Detailed information of TA system TA161423

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-RelB
• Location: 592666..593182
• Replicon: chromosome
• Accession: NZ_CP055089
• Organism: Citrobacter portucalensis strain SWHIN_111

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: HUZ88_RS02955
• Protein ID: WP_239605936.1
• Coordinates: 592898..593182 (+)
• Length: 95 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: A0A6H3AWC7
• Locus tag: HUZ88_RS02950
• Protein ID: WP_003830370.1
• Coordinates: 592666..592908 (+)
• Length: 81 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HUZ88_RS02930 (HUZ88_02910)	587681..588814	+	1134	WP_048227192.1	amidohydrolase/deacetylase family metallohydrolase	-
HUZ88_RS02935 (HUZ88_02915)	588798..589916	+	1119	WP_032942188.1	DgaE family pyridoxal phosphate-dependent ammonia lyase	-
HUZ88_RS02940 (HUZ88_02920)	589913..590653	+	741	WP_048215061.1	KDGP aldolase family protein	-
HUZ88_RS02945 (HUZ88_02925)	590675..592588	+	1914	WP_239605934.1	BglG family transcription antiterminator	-
HUZ88_RS02950 (HUZ88_02930)	592666..592908	+	243	WP_003830370.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
HUZ88_RS02955 (HUZ88_02935)	592898..593182	+	285	WP_239605936.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
HUZ88_RS02960 (HUZ88_02940)	593186..593650	-	465	WP_239605938.1	anaerobic ribonucleoside-triphosphate reductase-activating protein	-
HUZ88_RS02965 (HUZ88_02945)	593810..595948	-	2139	WP_032942192.1	anaerobic ribonucleoside-triphosphate reductase	-
HUZ88_RS02970 (HUZ88_02950)	596357..598009	-	1653	WP_239605940.1	alpha,alpha-phosphotrehalase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (4-83)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (1-65)

Sequences

Toxin

Protein

• Length: 95 a.a.
• Molecular weight: 10908.67 Da
• Isoelectric Point: 10.0482

>T161423 WP_239605936.1 NZ_CP055089:592898-593182 [Citrobacter portucalensis]
MTYELEFDPRALKEWHKLGDTVKTQFKKKLADVLLNSRIDSARLNGLPDCYKIKLKSSGYRLVYQVRDEVVVVFVVAVGK
REHSAVYHDANKRL

Nucleotide

• Length: 285 bp

>T161423 NZ_CP071188:c4164448-4164026 [Serratia marcescens subsp. marcescens ATCC 13880]
GTGGCCCAGTGGCGATGTGATATCCGCATTTCCTGGCGCACCCAGCTGTTTTCACTGTTGACCCACGGCGTTCTGATCCT
GCTGATCCTGATTTCGCCCTGGCCGGAGGGCTTTGGCCCGCTCTGGCTGGTGCTGCTGACGCTGGTGGTGTTTCAGTGCA
TTCGCAGCCAGAAGCGCATCGCCGCGGTGCAGGGTGAGCTGCGGCTGCTGGCGGACAGGCGTTTCAGCTGGCACGGCCGC
GAGTGGCGGCTGGCGAAAAAACCGTGGATGCCGGGTTACGGCATGCTGTTGACGCTGCAGCCGATGGAGGGCAAAAAGCG
CCGCCGGCTGTGGCTGGCTTCCGACTGCATGAGCAAAGAGGAGTGGCGCCACCTGCGGCAGCTGTTGCTGCATCCGCCGG
CGGGTAACGGCGAGGAACCCTGA

Antitoxin

Protein

• Length: 81 a.a.
• Molecular weight: 8945.35 Da
• Isoelectric Point: 5.0651

>AT161423 WP_003830370.1 NZ_CP055089:592666-592908 [Citrobacter portucalensis]
MATLNVRLDDKLKNEAYAVLEKLNITPTEAVRLLFQYVAETGRMPVKTVTLSDSEDALIQTVRERLASPQKGIKVSLDDL

Nucleotide

• Length: 243 bp

>AT161423 NZ_CP071188:c4164695-4164429 [Serratia marcescens subsp. marcescens ATCC 13880]
ATGGATATTAACAACAAAGCACGTATTCACTGGGCTTGCCGTCGTGGCATGCGCGAGCTGGACATCTCCATCATGCCGTT
CTTCGAATACGAATACGACAGCCTGAATGACGCGGACAAGGCGCTGTTTATCCGCCTGCTGGAGTGTGACGATCCCGATT
TGTTCAACTGGCTGATGAATCATGGCGCGCCGCAGGATGGCGAGCTGCAGAGAATGGTGACCCTGATCCAAACGCGAAAT
AAAGACCGTGGCCCAGTGGCGATGTGA

Structures

Antitoxin

• AlphaFold DB: A0A6H3AWC7