Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4737668..4738184 Replicon chromosome
Accession NZ_CP055066
Organism Klebsiella pneumoniae strain SWHE1

Toxin (Protein)


Gene name relE Uniprot ID A0A2A2BGN7
Locus tag HUZ64_RS23110 Protein ID WP_009486548.1
Coordinates 4737668..4737952 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag HUZ64_RS23115 Protein ID WP_002886901.1
Coordinates 4737942..4738184 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HUZ64_RS23085 (4733085) 4733085..4733348 - 264 WP_014908078.1 PTS sugar transporter subunit IIB -
HUZ64_RS23090 (4733478) 4733478..4733651 + 174 WP_002886906.1 hypothetical protein -
HUZ64_RS23095 (4733654) 4733654..4734397 + 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
HUZ64_RS23100 (4734754) 4734754..4736892 + 2139 WP_002886904.1 anaerobic ribonucleoside-triphosphate reductase -
HUZ64_RS23105 (4737200) 4737200..4737664 + 465 WP_002886903.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
HUZ64_RS23110 (4737668) 4737668..4737952 - 285 WP_009486548.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
HUZ64_RS23115 (4737942) 4737942..4738184 - 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
HUZ64_RS23120 (4738262) 4738262..4740172 - 1911 WP_009486549.1 PRD domain-containing protein -
HUZ64_RS23125 (4740195) 4740195..4741349 - 1155 WP_020316350.1 lactonase family protein -
HUZ64_RS23130 (4741416) 4741416..4742156 - 741 WP_009486551.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11125.95 Da        Isoelectric Point: 10.4951

>T161334 WP_009486548.1 NZ_CP055066:c4737952-4737668 [Klebsiella pneumoniae]
MTYELEFDPRARREWQKPGETVKKQFKNKLQQIVQNPRIESTRLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

>T161334 NZ_CP071128:2321054-2321464 [Mycobacterium tuberculosis]
TTGGCTGAGCCACGGCGAGGAGACCTTTGGCTGGTCAGCCTCGGCGCCGCTCGCGCGGGTGAGCCCGGCAAGCATCGGCC
CGCGGTGGTCGTTTCCGTGGACGAGCTACTCACCGGAATCGACGACGAACTCGTTGTCGTCGTGCCGGTGTCAAGCTCGC
GCTCCCGCACCCCACTCCGGCCACCTGTCGCGCCCTCAGAAGGTGTAGCTGCCGATAGCGTCGCGGTGTGCCGCGGCGTC
CGCGCGGTCGCTCGTGCCCGACTCGTGGAGCGACTCGGCGCCCTCAAACCCGCCACGATGCGCGCAATCGAAAACGCCCT
GACCCTGATCCTCGGCCTCCCGACGGGACCTGAGCGCGGCGAGGCGGCGACCCATTCTCCCGTACGGTGGACGGGTGGCC
GGGACCCGTGA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT161334 WP_002886901.1 NZ_CP055066:c4738184-4737942 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp

>AT161334 NZ_CP071128:2320828-2321061 [Mycobacterium tuberculosis]
ATGTCTACATCCACGACGATTAGGGTTTCAACCCAGACTCGGGATCGTCTGGCCGCCCAAGCCCGCGAACGGGGAATCTC
GATGTCGGCTCTGCTCACCGAACTGGCCGCCCAGGCCGAGCGCCAGGCAATCTTCCGCGCCGAACGCGAGGCCTCGCACG
CCGAGACGACCACCCAGGCAGTCCGCGACGAGGACCGCGAGTGGGAGGGCACGGTAGGCGACGGCCTTGGCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2A2BGN7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References