Detailed information of TA system TA161219

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-YafN
• Location: 1819..2354
• Replicon: plasmid unnamed1
• Accession: NZ_CP055049
• Organism: Escherichia coli strain SWHEFF_58

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: HUZ70_RS23690
• Protein ID: WP_223051764.1
• Coordinates: 2067..2354 (+)
• Length: 96 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: T1PXV2
• Locus tag: HUZ70_RS23685
• Protein ID: WP_001139206.1
• Coordinates: 1819..2070 (+)
• Length: 84 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HUZ70_RS23680 (HUZ70_23515)	1..873	+	873	WP_179208533.1	incFII family plasmid replication initiator RepA	-
HUZ70_RS23685 (HUZ70_23520)	1819..2070	+	252	WP_001139206.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
HUZ70_RS23690 (HUZ70_23525)	2067..2354	+	288	WP_223051764.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
HUZ70_RS23695	2723..2836	-	114	Protein_3	alkaline phosphatase	-
HUZ70_RS23700 (HUZ70_23535)	2835..3040	+	206	Protein_4	hypothetical protein	-
HUZ70_RS23705 (HUZ70_23540)	3215..6751	-	3537	WP_239606664.1	autotransporter outer membrane beta-barrel domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Conjugative plasmid	-	-	1..129277	129277

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (5-84)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 96 a.a.
• Molecular weight: 11155.25 Da
• Isoelectric Point: 10.5833

>T161219 WP_223051764.1 NZ_CP055049:2067-2354 [Escherichia coli]
MIYTVKFRDDALKEWLRLDKTIQQQFAKKLKKCSENPHIASAKLRGLKDCYKIKLRASGFRLVYQVIDDMLIIAVVAVGK
RERNNVYHLASERMK

Nucleotide

• Length: 288 bp

>T161219 NZ_CP071100:c2119112-2118903 [Staphylococcus aureus]
ATGATACATCAAAATACGATTTACACAGCGGGAATTGAAACAGAAGAACAAGTAAGTCAATTGACAGAACGCATTTCAAA
TATGATAGGTGTTCATCAAGTGAATATTAATATAATAGATGGTCAAGTAACTGTATCGTATGAGACACCAGCAAATTTGA
ATAGTATTGAAAAAGAAATCTATGATGAAGGATACAAAATTGTATTTTAG

Antitoxin

Protein

• Length: 84 a.a.
• Molecular weight: 9171.39 Da
• Isoelectric Point: 4.0927

>AT161219 WP_001139206.1 NZ_CP055049:1819-2070 [Escherichia coli]
MPSIILSDTSASVSELKKNPMATVSAGEGYPVAILNRNQPAFYCVPAELYERMLDALDDQELVKLVTERSSQPLHDVDLD
SYL

Nucleotide

• Length: 252 bp

>AT161219 NZ_CP071100:c2119417-2119124 [Staphylococcus aureus]
ATGACTGAACAAGATAATGCACATCATTCTGAACAAATAAAAACGAATCTTAAATCACGTTTAAATCGAATTGAAGGACA
AGTGAGAGCGATTAATCGCATGATTGAAGAAGATGTCTATTGTGATGATGTCCTTACGCAAATAAGAGCGACACGTTCGG
CGTTAAACAGTGTTGCGATAAAGTTATTAGAACAACATATGAAAAGTTGTATTATGAATAAAGTTAATCAAGGTGCTCAG
GAAGAGGCAATGGAAGAGTTATTAGTGACTTTTCAAAAATTGATTAAAGACTAA

Structures

Antitoxin

• AlphaFold DB: T1PXV2