Detailed information of TA system TA161251

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mosAT/AbiEii-AbiEi
• Location: 959900..961589
• Replicon: chromosome
• Accession: NZ_CP055055
• Organism: Shigella dysenteriae strain SWHEFF_49

Toxin (Protein)

• Gene name: mosT
• Uniprot ID: A0A3L4JYS0
• Locus tag: HUZ68_RS04620
• Protein ID: WP_033815309.1
• Coordinates: 960669..961589 (+)
• Length: 307 a.a.

Antitoxin (Protein)

• Gene name: mosA
• Uniprot ID: -
• Locus tag: HUZ68_RS04615
• Protein ID: WP_069913661.1
• Coordinates: 959900..960682 (+)
• Length: 261 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HUZ68_RS04590 (956465)	956465..956716	+	252	Protein_891	IS200/IS605 family transposase	-
HUZ68_RS04595 (956908)	956908..957102	-	195	WP_152918890.1	hypothetical protein	-
HUZ68_RS04610 (958907)	958907..959584	-	678	WP_239594047.1	hypothetical protein	-
HUZ68_RS04615 (959900)	959900..960682	+	783	WP_069913661.1	type IV toxin-antitoxin system AbiEi family antitoxin domain-containing protein	Antitoxin
HUZ68_RS04620 (960669)	960669..961589	+	921	WP_033815309.1	nucleotidyl transferase AbiEii/AbiGii toxin family protein	Toxin
HUZ68_RS04625 (961994)	961994..962893	-	900	WP_069913659.1	LysR family transcriptional regulator	-
HUZ68_RS04630 (962992)	962992..963714	+	723	WP_047670827.1	SDR family oxidoreductase	-
HUZ68_RS04635 (963880)	963880..964158	+	279	WP_001695465.1	hypothetical protein	-
HUZ68_RS04640 (964860)	964860..965762	-	903	WP_122986360.1	LysR family transcriptional regulator	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	925118..965762	40644

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Nucleotidyl transferase AbiEii toxin, Type IV TA system (14-261)

Antitoxin

• Transcriptional regulator, AbiEi 3 antitoxin, Type IV TA system (96-247)

Sequences

Toxin

Protein

• Length: 307 a.a.
• Molecular weight: 34580.96 Da
• Isoelectric Point: 6.9554

>T161251 WP_033815309.1 NZ_CP055055:960669-961589 [Shigella dysenteriae]
MDLRDSYARQVKLLMAALPHVAKESCFALKGGTAINLFVQDFPRLSVDIDLAYKSFADRDTDLAAINDALKRITASLNSK
PGITAIRQENKADEKRIIVNTADAKIKIEVSPVWRGLLLPPAEMSVCERVEMEYGFTTMSVVSLADLYGGKICAALDRQH
PRDLFDVLNMLEKPGLMREIFDGFICYLAGHPRPIAELLAPNWDTDRIATLYAQEFSGMTQQETSLESLLSVTTLLPQAL
KSHLTDLDREFLLSFKQNSPDWSRYRYPEIQHLPAIRWKQRNLAVLKDKNPAKYVAAVNKLERVLE

Nucleotide

• Length: 921 bp

>T161251 NZ_CP071127:c753366-752983 [Mycobacterium tuberculosis]
TTGGCGGCTGCAACGACAACCGGAACCCACCGAGGCCTGGAACTCCGCGCTGCTCAGCGGGCCGTCGGGTCGTGCGAACC
GCAACGAGCCGAGTTCTGCCGATCAGCGCGGAATGCGGACGAGTTCGACCAGATGAGCCGGATGTTTGGTGACGTCTACC
CCGATGTGCCAGTGCCGAAATCCGTGTGGCGGTGGATCGATTCGGCACAGCACCGCCTCGCCCGGGCGGGAGCGGTGGGT
GCCCTGTCGGTTGTCGATCTGCTGATCTGCGACACTGCGGCGGCCAGGGGCCTAGTAGTCCTCCACGACGATGCCGACTA
CGAACTCGCAGAGCGTCACCTTCCCGACATCAGAGTGCGGAGGGTCGTCAGCGCCGACGACTAG

Antitoxin

Protein

• Length: 261 a.a.
• Molecular weight: 29139.35 Da
• Isoelectric Point: 8.6100

>AT161251 WP_069913661.1 NZ_CP055055:959900-960682 [Shigella dysenteriae]
MPNYLNWLMQNTLPGQVLLQSWLTRNGVDRKLSYLYVQNGWLRRIAHGVYCRTGREPDWVDAVYCLQTQWEKPVRVAGLT
SLALQGHAHYTEPGRPQVWLALPAYVKLPGWFAAFEQSATFITLYTSGLTADVTSFTTELKIGDRQLAGSALELAAYEIA
CGVPSLISFEHADALFQGLNLLSPRKLQALLRASHSIKTNRVMLFLARRNGHPYFQYLDQSGIETGTGKRQIIPGGWLEP
DYQITVPRAFKPEGVEDGSA

Nucleotide

• Length: 783 bp

>AT161251 NZ_CP071127:c753616-753461 [Mycobacterium tuberculosis]
GTGTCGGTGACCCAGATCGACCTCGACGACGAAGCGCTGGCCGATGTGATGCGCATCGCCGCCGTGCACACAAAGAAGGA
AGCCGTGAACCTCGCGATGCGCGATTACGTCGAACGGTTTCGGCGCATCGAGGCCCTGGCCCGCTCGCGCGAGTAG

Structures

Toxin

• AlphaFold DB: A0A3L4JYS0