1234809 - 1554 WP_071692491.1 EAL domain-containing protein -
HUZ88_RS05930 (HUZ88_05900) 1234998..1235258 + 261 WP_008783961.1 type B 50S ribosomal protein L31 -
HUZ88_RS05935 (HUZ88_05905) 1235260..1235400 + 141 WP_005125190.1 type B 50S ribosomal protein L36 -
HUZ88_RS05940 (HUZ88_05910) 1235479..1235949 - 471 WP_063941318.1 YlaC family protein -
HUZ88_RS05945 (HUZ88_05915) 1236066..1236617 - 552 WP_003835924.1 maltose O-acetyltransferase -
HUZ88_RS05950 (HUZ88_05920) 1236799..1237017 - 219 WP_002892050.1 HHA domain-containing protein Toxin
HUZ88_RS05955 (HUZ88_05925) 1237045..1237419 - 375 WP_003021733.1 Hha toxicity modulator TomB Antitoxin
HUZ88_RS05965 (HUZ88_05935) 1238685..1241834 - 3150 WP_008783964.1 efflux RND transporter permease AcrB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 1237446..1237823 377


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T161424 WP_002892050.1 NZ_CP055089:c1237017-1236799 [Citrobacter portucalensis]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR

Download         Length: 219 bp

>T161424 NZ_CP071188:c4454595-4454341 [Serratia marcescens subsp. marcescens ATCC 13880]
ATGAACAAACGACACCAAAAAACGCTGTCAGATGTGTTTGCCCGGCCTGTCAACGGTTCTATAAAGTGGTCTGATATTGA
GGCGCTTTTTACCGCATTAGGGGCGGAGATTCACGAAAGGGAAGGTTCTAGGATCGCGGTGCTGTTGAAAGGTGAAAAAA
GAGTCTTTCACCGGCCACACCCCAGACCTACCACTGACAAGGGGGCGGTTAACTCCATTCGGATCTGGTTGGATAGCTTA
GGAATAAAACCATGA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14427.23 Da        Isoelectric Point: 5.5653

>AT161424 WP_003021733.1 NZ_CP055089:c1237419-1237045 [Citrobacter portucalensis]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEQSNHGWVNDPTSATSLQLNELIEHIATFALNYKIKYNEDNKLIAQIDEYL
DDTFMLFSSYGINTQDLQKWRKSGNRLFRCFVNATRANPVSLSC

Download         Length: 375 bp

>AT161424 NZ_CP071188:c4454341-4454000 [Serratia marcescens subsp. marcescens ATCC 13880]
ATGAATAACACACTGAAAATTGACGGCCATACGGCCGTCATCAACTTCGACCCTGAAATTGAAATGTTCCGGGGCGAGTT
TGTCGGGCTGAATGGCGGCGCCGACTTCTACGCCTACAGCGTGGACGAGCTGAAGAAAGAAGGCGCGATCTCACTCGCGG
TCTTTCTCGATGAGTGCCATAAAGACGGCATCGAGCCTTACAAGTCGTACAGCGGCAAAGTAACCACCCGCCTGTCGCCG
GAACGCCATCAGGCGTTAGCCATTGCCGCACAGGCCACCGGGCAGTCGATTAATGAACTGCTGAATGAAGGTGTTGATCT
GGTTATCGAAAAGCATTCCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2P8K6F2

Antitoxin

Source ID Structure
AlphaFold DB R8WZW8

References