Detailed information of TA system TA161228

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hipBA/HipA-HipB
• Location: 2389337..2390925
• Replicon: chromosome
• Accession: NZ_CP055052
• Organism: Shigella dysenteriae strain SWHEFF_51

Toxin (Protein)

• Gene name: hipA
• Uniprot ID: -
• Locus tag: HUZ69_RS11405
• Protein ID: WP_033815613.1
• Coordinates: 2389337..2390659 (-)
• Length: 441 a.a.

Antitoxin (Protein)

• Gene name: hipB
• Uniprot ID: -
• Locus tag: HUZ69_RS11410
• Protein ID: WP_001613070.1
• Coordinates: 2390659..2390925 (-)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HUZ69_RS11385 (2385220)	2385220..2385489	-	270	Protein_2231	AraC family transcriptional regulator	-
HUZ69_RS11390 (2385758)	2385758..2387161	+	1404	WP_001610308.1	ISNCY family transposase	-
HUZ69_RS11395 (2387192)	2387192..2388109	-	918	WP_001610307.1	S-4TM family putative pore-forming effector	-
HUZ69_RS11400 (2388113)	2388113..2389111	-	999	WP_001610306.1	hypothetical protein	-
HUZ69_RS11405 (2389337)	2389337..2390659	-	1323	WP_033815613.1	type II toxin-antitoxin system serine/threonine protein kinase toxin HipA	Toxin
HUZ69_RS11410 (2390659)	2390659..2390925	-	267	WP_001613070.1	type II toxin-antitoxin system antitoxin HipB	Antitoxin

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	flank	IS/Tn	-	-	2385758..2387161	1403

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA-like, C-terminal (149-401)

Antitoxin

• Cro/C1-type helix-turn-helix domain (18-69)

Sequences

Toxin

Protein

• Length: 441 a.a.
• Molecular weight: 49334.97 Da
• Isoelectric Point: 8.5823

>T161228 WP_033815613.1 NZ_CP055052:c2390659-2389337 [Shigella dysenteriae]
MPKLVTWMNNQRVGELTKLANGAHTFKYAPEWLASRYARPLSLSLPLQRGNITSDAVFNFFDNLLPDSPIVRDRIVKRYH
AKSRQPFDLLSEIGRDSVGAVTLIPEDETVTRPIMAWEKLTEARLEEVLTAYKADIPLGMIREENDFRISVAGAQEKTAL
LRIGNDWCIPKGITPTTHIIKLPIGEIRQPNATLDLSQSVDNEYYCLLLAKELGLNVPDAEIIKAGNVRALAVERFDRRW
NAERTVLLRLPQEDMCQTFGLPSSVKYESDGGPGIARIMAFLMGSSEALKDRYDFMKFQVFQWLIGATDGHAKNFSVFIQ
AGGSYRLTPFYDIISAFPVLGGTGIHISDLKLAMGLNASKGKKTAIDKIYPRHFLATAKVLRFPEVQMHEILSDFARMIP
AALDNVKTSLPTDFPENVVTAVETNVLRLHGRLSREYGIK

Nucleotide

• Length: 1323 bp

>T161228 NZ_CP071102:2290945-2291052 [Staphylococcus aureus]
ATGTTCAATTTATTAATTGACATCATGACTTCAGCTTTAAGCGGCTGTCTTGTTGCGTTTTTTGCACATTGGTTACGAAC
GCGCAACAATAAAAAAGGTGACAAATAA

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 10033.36 Da
• Isoelectric Point: 4.9632

>AT161228 WP_001613070.1 NZ_CP055052:c2390925-2390659 [Shigella dysenteriae]
MMSFQKIYSPTQLANAMKLVRQQNGWTQSELAKKIGIKQATISNFENNPDNTSLTTFFKILQSLELSMTLCDTKNASPES
TEQQDLEW

Nucleotide

• Length: 267 bp

>AT161228 NZ_CP071102:c2291129-2291069 [Staphylococcus aureus]
TACATAATAAATTGAACATCTAAATACACCAAATCCCCTCACTACTGCCATAGTGAGGGGA