Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) shpAB/BrnT-BrnA
Location 3986120..3986696 Replicon chromosome
Accession NZ_CP055075
Organism Shigella flexneri strain SWHIN_116

Toxin (Protein)


Gene name shpA Uniprot ID D3GXZ2
Locus tag HUZ90_RS19515 Protein ID WP_001297643.1
Coordinates 3986409..3986696 (-) Length 96 a.a.

Antitoxin (Protein)


Gene name shpB Uniprot ID A0A829G8Z0
Locus tag HUZ90_RS19510 Protein ID WP_000063156.1
Coordinates 3986120..3986422 (-) Length 101 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HUZ90_RS19495 (3982716) 3982716..3984866 + 2151 WP_001295524.1 pyruvate/proton symporter BtsT -
HUZ90_RS19500 (3984916) 3984916..3985119 + 204 WP_000467859.1 YbdD/YjiX family protein -
HUZ90_RS19505 (3985130) 3985130..3986086 + 957 WP_001297640.1 GTPase -
HUZ90_RS19510 (3986120) 3986120..3986422 - 303 WP_000063156.1 BrnA antitoxin family protein Antitoxin
HUZ90_RS19515 (3986409) 3986409..3986696 - 288 WP_001297643.1 BrnT family toxin Toxin
HUZ90_RS19520 (3986895) 3986895..3987592 - 698 Protein_3827 IS1 family transposase -
HUZ90_RS19525 (3987649) 3987649..3987744 + 96 Protein_3828 dienelactone hydrolase family protein -
HUZ90_RS19530 (3987890) 3987890..3989122 + 1233 WP_001339512.1 multidrug efflux MFS transporter MdtM -
HUZ90_RS19535 (3989163) 3989163..3990443 + 1281 WP_001037380.1 DUF445 domain-containing protein -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.



Sequences


Toxin        


Download         Length: 96 a.a.        Molecular weight: 11295.77 Da        Isoelectric Point: 6.8821

>T161389 WP_001297643.1 NZ_CP055075:c3986696-3986409 [Shigella flexneri]
MPMEFEWDENKAKSNRVKHGIRFEDAVLLFDDPQHLSQQERIENGEYRWQTIGLVYGIVVILVAHTIRFESGNEIIRIIS
ARKADRKERNRYEHG

Download         Length: 288 bp

>T161389 NZ_CP071150:3693021-3693338 [Klebsiella pneumoniae]
ATGTTCAGATTGGTTGTGCATGTGGACGTTAAAAAGGAATTGCAGGCGCTTCCGCCCATTGTCCAGGCGAAGATGATCCG
GCAATTAGACAAGTTACGCCAAAATCCCACCGCGCTGAGAGAACCTGACAGTAAACCGCTGGGGCAGGGGCTATTTGAAA
TTCGTGCGTTAGGTTCGGTACAGGGGCGAGGGATCTACGTTTTTCAGCAAGGCAAGACGCTCTTTCTGCTACGGGTTTTT
GTCAAGAAAACGCAAAAAACTCCGTCATCGGAAATTCGCCTGGCGCTGAAGCGATTAGAGGAGATGCGCAATGAGTAA

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11521.99 Da        Isoelectric Point: 9.4646

>AT161389 WP_000063156.1 NZ_CP055075:c3986422-3986120 [Shigella flexneri]
MSMVKHKRGTSSTLDVQHEAELKALANKSDEDIDYSDIPPSSDEQWSNAERGKFYRPLKTQASVRIDADVMEWLKRPGKG
YQTRLNAILREAMLRDQNKK

Download         Length: 303 bp

>AT161389 NZ_CP071150:3693331-3693618 [Klebsiella pneumoniae]
ATGAGTAAAAAGATCATTGACTGGGATACGTTAAAAACAGAACTGCTTGGCCAGCCTGAGGTTCAGGCTGCATTCGATGC
GCAAGAACGTCAACAGCGATTACGTACTATGCTGGCGCAATGGCGCGAGCAGGCGGGGCTAACCCGAGCCCAGGTGGCGC
AGAGGATGGGGGTGAGTGCGCCGACGGTCTCCAGAATGGAAGCCAATATCACCCGCGCCAGTCTGGATACCTTAACGCGA
TACGCGTTAGCCTGCGGTATAAAGCACCCGCAAGTTTTACTTTACTAA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB A0A829GEV9


Antitoxin

Source ID Structure
AlphaFold DB A0A829G8Z0

References