Detailed information of TA system
Overview
TA module
| Type | IV | Classification (family/domain) | yeeUV (cbtA-cbeA)/CbtA-CbeA |
| Location | 4805638..4806473 | Replicon | chromosome |
| Accession | NZ_CP055087 | ||
| Organism | Klebsiella pneumoniae strain SWHIN_114 | ||
Toxin (Protein)
| Gene name | yeeV | Uniprot ID | A0A5E2RWI0 |
| Locus tag | HUZ89_RS23745 | Protein ID | WP_001559913.1 |
| Coordinates | 4805638..4806015 (-) | Length | 126 a.a. |
Antitoxin (Protein)
| Gene name | yeeU | Uniprot ID | A0A5E3EVB5 |
| Locus tag | HUZ89_RS23750 | Protein ID | WP_032408847.1 |
| Coordinates | 4806105..4806473 (-) | Length | 123 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| HUZ89_RS23705 (HUZ89_23645) | 4801099..4801773 | + | 675 | WP_004152211.1 | hypothetical protein | - |
| HUZ89_RS23710 (HUZ89_23650) | 4801785..4802123 | + | 339 | WP_064449948.1 | hypothetical protein | - |
| HUZ89_RS23715 (HUZ89_23655) | 4802126..4802605 | + | 480 | WP_002887049.1 | type VI secretion system tube protein TssD | - |
| HUZ89_RS23720 (HUZ89_23660) | 4802797..4803120 | - | 324 | Protein_4657 | hypothetical protein | - |
| HUZ89_RS23725 (HUZ89_23665) | 4803139..4804250 | - | 1112 | Protein_4658 | IS3 family transposase | - |
| HUZ89_RS23730 (HUZ89_23670) | 4804702..4804851 | - | 150 | Protein_4659 | restriction endonuclease subunit M | - |
| HUZ89_RS23735 (HUZ89_23675) | 4804936..4805133 | - | 198 | WP_032408848.1 | DUF957 domain-containing protein | - |
| HUZ89_RS23740 (HUZ89_23680) | 4805153..4805641 | - | 489 | WP_001559914.1 | DUF5983 family protein | - |
| HUZ89_RS23745 (HUZ89_23685) | 4805638..4806015 | - | 378 | WP_001559913.1 | TA system toxin CbtA family protein | Toxin |
| HUZ89_RS23750 (HUZ89_23690) | 4806105..4806473 | - | 369 | WP_032408847.1 | type IV toxin-antitoxin system YeeU family antitoxin | Antitoxin |
| HUZ89_RS23755 (HUZ89_23695) | 4806650..4806871 | - | 222 | WP_000692300.1 | DUF987 domain-containing protein | - |
| HUZ89_RS23760 (HUZ89_23700) | 4806940..4807416 | - | 477 | WP_032408846.1 | RadC family protein | - |
| HUZ89_RS23765 (HUZ89_23705) | 4807431..4807916 | - | 486 | WP_088607457.1 | antirestriction protein | - |
| HUZ89_RS23770 (HUZ89_23710) | 4808008..4808826 | - | 819 | WP_001559911.1 | DUF932 domain-containing protein | - |
| HUZ89_RS23775 (HUZ89_23715) | 4808926..4809159 | - | 234 | WP_001119729.1 | DUF905 family protein | - |
| HUZ89_RS23780 (HUZ89_23720) | 4809238..4809693 | - | 456 | WP_000581504.1 | IrmA family protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Genomic island | - | - | 4802126..4824429 | 22303 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 126 a.a. Molecular weight: 14148.10 Da Isoelectric Point: 7.8276
>T161417 WP_001559913.1 NZ_CP055087:c4806015-4805638 [Klebsiella pneumoniae]
MKTLPDTHVREASRCPSPVTIWQTLLSRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQSGF
SACTHSQLINSIDILRARRATGLMTRDNYRTVNNITLGKHPEAKR
MKTLPDTHVREASRCPSPVTIWQTLLSRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQSGF
SACTHSQLINSIDILRARRATGLMTRDNYRTVNNITLGKHPEAKR
Download Length: 378 bp
>T161417 NZ_CP071188:55329-55604 [Serratia marcescens subsp. marcescens ATCC 13880]
ATGGAATTAAAATGGACGAGTAAGGCGCTATCGGATTTGGCGCGTTTGTTTGAGTTTCTTGCCTTGGCTAACCGCACTGC
GGCAGCGAATTCGGTGAAGGCCTTGGTCGCCGCGCCTAAAGCGTTGCTCGATAATCCTCGCCTGGGTGAAAGACTGGATG
AGTTTTTACCGCAGGAAGTGAGGCGTATTCTGGTCGGCCGTTATGAGATACGTTACCAGGTGCAGCCGGCAACGATTTAT
GTTCTGCGTATTTGGCATACCCGCGAAGAGCGATAG
ATGGAATTAAAATGGACGAGTAAGGCGCTATCGGATTTGGCGCGTTTGTTTGAGTTTCTTGCCTTGGCTAACCGCACTGC
GGCAGCGAATTCGGTGAAGGCCTTGGTCGCCGCGCCTAAAGCGTTGCTCGATAATCCTCGCCTGGGTGAAAGACTGGATG
AGTTTTTACCGCAGGAAGTGAGGCGTATTCTGGTCGGCCGTTATGAGATACGTTACCAGGTGCAGCCGGCAACGATTTAT
GTTCTGCGTATTTGGCATACCCGCGAAGAGCGATAG
Antitoxin
Download Length: 123 a.a. Molecular weight: 13682.62 Da Isoelectric Point: 7.8398
>AT161417 WP_032408847.1 NZ_CP055087:c4806473-4806105 [Klebsiella pneumoniae]
VSDKLSGITHPDDNHDRPWWGLPCTVRPCFGARLVQEGNRLHYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVMLYAKGLTCKADTLGSGGYVYLAVYPTPETKK
VSDKLSGITHPDDNHDRPWWGLPCTVRPCFGARLVQEGNRLHYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVMLYAKGLTCKADTLGSGGYVYLAVYPTPETKK
Download Length: 369 bp
>AT161417 NZ_CP071188:55069-55329 [Serratia marcescens subsp. marcescens ATCC 13880]
ATGAATACGAAAGTCATCACCGCTCATGTGCCGCTGCCTTTGGCTGAAAAGGTGGATGAAATGGCCGCCAAACTTGAACG
TTCACGGGGATGGATAGTGAAGCAAGCCCTCGCCGCCTGGCTTGAGCAAGAGGAAGAACGCCGTCGATTAACGCTGGCGG
CGCTGGCCGATGTCGAACAGCAAAACGTTATCGATCATGAGTCGGTAGAAGCCTGGGCTGCCAGCCTGGACAGTGACGAG
CCGCTGCCGGTACCGCGCTGA
ATGAATACGAAAGTCATCACCGCTCATGTGCCGCTGCCTTTGGCTGAAAAGGTGGATGAAATGGCCGCCAAACTTGAACG
TTCACGGGGATGGATAGTGAAGCAAGCCCTCGCCGCCTGGCTTGAGCAAGAGGAAGAACGCCGTCGATTAACGCTGGCGG
CGCTGGCCGATGTCGAACAGCAAAACGTTATCGATCATGAGTCGGTAGAAGCCTGGGCTGCCAGCCTGGACAGTGACGAG
CCGCTGCCGGTACCGCGCTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A5E2RWI0 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A5E3EVB5 |