Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) ykfI-yfjZ/CbtA-CbeA
Location 4640529..4641220 Replicon chromosome
Accession NZ_CP055061
Organism Klebsiella pneumoniae strain SWHE3

Toxin (Protein)


Gene name ykfI Uniprot ID A0A483YFJ1
Locus tag HUZ66_RS22595 Protein ID WP_025987721.1
Coordinates 4640529..4640870 (-) Length 114 a.a.

Antitoxin (Protein)


Gene name yfjZ Uniprot ID A0A2A5MHA6
Locus tag HUZ66_RS22600 Protein ID WP_019725272.1
Coordinates 4640894..4641220 (-) Length 109 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HUZ66_RS22580 (HUZ66_22535) 4637516..4638751 - 1236 WP_124044824.1 hypothetical protein -
HUZ66_RS22585 (HUZ66_22540) 4639183..4639554 - 372 WP_223369725.1 hypothetical protein -
HUZ66_RS22590 (HUZ66_22545) 4639581..4640414 - 834 WP_025987720.1 DUF4942 domain-containing protein -
HUZ66_RS22595 (HUZ66_22550) 4640529..4640870 - 342 WP_025987721.1 TA system toxin CbtA family protein Toxin
HUZ66_RS22600 (HUZ66_22555) 4640894..4641220 - 327 WP_019725272.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
HUZ66_RS22605 (HUZ66_22560) 4641234..4641710 - 477 WP_019725273.1 DNA repair protein RadC -
HUZ66_RS22610 (HUZ66_22565) 4641720..4642166 - 447 WP_025987722.1 antirestriction protein -
HUZ66_RS22615 (HUZ66_22570) 4642378..4643067 - 690 WP_009309812.1 hypothetical protein -
HUZ66_RS22620 (HUZ66_22575) 4643632..4644522 - 891 WP_019725276.1 YfjP family GTPase -
HUZ66_RS22625 (HUZ66_22580) 4644605..4645693 - 1089 WP_019725277.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 4623475..4662368 38893


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-107)

Antitoxin

Antitoxin CbeA

(8-107)


Sequences

Toxin        


Download         Length: 114 a.a.        Molecular weight: 12867.90 Da        Isoelectric Point: 8.5195

>T161313 WP_025987721.1 NZ_CP055061:c4640870-4640529 [Klebsiella pneumoniae]
MKTLPATIQRAAKPCPSPVTVWQMLLTRLLEQHYGLTLNDTPFSDETVIQEHINAGITLVDAVNFLVEKYELVRIDRRGF
NCQEQSPYLGAVDILRARQATGLLRQRHLPSIR

Download         Length: 342 bp

>T161313 NZ_CP071128:c755771-755334 [Mycobacterium tuberculosis]
ATGATAGTGCTCGACACCACCGTCCTCGTCTATGCCAAAGGCGCCGAGCATCCACTCCGCGATCCCTGCCGCGATCTCGT
CGCGGCAATCGCCGACGAACGCATCGCTGCGACCACCACCGCCGAGGTGATCCAGGAGTTCGTCCACGTACGCGCCCGCC
GGCGCGACCGCAGCGACGCCGCCGCGCTGGGCCGTGTGACTATGCCGAACTGCTCTCGCCGCTACTCACCATCAATCGAG
GCCACCTCGAAGCGCGGCCTGACGCTGTTCGAGACAACGCCAGGGCTTGAAGCCTGCGACGCGGTGCTCGCGGCGGTTGC
CGCAAGCGCCGGCGCGACCGCTCTTGTCTCGGCTGACCCGGCGTTCGCCGATCTGTCGGATGTCGTGCACGTCATTCCCG
ACGCGGCCGGGATGGTCAGCCTGCTCGGCGACCGCTGA

Antitoxin


Download         Length: 109 a.a.        Molecular weight: 12276.01 Da        Isoelectric Point: 6.9560

>AT161313 WP_019725272.1 NZ_CP055061:c4641220-4640894 [Klebsiella pneumoniae]
MPLTDAIQWGLKRSFTPNFGARLVQEGNRLHYLADRANITGKFGDAECLKLEEAFPHFIRQMELMLSTGELNPRHAHSVT
LYHNAFTCEADTLGSCGYVYIVIYPTQR

Download         Length: 327 bp

>AT161313 NZ_CP071128:c756022-755768 [Mycobacterium tuberculosis]
ATGAGCATGCGTCTGGCGCATCGGCTCCAGATCCTGCTCGACGACGAGTGCCACCGCCGCATCACCGCGGTGGCGCGCGA
GCGAGGCGTCCCGGTCGCAACCGTCGTGCGTGAGGCCATTGATCGAGGCCTCGTCAGCCCCGCCGGTCGCCGCAAGTCCG
CGGGCAGGCGCCTGCTCGACGCCGCCGACATGTCCGTTCCCGAGCCGCGGGAGCTGAAGCAGGAACTCGAGGCCCTCCGG
GCGCGCCGCGGATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A483YFJ1

Antitoxin

Source ID Structure
AlphaFold DB A0A2A5MHA6

References