Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 4060910..4061751 Replicon chromosome
Accession NZ_CP055055
Organism Shigella dysenteriae strain SWHEFF_49

Toxin (Protein)


Gene name yeeV Uniprot ID A0A1M0WJM1
Locus tag HUZ68_RS19375 Protein ID WP_000854822.1
Coordinates 4060910..4061293 (-) Length 128 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A1M0CWL2
Locus tag HUZ68_RS19380 Protein ID WP_053271974.1
Coordinates 4061383..4061751 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HUZ68_RS19345 (4056555) 4056555..4058396 + 1842 WP_000437371.1 RNA polymerase sigma factor RpoD -
HUZ68_RS19350 (4058475) 4058475..4058981 - 507 WP_000228930.1 G/U mismatch-specific DNA glycosylase -
HUZ68_RS19360 (4059280) 4059280..4060125 - 846 WP_001280435.1 DUF4942 domain-containing protein -
HUZ68_RS19365 (4060222) 4060222..4060419 - 198 WP_000839263.1 DUF957 domain-containing protein -
HUZ68_RS19370 (4060431) 4060431..4060919 - 489 WP_001177592.1 DUF5983 family protein -
HUZ68_RS19375 (4060910) 4060910..4061293 - 384 WP_000854822.1 type IV toxin-antitoxin system cytoskeleton-binding toxin CbtA Toxin
HUZ68_RS19380 (4061383) 4061383..4061751 - 369 WP_053271974.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
HUZ68_RS19385 (4061831) 4061831..4062052 - 222 WP_000692312.1 DUF987 domain-containing protein -
HUZ68_RS19390 (4062121) 4062121..4062597 - 477 WP_001186747.1 RadC family protein -
HUZ68_RS19395 (4062612) 4062612..4063097 - 486 WP_000214317.1 antirestriction protein -
HUZ68_RS19400 (4063188) 4063188..4064006 - 819 WP_001234702.1 DUF932 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 128 a.a.        Molecular weight: 14295.32 Da        Isoelectric Point: 8.2830

>T161266 WP_000854822.1 NZ_CP055055:c4061293-4060910 [Shigella dysenteriae]
MKTLPVLPGQAASSRPSPVEIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKHQESKRCN

Download         Length: 384 bp

>T161266 NZ_CP071127:c1947415-1947026 [Mycobacterium tuberculosis]
GTGATCGTGTTGGACGCCTCGGCGGCCGTCGAGCTCATGCTCACGACGCCGGCGGGTGCGGCGGTCGCCCGGCGCTTGCG
GGGCGAAACCGTGCACGCCCCTGCACATTTCGATGTCGAGGTGATCGGGGCGATACGTCAAGCGGTCGTGCGTCAGCTGA
TCAGCGATCATGAAGGACTCGTCGTGGTTGTCAACTTCCTTAGCCTGCCCGTTCGGCGTTGGCCGTTAAAGCCATTCACC
CAGCGTGCCTACCAACTTCGGTCCACTCATACCGTGGCCGATGGAGCCTACGTCGCCCTCGCCGAGGGCCTCGGCGTACC
GCTTATCACTTGCGACGGGCGACTTGCCCAATCCCATGGCCATAATGCGGAGATCGAGCTTGTCGCCTGA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13679.41 Da        Isoelectric Point: 6.4758

>AT161266 WP_053271974.1 NZ_CP055055:c4061751-4061383 [Shigella dysenteriae]
VSDTFSGTTHPDDNHDRPWWGLPCTVTPCFGARLVQEGNRLHYLTDRAGIRGRFSDADANHLDQAFPLLMKQLELMLTSS
ELNPHRQNTVTLYVKGLTCHADTLGSCGYVYLAVYPTPEMKN

Download         Length: 369 bp

>AT161266 NZ_CP071127:c1947639-1947412 [Mycobacterium tuberculosis]
ATGTCCGCCATGGTTCAGATCCGCAACGTTCCCGACGAGCTTCTCCACGAGCTGAAGGCCCGCGCAGCGGCGCAACGGAT
GAGCCTGAGCGATTTCCTCCTAGCACGGCTTGCCGAGATCGCGGAAGAACCGGCCCTCGACGACGTTCTCGACCGTCTAG
CGGCACTGCCGCGCCGGGATCTCGGCGCGAGCGCAGCCGAGCTTGTTGACGAGGCTCGATCTGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1M0WJM1

Antitoxin

Source ID Structure
AlphaFold DB A0A1M0CWL2

References