Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 2766647..2768235 Replicon chromosome
Accession NZ_CP055087
Organism Klebsiella pneumoniae strain SWHIN_114

Toxin (Protein)


Gene name hipA Uniprot ID A0A0H3GN97
Locus tag HUZ89_RS13625 Protein ID WP_004199851.1
Coordinates 2766647..2767969 (-) Length 441 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID A0A0H3GXD8
Locus tag HUZ89_RS13630 Protein ID WP_002904790.1
Coordinates 2767969..2768235 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HUZ89_RS13610 (HUZ89_13575) 2761712..2764213 + 2502 WP_004199853.1 fimbria/pilus outer membrane usher protein -
HUZ89_RS13615 (HUZ89_13580) 2764201..2765205 + 1005 WP_004199852.1 fimbrial protein -
HUZ89_RS13620 (HUZ89_13585) 2765338..2766630 + 1293 WP_002904794.1 glycoside hydrolase family 10 protein -
HUZ89_RS13625 (HUZ89_13590) 2766647..2767969 - 1323 WP_004199851.1 type II toxin-antitoxin system HipA family toxin Toxin
HUZ89_RS13630 (HUZ89_13595) 2767969..2768235 - 267 WP_002904790.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
HUZ89_RS13635 (HUZ89_13600) 2768501..2768827 - 327 WP_002904788.1 hydroxyisourate hydrolase -
HUZ89_RS13640 (HUZ89_13605) 2768824..2769324 - 501 WP_002904787.1 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase -
HUZ89_RS13645 (HUZ89_13610) 2769302..2770681 - 1380 WP_004199850.1 nucleobase:cation symporter-2 family protein -
HUZ89_RS13650 (HUZ89_13615) 2771027..2772181 + 1155 WP_002904783.1 FAD-dependent urate hydroxylase HpxO -
HUZ89_RS13655 (HUZ89_13620) 2772162..2773085 - 924 WP_004199849.1 LysR family hpxDE operon transcriptional regulator HpxR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(149-402)

Antitoxin

Cro/C1-type helix-turn-helix domain

(16-65)


Sequences

Toxin        


Download         Length: 441 a.a.        Molecular weight: 49128.44 Da        Isoelectric Point: 7.2487

>T161414 WP_004199851.1 NZ_CP055087:c2767969-2766647 [Klebsiella pneumoniae]
MATLTTWMNNVRVGTLTRQANGAHSFRYDEEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRDRIVRRYQ
ARSKQPFDLLAEVGRDSVGAVTLLPPGEEAHLEGLRWQTLDEAQLTALLTAYQSDIPLGMITSQDDFRISVAGAQEKTAL
LRMGEQWCIPQGATPTTHIIKLPIGEIKQPNATLDLRESVDNEYLCLALARELGLAVPEAEIITTPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGLPSAMKYESDGGPGIAAIMTFLLGSSEALKDRYDFMKFMVFQWLTGATDGHAKNFSIYLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATKGRKTEINAIYPRHFLATAKAVNFPLEQMLAILQEFAGHVP
QAIESARRTLPADFSSHVWQAITENMLKLHARLQQGLQAL

Download         Length: 1323 bp

>T161414 NZ_CP071180:19307-19648 [Listeria innocua]
ATGGTAAAGCAAGGCGATATTATCAAGATCAATCTAAATCCAAAACAGGGACACGAGCAGCAAGGCTATCGGCCCTATAT
TTGCCTCAGTCATCATCTGGTAAGTGATTATGCAAATATCGCGATCTTTGCCCCAATCAGTAATACACCGCGCACCTATC
CGTTATATGTGCCTTTGACAGGGACAACCACAACCGGAAAAGTATTGCTGGATCAACTAGTTACGATCGATTACAACGCT
CGTAAGCATCAATACGTGGAAACTGTTTCGGATCCATTGCTCACAAAGCTATTAGATACAGTAAAAGTTATTTTTCAAAA
GAACGAGAGATCAACCAACTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9906.27 Da        Isoelectric Point: 8.5912

>AT161414 WP_002904790.1 NZ_CP055087:c2768235-2767969 [Klebsiella pneumoniae]
MNSPQIYSPVQLANYLKLLRQQNHWTQDALARRIGIKQATLSNFENHPDKTTLTTLFKILQSLGVVMTLNAKAAETAPAP
DNNTDLDW

Download         Length: 267 bp

>AT161414 NZ_CP071180:19071-19313 [Listeria innocua]
ATGACCACCGTTAGCGTTAAAAAGTGGGGAAATAGCAAAGCTGTTCGTCTCCCCAATAATCTATTAAATGCCTTAGACAT
CAAAGAGAACGATGATTTGAAAGTGGAAGTGATCAATAATCAGATGATCCTTACCAAAACAGCTATCGATCTCCGAATCG
AGGATCTGTTTGCCAATTACCAGGGCGAACCCTTCCAAACTGAGCTGCAAACATTCGAACCAATCGGAGATGAAAAATGG
TAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GN97

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GXD8

References