Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) chpSB/PRK09812-ChpS
Location 418048..418643 Replicon chromosome
Accession NZ_CP055055
Organism Shigella dysenteriae strain SWHEFF_49

Toxin (Protein)


Gene name chpB Uniprot ID U9Y4M4
Locus tag HUZ68_RS02135 Protein ID WP_000239579.1
Coordinates 418293..418643 (+) Length 117 a.a.

Antitoxin (Protein)


Gene name chpS Uniprot ID U9Y2K1
Locus tag HUZ68_RS02130 Protein ID WP_001223208.1
Coordinates 418048..418299 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HUZ68_RS02120 (413713) 413713..417492 + 3780 WP_239594017.1 autotransporter assembly complex protein TamB -
HUZ68_RS02125 (417495) 417495..417836 + 342 WP_001219160.1 gamma-glutamylcyclotransferase -
HUZ68_RS02130 (418048) 418048..418299 + 252 WP_001223208.1 type II toxin-antitoxin system antitoxin ChpS Antitoxin
HUZ68_RS02135 (418293) 418293..418643 + 351 WP_000239579.1 endoribonuclease toxin ChpB Toxin
HUZ68_RS02140 (418723) 418723..419253 - 531 WP_239594018.1 inorganic diphosphatase -
HUZ68_RS02145 (419563) 419563..420519 + 957 WP_000265942.1 galactofuranose ABC transporter substrate-binding protein YtfQ -
HUZ68_RS02150 (420659) 420659..422161 + 1503 WP_000205813.1 sugar ABC transporter ATP-binding protein -
HUZ68_RS02155 (422175) 422175..423197 + 1023 WP_033815210.1 ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(8-114)

Antitoxin

SpoVT-AbrB domain

(6-49)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12511.45 Da        Isoelectric Point: 5.6219

>T161249 WP_000239579.1 NZ_CP055055:418293-418643 [Shigella dysenteriae]
MVKKSEFERGDIVLVGFDPASGHEQQGAGRPALVLSVQAFNQLGMTLVAPITQGGNFARYAGFSVPLHCEEGDVHGVVLV
NQVRMMDLRARLAKRIGLAADEVVEEALLRLQAVVE

Download         Length: 351 bp

>T161249 NZ_CP071127:716663-717058 [Mycobacterium tuberculosis]
ATGGTGATCGACACGTCCGCGCTCGTTGCGATGCTCAGCGACGAGCCAGACGCAGAGCGGTTCGAGGCCGCCGTCGAAGC
CGACCACATCCGGCTGATGTCGACGGCGTCTTACCTGGAAACGGCACTCGTGATAGAAGCCCGCTTCGGTGAACCGGGCG
GACGTGAGCTGGATCTGTGGCTTCATCGCGCCGCGGTCGACCTTGTTGCCGTGCATGCCGACCAAGCGGATGCCGCGCGC
GCCGCCTACCGCACGTACGGCAAGGGAAGGCATCGTGCGGGGCTCAACTACGGCGACTGCTTCTCATACGGCCTCGCCAA
GATCAGCGGCCAGCCACTCCTGTTCAAGGGCGAAGATTTCCAACACACCGACATCGCCACGGTCGCGCTGCCCTAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9271.58 Da        Isoelectric Point: 4.4201

>AT161249 WP_001223208.1 NZ_CP055055:418048-418299 [Shigella dysenteriae]
MRITIKRWGNSAGMVIPNIVMKELNLQPGQSVEAQVSNNQLILTPISRRYSLDELLAQCDMNAAELSEQDVWGKSTPAGD
EIW

Download         Length: 252 bp

>AT161249 NZ_CP071127:716409-716663 [Mycobacterium tuberculosis]
ATGGCGCTGAGTATCAAGCACCCGGAAGCCGACCGGCTCGCGCGAGCGCTTGCGGCGCGCACCGGCGAGACGTTGACCGA
GGCAGTGGTTACCGCGTTGCGCGAGCGGCTCGCTCGTGAGACTGGGCGTGCCCGTGTTGTCCCGTTGCGCGACGAGCTTG
CCGCGATTCGGCACCGGTGCGCAGCGTTGCCGGTGGTCGACAACCGGTCCGCTGAGGCGATTCTCGGCTATGACGAGCGC
GGATTGCCGGCCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0Y8A8

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LQ26

References