Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/UPF0150(antitoxin)
Location 2291271..2291909 Replicon chromosome
Accession NZ_CP055052
Organism Shigella dysenteriae strain SWHEFF_51

Toxin (Protein)


Gene name hicA Uniprot ID S1F9G9
Locus tag HUZ69_RS10995 Protein ID WP_000813794.1
Coordinates 2291271..2291447 (+) Length 59 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag HUZ69_RS11000 Protein ID WP_077778300.1
Coordinates 2291493..2291909 (+) Length 139 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HUZ69_RS10975 (2286890) 2286890..2288065 - 1176 WP_021556777.1 BenE family transporter YdcO -
HUZ69_RS10980 (2288157) 2288157..2288693 + 537 WP_021577428.1 DNA-binding transcriptional regulator SutR -
HUZ69_RS10985 (2288766) 2288766..2290727 + 1962 WP_033815235.1 23S rRNA 5-hydroxycytidine C2501 synthase -
HUZ69_RS10990 (2290819) 2290819..2291049 - 231 WP_000494244.1 YncJ family protein -
HUZ69_RS10995 (2291271) 2291271..2291447 + 177 WP_000813794.1 type II toxin-antitoxin system mRNA interferase toxin HicA Toxin
HUZ69_RS11000 (2291493) 2291493..2291909 + 417 WP_077778300.1 type II toxin-antitoxin system antitoxin HicB Antitoxin
HUZ69_RS11005 (2291988) 2291988..2293394 + 1407 WP_000760655.1 PLP-dependent aminotransferase family protein -
HUZ69_RS11010 (2293639) 2293639..2294784 + 1146 WP_000047424.1 ABC transporter substrate-binding protein -
HUZ69_RS11015 (2294802) 2294802..2295815 + 1014 WP_000220411.1 ABC transporter ATP-binding protein -
HUZ69_RS11020 (2295816) 2295816..2296757 + 942 WP_001251315.1 ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-57)

Antitoxin

Cro/C1-type helix-turn-helix domain

(91-134)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6749.83 Da        Isoelectric Point: 11.2298

>T161227 WP_000813794.1 NZ_CP055052:2291271-2291447 [Shigella dysenteriae]
VKQSEFRRWLESQGVDVANGSNHLKLRFHGRRSVMPRHPCDEIKEPLRKAILKQLGLS

Download         Length: 177 bp

>T161227 NZ_CP071102:2259670-2259936 [Staphylococcus aureus]
ATGAGCAATTACACGGTTAAGATTAAAAATTCGGCGAAGTTAGATTTAAAGAAAATAAAACATCCTTATTTAAAGAAGAC
ATTTATAGAAATTGTTGAGACTTTAAAAAATAATCCTTATAAAATAACACAATCCTTTGAAAAATTAGAACCTAAATATT
TAGAGCGATATTCAAGAAGAATTAACCTTCAGCACAGGGTCGTCTATACCATAGATGATCGAAATAAAGTAGTATTAATA
CTATCGGCATGGTCACATTATGATTAA

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 15261.60 Da        Isoelectric Point: 4.7386

>AT161227 WP_077778300.1 NZ_CP055052:2291493-2291909 [Shigella dysenteriae]
MRYPVTLTPAPEGGYMVSFVDIPEALTQGETVAEAMEAAKDALQTAFDFYFEDNELIPLPSPLNSHDHFIEVPLSVASKV
LLLNAFLQSEITQQELARRIGKPKQEITRLFNLHHATKIDAVQLAAKALGKELSLVMV

Download         Length: 417 bp

>AT161227 NZ_CP071102:2259413-2259670 [Staphylococcus aureus]
ATGATTATCACTAGCCCTACAGAAGCGAGAAAAGATTTTTATCAATTACTAAAAAATGTTAATAATAATCACGAACCAAT
TTATATTAGTGGTAATAATGCCGAAAATAATGCTGTGATTATAGGTTTAGAAGATTGGAAAAGTATACAAGAGACAATGT
ATCTTGTATCTACTGGTACAATGGACAAAGTAAGAGAAAGAGAAAAAGATAATAGTGGTACAACAAATATAGATGATATT
GATTGGGATAATCTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6HPB

Antitoxin

Source ID Structure

References