Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4900924..4901440 Replicon chromosome
Accession NZ_CP055087
Organism Klebsiella pneumoniae strain SWHIN_114

Toxin (Protein)


Gene name relE Uniprot ID J2XDK6
Locus tag HUZ89_RS24135 Protein ID WP_002886902.1
Coordinates 4900924..4901208 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag HUZ89_RS24140 Protein ID WP_002886901.1
Coordinates 4901198..4901440 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HUZ89_RS24110 (HUZ89_24050) 4896408..4896671 - 264 WP_004152271.1 PTS sugar transporter subunit IIB -
HUZ89_RS24115 (HUZ89_24055) 4896801..4896974 + 174 WP_002886906.1 hypothetical protein -
HUZ89_RS24120 (HUZ89_24060) 4896977..4897720 + 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
HUZ89_RS24125 (HUZ89_24065) 4898077..4900215 + 2139 WP_042943710.1 anaerobic ribonucleoside-triphosphate reductase -
HUZ89_RS24130 (HUZ89_24070) 4900456..4900920 + 465 WP_002886903.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
HUZ89_RS24135 (HUZ89_24075) 4900924..4901208 - 285 WP_002886902.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
HUZ89_RS24140 (HUZ89_24080) 4901198..4901440 - 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
HUZ89_RS24145 (HUZ89_24085) 4901518..4903428 - 1911 WP_004152270.1 PRD domain-containing protein -
HUZ89_RS24150 (HUZ89_24090) 4903451..4904605 - 1155 WP_002886900.1 lactonase family protein -
HUZ89_RS24155 (HUZ89_24095) 4904671..4905411 - 741 WP_002886899.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-82)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11125.95 Da        Isoelectric Point: 10.3787

>T161418 WP_002886902.1 NZ_CP055087:c4901208-4900924 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESARLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

>T161418 NZ_CP071188:c1108033-1107830 [Serratia marcescens subsp. marcescens ATCC 13880]
ATGACTAAAACCGACTATCTGATGCGTTTACGTAAATGCACCACGATTGATACTCTCGAACGTGTTATTGAGAAAAATAA
GTACGAGCTTTCCGATGATGAACTGGAGCTGTTTTACTCAGCGGCCGATCACCGTCTGGCAGAGCTCACCATGAACAAAC
TGTATGACAAAATCCCCACCTCCGTTTGGAAATATGTCAGATAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT161418 WP_002886901.1 NZ_CP055087:c4901440-4901198 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp

>AT161418 NZ_CP071188:c1108451-1108083 [Serratia marcescens subsp. marcescens ATCC 13880]
ATGGATGAGTATTCGCCTAAGCGGCACGACATTGCTCAGCTCAAATTCTTGTGCGAAAATTTGTATGATGAAGGTATCGC
TACCCTGGGAGACAGTCATCATGGGTGGGTCAACGATCCGACGTCCTCCGTCAACCTGCAGCTTAATGAGTTGATCGAAC
ATATCGCTTCGTTTGTGATGAGTTATAAAATTAAATACATGGACGAATCTGACCTGTCGGAGTTAGTCGAAGAATATCTC
GACGATACCTATACGCTGTTCAGCAGCTATGGTATCAATGATTCCGACCTGCGCCGCTGGCAAAAAACCAAGGCGAGATT
ATTCAGAATGTTCTCAGGAGAGGACATCTGTACGACAATGAAAACTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GMH2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References