Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | vagCD/VapC-VagC |
| Location | 108294..108937 | Replicon | plasmid unnamed1 |
| Accession | NZ_CP055056 | ||
| Organism | Shigella dysenteriae strain SWHEFF_49 | ||
Toxin (Protein)
| Gene name | vagD | Uniprot ID | - |
| Locus tag | HUZ68_RS24855 | Protein ID | WP_063073410.1 |
| Coordinates | 108521..108937 (+) | Length | 139 a.a. |
Antitoxin (Protein)
| Gene name | vagC | Uniprot ID | A0A3Q0N5I0 |
| Locus tag | HUZ68_RS24850 | Protein ID | WP_063073411.1 |
| Coordinates | 108294..108524 (+) | Length | 77 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| HUZ68_RS24815 (103718) | 103718..104224 | - | 507 | WP_001505085.1 | hypothetical protein | - |
| HUZ68_RS24820 (104215) | 104215..104919 | + | 705 | WP_239594266.1 | IS6-like element IS26 family transposase | - |
| HUZ68_RS24825 (105308) | 105308..105733 | + | 426 | WP_024198578.1 | hypothetical protein | - |
| HUZ68_RS24830 (105750) | 105750..106613 | + | 864 | WP_050858821.1 | toll/interleukin-1 receptor domain-containing protein | - |
| HUZ68_RS24835 (106856) | 106856..107245 | - | 390 | Protein_125 | ISNCY family transposase | - |
| HUZ68_RS24840 (107310) | 107310..108014 | + | 705 | WP_001067848.1 | IS6-like element IS26 family transposase | - |
| HUZ68_RS24845 (108161) | 108161..108337 | - | 177 | Protein_127 | hypothetical protein | - |
| HUZ68_RS24850 (108294) | 108294..108524 | + | 231 | WP_063073411.1 | type II toxin-antitoxin system VapB family antitoxin | Antitoxin |
| HUZ68_RS24855 (108521) | 108521..108937 | + | 417 | WP_063073410.1 | type II toxin-antitoxin system VapC family toxin | Toxin |
| HUZ68_RS24860 (109011) | 109011..110573 | + | 1563 | WP_063073409.1 | AAA family ATPase | - |
| HUZ68_RS24865 (110558) | 110558..111580 | + | 1023 | WP_063073408.1 | hypothetical protein | - |
| HUZ68_RS24870 (111867) | 111867..112097 | + | 231 | WP_001261276.1 | type II toxin-antitoxin system VapB family antitoxin | - |
| HUZ68_RS24875 (112094) | 112094..112189 | + | 96 | Protein_133 | VapC toxin family PIN domain ribonuclease | - |
| HUZ68_RS24880 (112248) | 112248..113032 | - | 785 | Protein_134 | IS21-like element helper ATPase IstB | - |
| HUZ68_RS24885 (113032) | 113032..113685 | - | 654 | Protein_135 | IS21-like element IS21 family transposase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Conjugative plasmid | - | - | 1..117256 | 117256 | |
| - | inside | IScluster/Tn | - | - | 106856..113673 | 6817 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 139 a.a. Molecular weight: 15167.53 Da Isoelectric Point: 7.8882
>T161274 WP_063073410.1 NZ_CP055056:108521-108937 [Shigella dysenteriae]
VNKTYMLDTNICSFIMREQPEAVLKRLEQAVLRGHRIVVSAITYSEMRFGATGPKASPRHVQLVDAFCTRLDAILPWDRA
AVDATTEIKVALRLAGTPIGPNDTAIAGHSIAAGAVLVTNNTREFERVPGLVLEDWIR
VNKTYMLDTNICSFIMREQPEAVLKRLEQAVLRGHRIVVSAITYSEMRFGATGPKASPRHVQLVDAFCTRLDAILPWDRA
AVDATTEIKVALRLAGTPIGPNDTAIAGHSIAAGAVLVTNNTREFERVPGLVLEDWIR
Download Length: 417 bp
>T161274 NZ_CP071127:2258269-2258667 [Mycobacterium tuberculosis]
ATGATCGTCGACACCTCGGTCTGGATCGCATATCTCTCCACGTCAGAGTCGTTGGCCAGTCGCTGGCTAGCCGATCGCAT
TGCCGCTGACTCGACGGTGATCGTGCCCGAGGTGGTGATGATGGAGCTGCTGATCGGTAAGACCGATGAGGACACCGCCG
CACTGCGCCGACGGCTCCTGCAGCGATTCGCTATCGAACCGCTGGCCCCGGTCCGCGACGCGGAAGATGCCGCCGCCATT
CACCGGCGCTGTCGTCGCGGCGGCGACACCGTACGCAGCCTGATCGATTGCCAGGTGGCCGCGATGGCGTTGCGGATCGG
GGTCGCCGTGGCGCATCGTGATCGCGACTACGAGGCGATCCGCACACATTGCGGACTACGCACCGAGCCGTTGTTCTGA
ATGATCGTCGACACCTCGGTCTGGATCGCATATCTCTCCACGTCAGAGTCGTTGGCCAGTCGCTGGCTAGCCGATCGCAT
TGCCGCTGACTCGACGGTGATCGTGCCCGAGGTGGTGATGATGGAGCTGCTGATCGGTAAGACCGATGAGGACACCGCCG
CACTGCGCCGACGGCTCCTGCAGCGATTCGCTATCGAACCGCTGGCCCCGGTCCGCGACGCGGAAGATGCCGCCGCCATT
CACCGGCGCTGTCGTCGCGGCGGCGACACCGTACGCAGCCTGATCGATTGCCAGGTGGCCGCGATGGCGTTGCGGATCGG
GGTCGCCGTGGCGCATCGTGATCGCGACTACGAGGCGATCCGCACACATTGCGGACTACGCACCGAGCCGTTGTTCTGA
Antitoxin
Download Length: 77 a.a. Molecular weight: 8688.84 Da Isoelectric Point: 4.6310
>AT161274 WP_063073411.1 NZ_CP055056:108294-108524 [Shigella dysenteriae]
MRTVSIFKNGNNRAIRLPRDLDFEGVSELEIVREGDSIILRPVRPTWGSFAKLEKADPDFMAEREDVVTDEGRVNL
MRTVSIFKNGNNRAIRLPRDLDFEGVSELEIVREGDSIILRPVRPTWGSFAKLEKADPDFMAEREDVVTDEGRVNL
Download Length: 231 bp
>AT161274 NZ_CP071127:2258041-2258268 [Mycobacterium tuberculosis]
GTGTCACGGACCAACATCGAGATCGACGACGAACTCGTGGCCGCCGCACAGCGGATGTACCGACTCGATTCCAAGCGAAG
TGCCGTCGACCTCGCGCTGCGCCGGCTCGTGGGTGAACCGTTGGGCCGCGATGAGGCTTTGGCGCTGCAGGGCAGCGGTT
TCGACTTCAGCAACGATGAGATCGAATCGTTCTCGGATACGGACCGCAAGCTCGCCGACGAGTCGTAG
GTGTCACGGACCAACATCGAGATCGACGACGAACTCGTGGCCGCCGCACAGCGGATGTACCGACTCGATTCCAAGCGAAG
TGCCGTCGACCTCGCGCTGCGCCGGCTCGTGGGTGAACCGTTGGGCCGCGATGAGGCTTTGGCGCTGCAGGGCAGCGGTT
TCGACTTCAGCAACGATGAGATCGAATCGTTCTCGGATACGGACCGCAAGCTCGCCGACGAGTCGTAG
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|