Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RelE-RHH
Location 43221..43768 Replicon plasmid unnamed1
Accession NZ_CP055053
Organism Shigella dysenteriae strain SWHEFF_51

Toxin (Protein)


Gene name parE Uniprot ID G7QEJ9
Locus tag HUZ69_RS24410 Protein ID WP_001384452.1
Coordinates 43221..43499 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID K4JYR0
Locus tag HUZ69_RS24415 Protein ID WP_000079928.1
Coordinates 43499..43768 (-) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HUZ69_RS24375 (38660) 38660..39439 - 780 WP_020219164.1 hypothetical protein -
HUZ69_RS24380 (39452) 39452..39952 - 501 WP_020219165.1 HEPN family nuclease -
HUZ69_RS24385 (40226) 40226..40486 + 261 WP_000371882.1 hypothetical protein -
HUZ69_RS24390 (40483) 40483..41073 + 591 WP_020219166.1 hypothetical protein -
HUZ69_RS24395 (41091) 41091..41438 - 348 WP_194161622.1 DUF6404 family protein -
HUZ69_RS24400 (41728) 41728..42210 - 483 WP_194161623.1 hypothetical protein -
HUZ69_RS24405 (42327) 42327..43175 - 849 WP_020219167.1 3'-5' exonuclease -
HUZ69_RS24410 (43221) 43221..43499 - 279 WP_001384452.1 type II toxin-antitoxin system toxin YacB Toxin
HUZ69_RS24415 (43499) 43499..43768 - 270 WP_000079928.1 type II toxin-antitoxin system antitoxin YacA Antitoxin
HUZ69_RS24420 (43841) 43841..43981 - 141 WP_012512742.1 hypothetical protein -
HUZ69_RS24425 (44682) 44682..45539 - 858 WP_019842754.1 incFII family plasmid replication initiator RepA -
HUZ69_RS24430 (45532) 45532..46014 - 483 WP_074149688.1 hypothetical protein -
HUZ69_RS24435 (46007) 46007..46054 - 48 WP_229471593.1 hypothetical protein -
HUZ69_RS24440 (46045) 46045..46296 + 252 WP_223195197.1 replication protein RepA -
HUZ69_RS24445 (46313) 46313..46570 - 258 WP_000083845.1 replication regulatory protein RepA -
HUZ69_RS24450 (46833) 46833..46979 - 147 Protein_47 Hok/Gef family protein -
- (47023) 47023..47084 + 62 NuclAT_1 - -
- (47023) 47023..47084 + 62 NuclAT_1 - -
- (47023) 47023..47084 + 62 NuclAT_1 - -
- (47023) 47023..47084 + 62 NuclAT_1 - -
HUZ69_RS24455 (47668) 47668..47880 - 213 WP_032084501.1 hypothetical protein -
HUZ69_RS24460 (48014) 48014..48574 - 561 WP_063073483.1 fertility inhibition protein FinO -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid - - 1..117256 117256


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-91)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10762.38 Da        Isoelectric Point: 8.4615

>T161243 WP_001384452.1 NZ_CP055053:c43499-43221 [Shigella dysenteriae]
MEIFWTMLASQDRKRIREYIAEQNLMAAIELDERIGYSASSLAGQPYKGRNGRVEGTRELVIHPHFVLVYEVDSQWGKVY
ILRVLHTAQKWP

Download         Length: 279 bp

>T161243 NZ_CP071127:c640640-640227 [Mycobacterium tuberculosis]
GTGAGAGCATCGCCCACTTCGCCGCCGGAGCAGGTGGTCGTCGACGCGAGTGCCATGGTGGATCTACTGGCTCGCACTAG
CGATCGGTGCTCTGCGGTGCGCGCGCGGCTGGCTCGGACCGCGATGCACGCGCCGGCGCACTTCGATGCAGAGGTGTTGT
CGGCGCTGGGGCGCATGCAGCGCGCCGGCGCACTCACCGTTGCCTATGTCGATGCGGCACTGGAGGAGTTGCGACAGGTG
CCGGTGACTCGACACGGTCTTTCGTCGCTGCTTGCTGGAGCGTGGTCGCGCCGCGACACCCTCCGCCTGACCGATGCCCT
CTACGTCGAGCTGGCCGAAACGGCAGGTCTGGTGTTGTTGACCACCGACGAAAGATTGGCACGCGCCTGGCCCTCGGCTC
ACGCCATCGGCTGA

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 10175.50 Da        Isoelectric Point: 7.3210

>AT161243 WP_000079928.1 NZ_CP055053:c43768-43499 [Shigella dysenteriae]
MAQVNMSLRIDAELKDAFMAAAKSMDRNGSQLIRDFMRQTVERQHNTWFRDQVAAGRQQLEHGDVLPHDMVESSAAAWRD
EMSRKVAGK

Download         Length: 270 bp

>AT161243 NZ_CP071127:c640903-640637 [Mycobacterium tuberculosis]
TTGTTGAGCCGGCGCACGAAAACGATCGTTGTGTGTACATTGGTGTGTATGGCTCGGTTGAACGTGTATGTGCCCGACGA
ATTGGCGGAGCGCGCCAGGGCGCGGGGCTTGAACGTCTCGGCGCTGACTCAGGCCGCGATCAGTGCCGAGTTGGAGAACT
CCGCAACCGATGCGTGGCTTGAGGGGTTGGAACCCAGAAGCACCGGCGCTCGGCATGATGACGTGCTGGGTGCGATCGAT
GCCGCTCGCGATGAGTTCGAAGCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829CL36

Antitoxin

Source ID Structure
AlphaFold DB A0A5W2J4D0

References