Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 1794818..1795653 Replicon chromosome
Accession NZ_CP055070
Organism Shigella flexneri strain SWHIN_97

Toxin (Protein)


Gene name yeeV Uniprot ID A0A7I6H0K3
Locus tag HUZ91_RS08690 Protein ID WP_000854760.1
Coordinates 1794818..1795195 (-) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID S1NM52
Locus tag HUZ91_RS08695 Protein ID WP_001295723.1
Coordinates 1795285..1795653 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HUZ91_RS08655 (1790338) 1790338..1790811 + 474 WP_001105407.1 DNA gyrase inhibitor SbmC -
HUZ91_RS08660 (1791009) 1791009..1792067 + 1059 WP_001200895.1 FUSC family protein -
HUZ91_RS08665 (1792239) 1792239..1792568 + 330 WP_000450409.1 DUF496 family protein -
HUZ91_RS08670 (1792669) 1792669..1793034 - 366 WP_001280454.1 EutP/PduV family microcompartment system protein -
HUZ91_RS08675 (1793305) 1793305..1793676 - 372 WP_001295631.1 IS110 family transposase -
HUZ91_RS08680 (1794492) 1794492..1794572 - 81 Protein_1704 hypothetical protein -
HUZ91_RS08685 (1794618) 1794618..1794821 - 204 WP_000761705.1 DUF5983 family protein -
HUZ91_RS08690 (1794818) 1794818..1795195 - 378 WP_000854760.1 TA system toxin CbtA family protein Toxin
HUZ91_RS08695 (1795285) 1795285..1795653 - 369 WP_001295723.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
HUZ91_RS08700 (1795816) 1795816..1796037 - 222 WP_000692345.1 DUF987 domain-containing protein -
HUZ91_RS08705 (1796106) 1796106..1796582 - 477 WP_001424026.1 RadC family protein -
HUZ91_RS08710 (1796598) 1796598..1797071 - 474 WP_001387789.1 antirestriction protein -
HUZ91_RS08715 (1797413) 1797413..1798231 - 819 WP_239606171.1 DUF932 domain-containing protein -
HUZ91_RS08720 (1798349) 1798349..1798544 - 196 Protein_1712 DUF905 family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 14165.19 Da        Isoelectric Point: 7.3249

>T161344 WP_000854760.1 NZ_CP055070:c1795195-1794818 [Shigella flexneri]
MKTLPDTHVREVSCCPSPVTIWQTLLTRLLDQHYGLTLNDTPFVDERVIEQHIEAGISLCDAVNFLVEKYALVRTDQSGF
SACTHSQLINSIDILRARRATGLMTRDNYRTVNNITLGKHPEAKR

Download         Length: 378 bp

>T161344 NZ_CP071128:c3070582-3070166 [Mycobacterium tuberculosis]
ATGACCACGCGCTATTTGCTCGACAAATCAGCGGCTTACCGCGCGCACTTGCCCGCGGTCCGACATCGCTTGGAACCGTT
GATGGAACGCGGTCTACTGGCCCGGTGCGGCATTACCGATCTCGAGTTCGGAGTCTCGGCGCGTTCCCGCGAGGACCATC
GAACACTGGGCACCTACCGGCGTGACGCGCTCGAATACGTCAACACCCCCGACACCGTGTGGGTTCGTGCATGGGAGATC
CAAGAAGCATTGACCGACAAGGGATTTCACCGCTCGGTCAAGATCCCGGACTTGATCATTGCGGCGGTCGCCGAGCATCA
CGGCATACCCGTCATGCACTACGACCAAGACTTCGAACGCATCGCCGCCATCACACGGCAACCCGTGGAATGGGTGGTGG
CCCCAGGGACAGCGTGA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13592.40 Da        Isoelectric Point: 6.6255

>AT161344 WP_001295723.1 NZ_CP055070:c1795653-1795285 [Shigella flexneri]
VSDTLSGTTHPDDNDDHPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGRFRDADAYPLDQAFPLLMKQLKLMLTSG
ELNPRHQHTVTLYAKGLTCEADTLGSCGYVYLAVYPTPETKK

Download         Length: 369 bp

>AT161344 NZ_CP071128:c3070845-3070579 [Mycobacterium tuberculosis]
ATGCATCGCGGATATGCATTAGTAGTATGCTCTCCGGGTGTGACGCGCACCATGATCGACATCGATGACGACCTGCTCGC
TCGGGCCGCCAAGGAACTGGGTACCACGACAAAGAAAGACACCGTGCATGCCGCGCTGCGGGCCGCGTTGCGAGCCAGTG
CCGCGCGCTCGCTCATGAACCGGATGGCCGAGAACGCCACCGGAACCCAGGACGAAGCTCTGGTCAACGCAATGTGGCGA
GACGGCCACCCAGAGAACACGGCATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7I6H0K3

Antitoxin

Source ID Structure
AlphaFold DB S1NM52

References