Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vagCD/VapC-VagC
Location 100336..100988 Replicon plasmid unnamed1
Accession NZ_CP055062
Organism Klebsiella pneumoniae strain SWHE3

Toxin (Protein)


Gene name vagD Uniprot ID A0A8A2Q2K1
Locus tag HUZ66_RS26140 Protein ID WP_017901321.1
Coordinates 100563..100988 (+) Length 142 a.a.

Antitoxin (Protein)


Gene name vagC Uniprot ID A0A853H7M9
Locus tag HUZ66_RS26135 Protein ID WP_001261275.1
Coordinates 100336..100566 (+) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HUZ66_RS26130 (HUZ66_26060) 97507..100083 + 2577 WP_017901322.1 nuclease domain-containing protein -
HUZ66_RS26135 (HUZ66_26065) 100336..100566 + 231 WP_001261275.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
HUZ66_RS26140 (HUZ66_26070) 100563..100988 + 426 WP_017901321.1 type II toxin-antitoxin system VapC family toxin Toxin
HUZ66_RS26145 (HUZ66_26075) 101006..101974 + 969 WP_102097429.1 IS5 family transposase -
HUZ66_RS26150 (HUZ66_26080) 102033..102569 + 537 Protein_117 integrase core domain-containing protein -
HUZ66_RS26155 102622..102795 + 174 Protein_118 nuclease -
HUZ66_RS26160 (HUZ66_26085) 102982..104055 + 1074 WP_239635676.1 cache domain-containing protein -
HUZ66_RS26165 (HUZ66_26090) 104101..105069 - 969 WP_072096747.1 IS5 family transposase -
HUZ66_RS26170 (HUZ66_26095) 105128..105604 + 477 WP_239635677.1 GGDEF domain-containing protein -
HUZ66_RS26175 105696..105923 - 228 Protein_122 IS3 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid qnrB4 / blaDHA-1 / sul1 / blaTEM-1B / aac(3)-IId / qacE / dfrA5 / aph(3'')-Ib / aph(6)-Id / sul2 - 1..263057 263057


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(6-129)

Antitoxin

SpoVT-AbrB domain

(7-47)


Sequences

Toxin        


Download         Length: 142 a.a.        Molecular weight: 15412.91 Da        Isoelectric Point: 7.1364

>T161317 WP_017901321.1 NZ_CP055062:100563-100988 [Klebsiella pneumoniae]
MKKTWMLDTNICSFIMREQPAAVLKRLEQVVLRGDRIVVSAVTYAEMRFGATGPKASPRHIQLVDAFCARLDAILPWDRA
AVDATTDIRVALRLAGTPIGPNDTAIAGHAIAAGAILVTNNTREFERVPGLVLEDWVGFVE

Download         Length: 426 bp

>T161317 NZ_CP071128:c1230967-1230656 [Mycobacterium tuberculosis]
ATGCGACCTATCCACATCGCACAGCTTGACAAGGCTAGACCCGTCCTGATCCTTACCCGCGAGGTCGTACGTCCGCACCT
CACGAACGTCACCGTCGCCCCGATCACGACAACCGTGCGTGGGCTAGCCACCGAAGTCCCGGTAGACGCGGTGAACGGGC
TGAATCAACCGTCAGTCGTCAGCTGCGACAACATCCAAACGATCCCGGTGTGTGACCTTGGTCGTCAAATCGGCTACCTG
CTCGCGTCGCAGGAGCCGGCTCTAGCCGAGGCCATCGGCAACGCGTTCGACCTCGATTGGGTGGTGGCATAG

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8707.72 Da        Isoelectric Point: 4.3410

>AT161317 WP_001261275.1 NZ_CP055062:100336-100566 [Klebsiella pneumoniae]
MRTVSIFKNGNNRAIRLPRDLDFDGVSELEIVREGDSIILRPVRPTWGSFAQLDRADPDFMAEREDVVSDEGRFDP

Download         Length: 231 bp

>AT161317 NZ_CP071128:c1231287-1230967 [Mycobacterium tuberculosis]
ATGTACCTACCCTGGGGGGTCGTCCTCGCCGGCGGCGCGAACGGTTTTGGGGCGGGTGCATACCAAACTGGTACCATCTG
TGAAGTGAGTACACAGATTGCGGTTCGCTTGCCCGATGAGATTGTCGCGTTCATCGACGACGAAGTCCGGGGACAGCATG
CCCGTAGCCGTGCGGCTGTCGTGCTGCGGGCGCTGGAACGGGAACGCCGCCGTCGTCTCGCCGAACGCGACGCGGAGATC
CTCGCCACCAACACGTCAGCCACGGGTGATCTGGATACGCTGGCCGGCCACTGCGCTCGTACCGCCCTCGACATCGACTG
A

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A8A2Q2K1

Antitoxin

Source ID Structure
AlphaFold DB A0A853H7M9

References