Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 784175..784832 Replicon chromosome
Accession NZ_CP055057
Organism Klebsiella pneumoniae strain SWHE4

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag HUZ67_RS03910 Protein ID WP_002916310.1
Coordinates 784422..784832 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag HUZ67_RS03905 Protein ID WP_002916312.1
Coordinates 784175..784441 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HUZ67_RS03880 (HUZ67_03875) 779383..780816 - 1434 WP_002916322.1 6-phospho-beta-glucosidase BglA -
HUZ67_RS03885 (HUZ67_03880) 780935..781663 - 729 WP_002916321.1 MurR/RpiR family transcriptional regulator -
HUZ67_RS03890 (HUZ67_03885) 781713..782024 + 312 WP_002916319.1 N(4)-acetylcytidine aminohydrolase -
HUZ67_RS03895 (HUZ67_03890) 782188..782847 + 660 WP_002916317.1 hemolysin III family protein -
HUZ67_RS03900 (HUZ67_03895) 782946..783929 - 984 WP_002916313.1 tRNA-modifying protein YgfZ -
HUZ67_RS03905 (HUZ67_03900) 784175..784441 + 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
HUZ67_RS03910 (HUZ67_03905) 784422..784832 + 411 WP_002916310.1 protein YgfX Toxin
HUZ67_RS03915 (HUZ67_03910) 784839..785360 - 522 WP_004144730.1 flavodoxin FldB -
HUZ67_RS03920 (HUZ67_03915) 785461..786357 + 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
HUZ67_RS03925 (HUZ67_03920) 786380..787093 + 714 WP_004174456.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
HUZ67_RS03930 (HUZ67_03925) 787099..788832 + 1734 WP_032105216.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T161279 WP_002916310.1 NZ_CP055057:784422-784832 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

>T161279 NZ_CP071127:c2854678-2854259 [Mycobacterium tuberculosis]
GTGACGGCACTGCTCGATGTCAATGTGCTGATCGCGCTGGGCTGGCCGAATCACGTTCACCATGCGGCCGCGCAGCGATG
GTTCACGCAGTTCTCCTCGAATGGGTGGGCCACCACGCCGATCACCGAGGCAGGGTATGTCCGAATTTCAAGCAATCGCA
GTGTGATGCAGGTGTCGACCACGCCGGCTATCGCGATCGCTCAGTTGGCGGCGATGACTTCTCTTGCCGGGCACACGTTT
TGGCCTGACGATGTGCCACTGATCGTTGGGAGCGCCGGCGATCGCGATGCGGTGTCCAACCACCGTCGGGTCACCGACTG
CCATCTCATCGCCTTGGCCGCGCGCTACGGGGGCCGGTTGGTCACATTCGATGCCGCACTGGCCGATTCAGCATCCGCAG
GCCTCGTCGAGGTGTTGTAG

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT161279 WP_002916312.1 NZ_CP055057:784175-784441 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT161279 NZ_CP071127:c2854899-2854675 [Mycobacterium tuberculosis]
ATGCGCACCACGTTGCAGATTGATGATGATGTTCTAGAAGATGCTCGTAGCATCGCGCGGTCGGAGGGCAAGTCAGTCGG
CGCGGTAATTTCTGAGTTGGCGCGTAGGTCGCTCCGTCCGGTTGGGATTGTCGAGGTTGACGGATTTCCGGTTTTTGATG
TTCCGCCGGATGCGCCGACGGTGACTTCCGAGGATGTCGTCCGCGCGCTCGAGGACGACGTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GSW7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References