Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 4122881..4123535 Replicon chromosome
Accession NZ_CP055048
Organism Escherichia coli strain SWHEFF_58

Toxin (Protein)


Gene name cptA Uniprot ID S1PAM6
Locus tag HUZ70_RS19700 Protein ID WP_000244781.1
Coordinates 4123128..4123535 (+) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID A0A0V9GG32
Locus tag HUZ70_RS19695 Protein ID WP_001564007.1
Coordinates 4122881..4123147 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HUZ70_RS19675 (4118969) 4118969..4120402 - 1434 WP_001513393.1 6-phospho-beta-glucosidase BglA -
HUZ70_RS19680 (4120447) 4120447..4120758 + 312 WP_001182951.1 N(4)-acetylcytidine aminohydrolase -
HUZ70_RS19685 (4120922) 4120922..4121581 + 660 WP_000250274.1 hemolysin III family protein -
HUZ70_RS19690 (4121658) 4121658..4122638 - 981 WP_001564008.1 tRNA-modifying protein YgfZ -
HUZ70_RS19695 (4122881) 4122881..4123147 + 267 WP_001564007.1 FAD assembly factor SdhE Antitoxin
HUZ70_RS19700 (4123128) 4123128..4123535 + 408 WP_000244781.1 protein YgfX Toxin
HUZ70_RS19705 (4123575) 4123575..4124096 - 522 WP_001055874.1 flavodoxin FldB -
HUZ70_RS19710 (4124208) 4124208..4125104 + 897 WP_000806638.1 site-specific tyrosine recombinase XerD -
HUZ70_RS19715 (4125129) 4125129..4125839 + 711 WP_000715213.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
HUZ70_RS19720 (4125845) 4125845..4127578 + 1734 WP_000813188.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 16061.99 Da        Isoelectric Point: 11.5202

>T161216 WP_000244781.1 NZ_CP055048:4123128-4123535 [Escherichia coli]
VVLWQSDLRVSWRAQWLSLLIHGLVAAVILLMPWPLSYTPLWMVLLSLVVFDCVRSQRRINARQGEIRLLMDGRLRWQGQ
EWSIVKAPWMIKSGMMLRLRSDSGKRQHLWLAADSMDEAEWRDLRRILLQQETQR

Download         Length: 408 bp

>T161216 NZ_CP071100:1887841-1887936 [Staphylococcus aureus]
GTGATGCTTATTTTCGTTCACATCATAGCACCAGTCATCAGTGGCTGTGCCATTGCGTTTTTTTCTTATTGGCTAAGTAG
ACGCAATACAAAATAG

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10565.15 Da        Isoelectric Point: 5.1599

>AT161216 WP_001564007.1 NZ_CP055048:4122881-4123147 [Escherichia coli]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDEKRIFIRLLECDDPDLFNWMMNHGKPADAELEMMVRLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT161216 NZ_CP071100:c1888021-1887964 [Staphylococcus aureus]
AACGAAAATAAGTATTTACTTATACACCAATCCCCTCACTATTTGCGGTAGTGAGGGG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1PAM6

Antitoxin

Source ID Structure
AlphaFold DB A0A0V9GG32

References