Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-YafN
Location 1824..2359 Replicon plasmid unnamed1
Accession NZ_CP055071
Organism Shigella flexneri strain SWHIN_97

Toxin (Protein)


Gene name relE Uniprot ID Q3YTD6
Locus tag HUZ91_RS23280 Protein ID WP_000222766.1
Coordinates 2072..2359 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID V0VIP2
Locus tag HUZ91_RS23275 Protein ID WP_001132900.1
Coordinates 1824..2075 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HUZ91_RS23270 (1) 1..858 + 858 WP_039002220.1 incFII family plasmid replication initiator RepA -
HUZ91_RS23275 (1824) 1824..2075 + 252 WP_001132900.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
HUZ91_RS23280 (2072) 2072..2359 + 288 WP_000222766.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
HUZ91_RS23285 (2434) 2434..2622 - 189 Protein_3 IS3 family transposase -
HUZ91_RS23290 (2656) 2656..3156 - 501 Protein_4 Tn3 family transposase -
HUZ91_RS23295 (3190) 3190..4488 - 1299 Protein_5 Tn3-like element Tn3 family transposase -
HUZ91_RS23300 (4556) 4556..5260 + 705 WP_001067855.1 IS6-like element IS26 family transposase -
HUZ91_RS23305 (5454) 5454..5840 + 387 WP_063102497.1 bleomycin binding protein -
HUZ91_RS23310 (6160) 6160..6552 - 393 WP_000084745.1 pyridoxamine 5'-phosphate oxidase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid oqxA / oqxB / qnrS1 / sul3 - 1..144275 144275


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-83)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11147.23 Da        Isoelectric Point: 10.5832

>T161362 WP_000222766.1 NZ_CP055071:2072-2359 [Shigella flexneri]
MTYTVKFRDDALKEWLKLDKTIQQQFVKKLKKCSENPHIPSAKLRGLKDCYKIKLRASGFRLVYQVIDDMLIIAVVAVGK
RERSNVYNLASERMR

Download         Length: 288 bp

>T161362 NZ_CP071137:c2405940-2404645 [Ferrovum myxofaciens]
ATGGCGCATGAGCTGGAAGTCTGGTTATTCGCCGACCGTGCAGGCACCCTGACGCTCGTCGCGGGACGGCTGGCTTTTTG
CTACGACCCTAATTGGTTGTCTCGGCCTCAAGCTGTAGCATTATCCGTCTCGTTGCCTTTGCAAGCGGAGCCGTTCGACG
ATCACAAAACTCGCCCATTCTTTGCCGGCCTCCTGCCAGAGGGACAGATGCGTCGTCTGATTGCGCAGCAGTTCCAGGTA
TCAAACCAGAACGACTTTGCGCTGCTGGACCACATCGGCGGAGAATGTGCCGGGGCGGTGACATTCTTGGAGCCAGGGCA
GGCCTTACCTGCATCAACCCAGTGCGAGGATATTCAATGGCTGAGCAATGAAGAAGTCATTGCCATCCTGGATGAATTGC
CTCATCGCCCCATGCTGGCAGGCAAAGATGGACTGCGGCTTTCCCTGGCTGGCGCCCAAGACAAACTACCGGTAGTTTTT
GATGGTGCCCGCATTGGCCTGCCTCACAATGGCACGCCCAGTTCCCACATTTTGAAGCCACCCATCCATGCCGTTGAAGA
CAGTGTGGCCAATGAGGGTTTCTGCTTGACGCTGGCCAATACCTTGCAACTCAAACCCGCCAAGGCCAAGGTTCACTCCA
TTGGAACTCGATCATTCTTGCTGGTTGAGCGCTACGACCGGAGTCTGGATAAAGTAGGGCACCGACGGCGCATTCATCAA
GAGGATTTTTGCCAGGCATTGGGTGTCGTGCCTGAAATTAAATATCAGAACGAAGGTGGACCGGATCTGGCGCAATGCTT
CGATCTGGTCCGCCGTGTCTCCCGCCCCAGCGCACCACAGGTGCTGCGCTTGCTCGATTATGTGATATTCAACGCACTGA
CCGGCAATCATGACGCGCACGCCAAGAATTTCTCTCTGCTGTATTTAATCGAGGGGCCTGTCCTGGCCCCGTTCTACGAC
ACGCTCTCCACTGCGGTGTATCCGATGCTGACGCCCAAGATGGCGATGAAAATCGGCAGCAAATACAAGTTCAGCGAGAT
CCAGGCACGGCACTGGGATCAGCTTGCTGAAGGCGCTGGACTGGCCAAGGCACTGACCAAAAAACGCATTCTGGAATTGG
CAAAGTCGCTGCCGCCAACCGCACGCAAGATCCAATCCGACCCTGGGCATGGCTTTTCTGGAAATGCCGTGGTTGAGCGA
ATCATTGCTTTGATTGAACAACGCTGTGCCTTGACGATTCGTCGACTCACCGATCCTGCTGTTGACAACGAAGATGACAC
CGAGCCATCCTCTTAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9211.41 Da        Isoelectric Point: 4.0780

>AT161362 WP_001132900.1 NZ_CP055071:1824-2075 [Shigella flexneri]
MPNIILSDTSASVSELKKNPMATVSAGDGYPVAILNRNQPAFYCVPAELYERMLDALDDQELVKLVTERSNQPLHDVDLD
SYL

Download         Length: 252 bp

>AT161362 NZ_CP071137:c2406190-2405930 [Ferrovum myxofaciens]
ATGACAACCATTCGATCACCTCAACAACTCGGCGATGCACTTCGTGCCGCCCGCAAGCAACTTGCTTTGACGCAGCCTCA
ACTGGCTCTGGCGGCGGGGGTTGGTGTGCGCTTCATTGTCGATCTTGAGGCAGGAAAACCTACCCTGCGACTCGAAAATG
TTCTGCGGGTCATTGATGCGTTGGGCGGAGAAATCATAATTAGCGGATTGCCCTCCGGAGTTGCCGAAGATCAACGCTCG
GGCAACGACTATGGCGCATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829CDZ2

Antitoxin

Source ID Structure
AlphaFold DB V0VIP2

References