Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 773848..774683 Replicon chromosome
Accession NZ_CP055075
Organism Shigella flexneri strain SWHIN_116

Toxin (Protein)


Gene name yeeV Uniprot ID A0A1C0Y405
Locus tag HUZ90_RS03785 Protein ID WP_001774607.1
Coordinates 773848..774225 (-) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID -
Locus tag HUZ90_RS03790 Protein ID WP_239635703.1
Coordinates 774315..774683 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HUZ90_RS03745 (769361) 769361..769441 + 81 Protein_736 general secretion pathway protein E -
HUZ90_RS03750 (769441) 769441..769590 + 150 Protein_737 type II secretion system protein GspF -
HUZ90_RS03755 (769589) 769589..770233 + 645 Protein_738 type II secretion system minor pseudopilin GspK -
HUZ90_RS03760 (770230) 770230..771408 + 1179 WP_000094976.1 type II secretion system protein GspL -
HUZ90_RS03765 (771410) 771410..771946 + 537 WP_000942792.1 GspM family type II secretion system protein YghD -
HUZ90_RS03770 (772227) 772227..773069 - 843 WP_040235333.1 DUF4942 domain-containing protein -
HUZ90_RS03775 (773154) 773154..773351 - 198 WP_032152719.1 DUF957 domain-containing protein -
HUZ90_RS03780 (773363) 773363..773851 - 489 WP_001774608.1 DUF5983 family protein -
HUZ90_RS03785 (773848) 773848..774225 - 378 WP_001774607.1 TA system toxin CbtA family protein Toxin
HUZ90_RS03790 (774315) 774315..774683 - 369 WP_239635703.1 type IV toxin-antitoxin system cytoskeleton bundling-enhancing antitoxin CbeA Antitoxin
HUZ90_RS03795 (774846) 774846..775067 - 222 WP_000692303.1 DUF987 domain-containing protein -
HUZ90_RS03800 (775130) 775130..775606 - 477 WP_001186710.1 RadC family protein -
HUZ90_RS03805 (775618) 775618..776097 - 480 WP_000860065.1 antirestriction protein -
HUZ90_RS03810 (776179) 776179..776997 - 819 WP_001234631.1 DUF932 domain-containing protein -
HUZ90_RS03815 (777096) 777096..777329 - 234 WP_001278287.1 DUF905 family protein -
HUZ90_RS03820 (777335) 777335..778012 - 678 WP_001097306.1 hypothetical protein -
HUZ90_RS03825 (778160) 778160..778840 - 681 WP_001593697.1 WYL domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 14218.20 Da        Isoelectric Point: 7.8045

>T161372 WP_001774607.1 NZ_CP055075:c774225-773848 [Shigella flexneri]
MKTLPDTHVREASRCPPPVTIWQTLLSRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDTVNFLVEKYALIRTDQPGF
SACTRSQLINSIDILRARRATGLMTRDNYRTVNNITQGKHPEAKQ

Download         Length: 378 bp

>T161372 NZ_CP071142:1668981-1669823 [Streptococcus equi subsp. equi]
ATGAATAAAGCTAAATTAACGGCTCTTTGCCATAAAGTTAGTAAAGAAGTCGGTCTTTCGTTTAATGCTGTTATGTTATA
TTATTTTTTAGAAAGTATTTTAAAAAAATTAGCAGGAAGCAAATATAGTGAACGATTTATTTTTAAGGGCGGCTTTTTGT
TATCAAGTGTAGTTGGAATTGATTCAAGAAGTACTGTAGATATAGACTTTCTTTTGAGAAATATGCAACTATCAGAAGAA
AATATTGTTCAAATGCTGAACGAAACTTTAAAACCGGAAGAATTCGACGATATTTTTTATGAATTGCAAAACATTGTGCC
AATCAAAGAAGAAGATCAATATGGAGGATTTCGTGCAAATATCTTATGTAAAATGGAAAATATAAGACAGATTGTACCAC
TTGACATTGCAACAGGAGATGTTATTACACCTCATCCGATAGATTATAAGTATGTGAGTTCTTTTGGAGAAGAAGAAATA
ATAATCAAGGCTTATCCGATAGAAACTATGCTTGCAGAAAAAATACAAACTATTTATGCAAGAGGATTTTTAAATAGTAG
AAGTAAGGATTATTACGATCTTTATATTATTTATAAATTAAAGGATAAAGATGTAAATGTAGAGATATTAAGAGAGGCTT
GCAGAAAAACTTTTAGTTATAGAAAAACAGAATTTGACATAGGTAAAATCATAGACTTACTGGAAAAATTGAAAATAAAT
GAAGCCTTTTTGAAAAGATGGCAAGCTTATTCAAGAAAAAATCTGTATGCGAAAGATATAACTTTTGAAGAAGTATTGGA
CAACGGAATAAAAATGGTGGAAAAAATAAAGAATGAAAATTAG

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13477.30 Da        Isoelectric Point: 6.3161

>AT161372 WP_239635703.1 NZ_CP055075:c774683-774315 [Shigella flexneri]
VSDALSGTMLPDDNHDRPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGLFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCKADTLGSGGYVYLAVYPTPETKN

Download         Length: 369 bp

>AT161372 NZ_CP071142:1668395-1668988 [Streptococcus equi subsp. equi]
ATGAATTATGAAAATAAAATTGAAAAATATTTGAAGCAATCAGGTGGAATTATTACAACAGCATACTGTAAGGAAAATAA
TATACCGACGATATATCTCAGTCGACTATTGAAAGATGGGAGATTGTCAAAAGTAAGAAAAGGAATTTATATAACGAAAG
ATGGGGATTACGATGAGTATTATTTCTTTCAACATCAGTATAAAAAGGCGATATTTTCTTATGAAACAGCACTTTACCTG
CTTGGACAAACAGATAAAATTCCTTGGAGTATCGATGTAACCGTTTATAACGGATATAAATTTAATGAAAAACCGAACGG
TTTCAATGTTCATTATGTAAAAAAATCAATTTATGACTTAGGGGTAACCCAAAAACCTACAATGTTTGGAAATAAAGTTA
AGGTATATTCATATGAGAGGACACTCTGTGATTTTATTGCTCATAAAGAAGAAATGGATATAGAGGTTTATGTAAAACTT
ATTCAATCATATTCCTCTTATAAAGAAAGAGATATCCATTCCCTCTATGACATTGCAATGAAAATGGGAATTGAAAATAA
AGTAAGAGAGGTTATGGAGGTGGCTTATGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1C0Y405

Antitoxin

Source ID Structure

References