Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) ykfI-yfjZ/CbtA-CbeA
Location 4657302..4657993 Replicon chromosome
Accession NZ_CP055066
Organism Klebsiella pneumoniae strain SWHE1

Toxin (Protein)


Gene name ykfI Uniprot ID A0A483YFJ1
Locus tag HUZ64_RS22780 Protein ID WP_025987721.1
Coordinates 4657302..4657643 (-) Length 114 a.a.

Antitoxin (Protein)


Gene name yfjZ Uniprot ID A0A2A5MHA6
Locus tag HUZ64_RS22785 Protein ID WP_019725272.1
Coordinates 4657667..4657993 (-) Length 109 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HUZ64_RS22765 (4654282) 4654282..4655517 - 1236 WP_124044824.1 hypothetical protein -
HUZ64_RS22770 (4655956) 4655956..4656327 - 372 WP_223369725.1 hypothetical protein -
HUZ64_RS22775 (4656354) 4656354..4657187 - 834 WP_025987720.1 DUF4942 domain-containing protein -
HUZ64_RS22780 (4657302) 4657302..4657643 - 342 WP_025987721.1 TA system toxin CbtA family protein Toxin
HUZ64_RS22785 (4657667) 4657667..4657993 - 327 WP_019725272.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
HUZ64_RS22790 (4658007) 4658007..4658483 - 477 WP_019725273.1 DNA repair protein RadC -
HUZ64_RS22795 (4658493) 4658493..4658939 - 447 WP_025987722.1 antirestriction protein -
HUZ64_RS22800 (4659151) 4659151..4659840 - 690 WP_009309812.1 hypothetical protein -
HUZ64_RS22805 (4660405) 4660405..4661295 - 891 WP_019725276.1 YfjP family GTPase -
HUZ64_RS22810 (4661378) 4661378..4662466 - 1089 WP_019725277.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 4642122..4679141 37019


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-107)

Antitoxin

Antitoxin CbeA

(8-107)


Sequences

Toxin        


Download         Length: 114 a.a.        Molecular weight: 12867.90 Da        Isoelectric Point: 8.5195

>T161333 WP_025987721.1 NZ_CP055066:c4657643-4657302 [Klebsiella pneumoniae]
MKTLPATIQRAAKPCPSPVTVWQMLLTRLLEQHYGLTLNDTPFSDETVIQEHINAGITLVDAVNFLVEKYELVRIDRRGF
NCQEQSPYLGAVDILRARQATGLLRQRHLPSIR

Download         Length: 342 bp

>T161333 NZ_CP071128:2258270-2258668 [Mycobacterium tuberculosis]
ATGATCGTCGACACCTCGGTCTGGATCGCATATCTCTCCACGTCAGAGTCGTTGGCCAGTCGCTGGCTAGCCGATCGCAT
TGCCGCTGACTCGACGGTGATCGTGCCCGAGGTGGTGATGATGGAGCTGCTGATCGGTAAGACCGATGAGGACACCGCCG
CACTGCGCCGACGGCTCCTGCAGCGATTCGCTATCGAACCGCTGGCCCCGGTCCGCGACGCGGAAGATGCCGCCGCCATT
CACCGGCGCTGTCGTCGCGGCGGCGACACCGTACGCAGCCTGATCGATTGCCAGGTGGCCGCGATGGCGTTGCGGATCGG
GGTCGCCGTGGCGCATCGTGATCGCGACTACGAGGCGATCCGCACACATTGCGGACTACGCACCGAGCCGTTGTTCTGA

Antitoxin


Download         Length: 109 a.a.        Molecular weight: 12276.01 Da        Isoelectric Point: 6.9560

>AT161333 WP_019725272.1 NZ_CP055066:c4657993-4657667 [Klebsiella pneumoniae]
MPLTDAIQWGLKRSFTPNFGARLVQEGNRLHYLADRANITGKFGDAECLKLEEAFPHFIRQMELMLSTGELNPRHAHSVT
LYHNAFTCEADTLGSCGYVYIVIYPTQR

Download         Length: 327 bp

>AT161333 NZ_CP071128:2258042-2258269 [Mycobacterium tuberculosis]
GTGTCACGGACCAACATCGAGATCGACGACGAACTCGTGGCCGCCGCACAGCGGATGTACCGACTCGATTCCAAGCGAAG
TGCCGTCGACCTCGCGCTGCGCCGGCTCGTGGGTGAACCGTTGGGCCGCGATGAGGCTTTGGCGCTGCAGGGCAGCGGTT
TCGACTTCAGCAACGATGAGATCGAATCGTTCTCGGATACGGACCGCAAGCTCGCCGACGAGTCGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A483YFJ1

Antitoxin

Source ID Structure
AlphaFold DB A0A2A5MHA6

References