Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | relBE/ParE-DnaT |
| Location | 11393..11915 | Replicon | plasmid unnamed3 |
| Accession | NZ_CP055073 | ||
| Organism | Shigella flexneri strain SWHIN_97 | ||
Toxin (Protein)
| Gene name | relE | Uniprot ID | G3CAN5 |
| Locus tag | HUZ91_RS24495 | Protein ID | WP_000220560.1 |
| Coordinates | 11634..11915 (+) | Length | 94 a.a. |
Antitoxin (Protein)
| Gene name | relB | Uniprot ID | G3CAG1 |
| Locus tag | HUZ91_RS24490 | Protein ID | WP_000121743.1 |
| Coordinates | 11393..11644 (+) | Length | 84 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| HUZ91_RS24460 (HUZ91_24250) | 6756..6986 | + | 231 | WP_000051064.1 | plasmid partition protein ParG | - |
| HUZ91_RS24465 (HUZ91_24255) | 7002..7295 | + | 294 | WP_015060510.1 | hypothetical protein | - |
| HUZ91_RS24470 (HUZ91_24260) | 7297..8265 | + | 969 | WP_077249520.1 | IS5-like element IS903B family transposase | - |
| HUZ91_RS24475 (HUZ91_24265) | 8325..8678 | - | 354 | WP_000876434.1 | DNA distortion polypeptide 3 | - |
| HUZ91_RS24480 (HUZ91_24275) | 8815..9261 | - | 447 | WP_001074386.1 | hypothetical protein | - |
| HUZ91_RS24485 (HUZ91_24280) | 9301..10137 | - | 837 | WP_001050931.1 | RepB family plasmid replication initiator protein | - |
| HUZ91_RS24490 (HUZ91_24285) | 11393..11644 | + | 252 | WP_000121743.1 | plasmid stabilization protein | Antitoxin |
| HUZ91_RS24495 (HUZ91_24290) | 11634..11915 | + | 282 | WP_000220560.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| HUZ91_RS24500 (HUZ91_24295) | 12061..12384 | + | 324 | WP_001181903.1 | hypothetical protein | - |
| HUZ91_RS24505 (HUZ91_24300) | 12429..12674 | + | 246 | WP_000356546.1 | hypothetical protein | - |
| HUZ91_RS24510 (HUZ91_24305) | 12664..12879 | + | 216 | WP_001180116.1 | hypothetical protein | - |
| HUZ91_RS24515 (HUZ91_24310) | 12972..13301 | + | 330 | WP_000866648.1 | hypothetical protein | - |
| HUZ91_RS24520 (HUZ91_24315) | 13588..13737 | + | 150 | WP_000003880.1 | hypothetical protein | - |
| HUZ91_RS24525 (HUZ91_24320) | 13750..14022 | + | 273 | WP_000160399.1 | hypothetical protein | - |
| HUZ91_RS24530 (HUZ91_24325) | 14349..14894 | + | 546 | WP_038976855.1 | DNA distortion polypeptide 1 | - |
| HUZ91_RS24535 (HUZ91_24330) | 14897..16054 | + | 1158 | WP_000538023.1 | DNA distortion polypeptide 2 | - |
| HUZ91_RS24540 (HUZ91_24335) | 16415..16906 | + | 492 | WP_038976853.1 | transcription termination/antitermination NusG family protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Non-Mobilizable plasmid | qnrS1 / blaTEM-176 / aph(3')-Ia / dfrA14 / floR / tet(A) | - | 1..46569 | 46569 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 94 a.a. Molecular weight: 11005.83 Da Isoelectric Point: 10.5938
>T161369 WP_000220560.1 NZ_CP055073:11634-11915 [Shigella flexneri]
MTYELAFDRRALKEWQKLGHTIREQFKKKLAERLENPRVPAARLHGHADRYKIKLRASGYRLVYQVIDEKVVLLVIAVGR
RESSEVYQIADLR
MTYELAFDRRALKEWQKLGHTIREQFKKKLAERLENPRVPAARLHGHADRYKIKLRASGYRLVYQVIDEKVVLLVIAVGR
RESSEVYQIADLR
Download Length: 282 bp
>T161369 NZ_CP071139:3795830-3796087 [Streptomyces nojiriensis]
GTGAGGAGCGTCCACTTCGACCCGGCCGCCTGGGAGGACTTCCTGTTCTGGCTCTCGTCGGACCGGAAGATGGCCCGACG
GATCACCCGCCTGATCGGCGAGATCCAGCGGGACCCCTTCACCGGCATCGGCAAGCCCGAGCCGCTGAAGGGCGAGTTGA
CGGGCTACTGGTCCCGCCGCATCGACGACGAGCACCGCCTCGTGTACCGGGCCGACGACAAGGAAGTGAAGGTCCTCAAG
GCGCGCTACCACTACTGA
GTGAGGAGCGTCCACTTCGACCCGGCCGCCTGGGAGGACTTCCTGTTCTGGCTCTCGTCGGACCGGAAGATGGCCCGACG
GATCACCCGCCTGATCGGCGAGATCCAGCGGGACCCCTTCACCGGCATCGGCAAGCCCGAGCCGCTGAAGGGCGAGTTGA
CGGGCTACTGGTCCCGCCGCATCGACGACGAGCACCGCCTCGTGTACCGGGCCGACGACAAGGAAGTGAAGGTCCTCAAG
GCGCGCTACCACTACTGA
Antitoxin
Download Length: 84 a.a. Molecular weight: 9194.43 Da Isoelectric Point: 4.1683
>AT161369 WP_000121743.1 NZ_CP055073:11393-11644 [Shigella flexneri]
MSYQILTTTAASITDLKKNPMGTVAEGEGDAVAILNRNEPAFYCVPPKLYAYYRELAEDAELNAVADERMKNPEIVKVNL
DDL
MSYQILTTTAASITDLKKNPMGTVAEGEGDAVAILNRNEPAFYCVPPKLYAYYRELAEDAELNAVADERMKNPEIVKVNL
DDL
Download Length: 252 bp
>AT161369 NZ_CP071139:3795558-3795833 [Streptomyces nojiriensis]
ATGTCCATAAGCGCCAGCGAAGCCAGGGCGACCCTGTTCCCGCTGATCGAGCGCGTGAACACCGACCACGCCCCGGTGCG
CATCACCTCCAAGAGCGGTGACGCGGTCCTCATGTCCGCCGACGACTACGACTCCTGGCAGGAGACCGTGTACCTCCTGC
GCTCCCCCGCCAACGCCCAGCGATTGATGGAGGCCGTCGCGCGTGACCGCGAGGGTGCTTCCACCGTGGTCAGGACGCTG
GACGAGCTGAGGGAGTTGGCCGGGGGCGAGGAGTGA
ATGTCCATAAGCGCCAGCGAAGCCAGGGCGACCCTGTTCCCGCTGATCGAGCGCGTGAACACCGACCACGCCCCGGTGCG
CATCACCTCCAAGAGCGGTGACGCGGTCCTCATGTCCGCCGACGACTACGACTCCTGGCAGGAGACCGTGTACCTCCTGC
GCTCCCCCGCCAACGCCCAGCGATTGATGGAGGCCGTCGCGCGTGACCGCGAGGGTGCTTCCACCGTGGTCAGGACGCTG
GACGAGCTGAGGGAGTTGGCCGGGGGCGAGGAGTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | G3CAN5 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A3S5I301 |