161225

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1208148..1208766 Replicon chromosome
Accession NZ_CP055052
Organism Shigella dysenteriae strain SWHEFF_51

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag HUZ69_RS05790 Protein ID WP_001291435.1
Coordinates 1208148..1208366 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S1PTH5
Locus tag HUZ69_RS05795 Protein ID WP_000344800.1
Coordinates 1208392..1208766 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HUZ69_RS05755 (1203437) 1203437..1204009 + 573 WP_000779831.1 YbaY family lipoprotein -
HUZ69_RS05760 (1204040) 1204040..1204351 - 312 WP_000409911.1 MGMT family protein -
HUZ69_RS05770 (1204730) 1204730..1205083 + 354 WP_000878140.1 DUF1428 domain-containing protein -
HUZ69_RS05775 (1205125) 1205125..1206675 - 1551 WP_024210825.1 cyclic-guanylate-specific phosphodiesterase PdeB -
HUZ69_RS05780 (1206839) 1206839..1207309 - 471 WP_033814868.1 YlaC family protein -
HUZ69_RS05785 (1207425) 1207425..1207976 - 552 WP_000102564.1 maltose O-acetyltransferase -
HUZ69_RS05790 (1208148) 1208148..1208366 - 219 WP_001291435.1 HHA domain-containing protein Toxin
HUZ69_RS05795 (1208392) 1208392..1208766 - 375 WP_000344800.1 Hha toxicity modulator TomB Antitoxin
HUZ69_RS05800 (1209311) 1209311..1212460 - 3150 WP_001132469.1 efflux RND transporter permease AcrB -
HUZ69_RS05805 (1212483) 1212483..1213676 - 1194 WP_001295324.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T161225 WP_001291435.1 NZ_CP055052:c1208366-1208148 [Shigella dysenteriae]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

>T161225 NZ_CP071102:c167915-167820 [Staphylococcus aureus]
GTGATGCTTATTTTCGTTCACATCATAGCACCAGTCATCAGTGGCTGTGCCATTGCGTTTTTTTCTTATTGGCTAAGTAG
ACGCAATACAAAATAG

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14557.39 Da        Isoelectric Point: 4.7395

>AT161225 WP_000344800.1 NZ_CP055052:c1208766-1208392 [Shigella dysenteriae]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp

>AT161225 NZ_CP071102:167735-167792 [Staphylococcus aureus]
AACGAAAATAAGTATTTACTTATACACCAATCCCCTCACTATTTGCGGTAGTGAGGGG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBQ5

References