Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 3849844..3850498 Replicon chromosome
Accession NZ_CP055052
Organism Shigella dysenteriae strain SWHEFF_51

Toxin (Protein)


Gene name cptA Uniprot ID S1EEB2
Locus tag HUZ69_RS18390 Protein ID WP_000244777.1
Coordinates 3849844..3850251 (-) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S1PPB1
Locus tag HUZ69_RS18395 Protein ID WP_000354046.1
Coordinates 3850232..3850498 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HUZ69_RS18370 (3845801) 3845801..3847534 - 1734 WP_000813236.1 single-stranded-DNA-specific exonuclease RecJ -
HUZ69_RS18375 (3847540) 3847540..3848250 - 711 WP_000715218.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
HUZ69_RS18380 (3848275) 3848275..3849171 - 897 WP_000806630.1 site-specific tyrosine recombinase XerD -
HUZ69_RS18385 (3849283) 3849283..3849804 + 522 WP_097450158.1 flavodoxin FldB -
HUZ69_RS18390 (3849844) 3849844..3850251 - 408 WP_000244777.1 protein YgfX Toxin
HUZ69_RS18395 (3850232) 3850232..3850498 - 267 WP_000354046.1 FAD assembly factor SdhE Antitoxin
HUZ69_RS18400 (3850741) 3850741..3851721 + 981 WP_000886100.1 tRNA-modifying protein YgfZ -
HUZ69_RS18405 (3851798) 3851798..3852457 - 660 WP_000250270.1 hemolysin III family protein -
HUZ69_RS18410 (3852621) 3852621..3852932 - 312 WP_001182957.1 N(4)-acetylcytidine aminohydrolase -
HUZ69_RS18415 (3852977) 3852977..3854410 + 1434 WP_023308281.1 6-phospho-beta-glucosidase BglA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 16031.96 Da        Isoelectric Point: 11.5202

>T161238 WP_000244777.1 NZ_CP055052:c3850251-3849844 [Shigella dysenteriae]
VVLWQSDLRVSWRAQWLSLLIHGLVAAVILLMPWPLSYTPLWMVLLSLVVFDCVRSQRRINARQGEIRLLMDGRLRWQGQ
EWSIVKAPWMIKSGMMLRLRSDGGKRQHLWLAADSMDEAEWRDLRRILLQQETQR

Download         Length: 408 bp

>T161238 NZ_CP071127:71821-72222 [Mycobacterium tuberculosis]
GTGGATGAATGTGTAGTCGACGCGGCGGCCGTGGTTGACGCTCTCGCCGGCAAGGGCGCCAGCGCGATCGTTCTGCGCGG
TTTGCTCAAGGAGTCGATTTCTAACGCGCCGCATTTGCTGGACGCAGAGGTCGGACATGCACTCCGCCGCGCCGTGCTCA
GCGACGAAATCTCCGAAGAGCAGGCTCGCGCCGCGTTGGATGCCTTGCCTTATCTCATCGACAATCGTTACCCGCACAGC
CCACGACTGATCGAATACACATGGCAGCTAAGGCACAACGTCACGTTCTACGACGCCCTTTACGTCGCACTGGCCACCGC
ACTGGATGTCCCGCTGCTCACGGGCGACTCGCGGCTTGCGGCCGCGCCGGGCCTTCCGTGCGAAATCAAACTCGTTCGGT
GA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10547.12 Da        Isoelectric Point: 5.1599

>AT161238 WP_000354046.1 NZ_CP055052:c3850498-3850232 [Shigella dysenteriae]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDEKRIFIRLLECDDPDLFNWLMNHGKPADAELEMMVRLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT161238 NZ_CP071127:71589-71828 [Mycobacterium tuberculosis]
ATGGCTACCATTCAAGTTCGGGATTTGCCCGAAGATGTCGCCGAAACCTATCGACGGCGCGCCACCGCAGCGGGGCAGTC
GCTGCAGACGTATATGCGCACCAAGCTCATCGAAGGGGTGCGGGGCCGAGACAAGGCCGAGGCAATCGAGATCCTGGAAC
AGGCGCTCGCCAGCACTGCCAGCCCAGGCATCAGCCGGGAGACCATCGAGGCATCCCGGCGGGAGCTCAGGGGTGGATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9LFV7

Antitoxin

Source ID Structure
PDB 6B58
PDB 1X6I
PDB 1X6J
PDB 6C12
AlphaFold DB A0A7U9QD57

References