Detailed information of TA system
Overview
TA module
| Type | IV | Classification (family/domain) | yeeUV (cbtA-cbeA)/CbtA-CbeA |
| Location | 2458308..2459143 | Replicon | chromosome |
| Accession | NZ_CP055048 | ||
| Organism | Escherichia coli strain SWHEFF_58 | ||
Toxin (Protein)
| Gene name | yeeV | Uniprot ID | B1LDL9 |
| Locus tag | HUZ70_RS11800 | Protein ID | WP_001094444.1 |
| Coordinates | 2458308..2458685 (-) | Length | 126 a.a. |
Antitoxin (Protein)
| Gene name | yeeU | Uniprot ID | B7LDN9 |
| Locus tag | HUZ70_RS11805 | Protein ID | WP_001285607.1 |
| Coordinates | 2458775..2459143 (-) | Length | 123 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| HUZ70_RS11765 (2453529) | 2453529..2454635 | + | 1107 | WP_001341302.1 | N-acetylneuraminate epimerase | - |
| HUZ70_RS11770 (2454700) | 2454700..2455680 | + | 981 | WP_000991415.1 | sialate O-acetylesterase | - |
| HUZ70_RS11775 (2455688) | 2455688..2456338 | - | 651 | WP_001037966.1 | HNH endonuclease | - |
| HUZ70_RS11780 (2456475) | 2456475..2456618 | + | 144 | Protein_2309 | HNH endonuclease | - |
| HUZ70_RS11785 (2457378) | 2457378..2457521 | - | 144 | Protein_2310 | hypothetical protein | - |
| HUZ70_RS11790 (2457606) | 2457606..2457803 | - | 198 | WP_001327226.1 | DUF957 domain-containing protein | - |
| HUZ70_RS11795 (2457823) | 2457823..2458311 | - | 489 | WP_000761685.1 | DUF5983 family protein | - |
| HUZ70_RS11800 (2458308) | 2458308..2458685 | - | 378 | WP_001094444.1 | TA system toxin CbtA family protein | Toxin |
| HUZ70_RS11805 (2458775) | 2458775..2459143 | - | 369 | WP_001285607.1 | type IV toxin-antitoxin system YeeU family antitoxin | Antitoxin |
| HUZ70_RS11810 (2459223) | 2459223..2459444 | - | 222 | WP_000692350.1 | DUF987 domain-containing protein | - |
| HUZ70_RS11815 (2459531) | 2459531..2460007 | - | 477 | WP_001384029.1 | RadC family protein | - |
| HUZ70_RS11820 (2460022) | 2460022..2460507 | - | 486 | WP_000213722.1 | antirestriction protein | - |
| HUZ70_RS11825 (2460599) | 2460599..2461417 | - | 819 | WP_001175175.1 | DUF932 domain-containing protein | - |
| HUZ70_RS11830 (2461507) | 2461507..2461716 | - | 210 | WP_032150870.1 | DUF905 family protein | - |
| HUZ70_RS11835 (2461746) | 2461746..2462423 | - | 678 | WP_001097301.1 | hypothetical protein | - |
| HUZ70_RS11840 (2462571) | 2462571..2463251 | - | 681 | WP_001282919.1 | WYL domain-containing protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Genomic island | - | fimB | 2450735..2498004 | 47269 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 126 a.a. Molecular weight: 14087.02 Da Isoelectric Point: 7.3523
>T161210 WP_001094444.1 NZ_CP055048:c2458685-2458308 [Escherichia coli]
MNTLPDTHVREASHCQSPVTIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SVCTRSQLINSIDILRARRATGLMARDNYRTVNNITLGKHPGAKQ
MNTLPDTHVREASHCQSPVTIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SVCTRSQLINSIDILRARRATGLMARDNYRTVNNITLGKHPGAKQ
Download Length: 378 bp
>T161210 NZ_CP071097:947480-947734 [Fusobacterium animalis]
ATGTTATTGACTTGGACTGATTTTGCTTGGGAACAATATGAAGAATTACAAGAAAAAGATAAAAGACTTGTAAAAAAGAT
AAATACACTTATTAAGGATATCAAAAGAAATGGTAATGAAGGAATAGGAAAACCAGAACCTTTACAACATGAACTAAGTG
GTTATTGGAGTAGAAGAATTGATGATAAAAATAGATTAGTTTATAAAATATCAGATACTCAAATAACAATAGTTGCTTGT
GCAAATCATTATTAA
ATGTTATTGACTTGGACTGATTTTGCTTGGGAACAATATGAAGAATTACAAGAAAAAGATAAAAGACTTGTAAAAAAGAT
AAATACACTTATTAAGGATATCAAAAGAAATGGTAATGAAGGAATAGGAAAACCAGAACCTTTACAACATGAACTAAGTG
GTTATTGGAGTAGAAGAATTGATGATAAAAATAGATTAGTTTATAAAATATCAGATACTCAAATAACAATAGTTGCTTGT
GCAAATCATTATTAA
Antitoxin
Download Length: 123 a.a. Molecular weight: 13689.53 Da Isoelectric Point: 6.4669
>AT161210 WP_001285607.1 NZ_CP055048:c2459143-2458775 [Escherichia coli]
VSDTLPGTTLPDDNNDRTWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKRLTCEADTLGSCGYVYMAVYPTPETKK
VSDTLPGTTLPDDNNDRTWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKRLTCEADTLGSCGYVYMAVYPTPETKK
Download Length: 369 bp
>AT161210 NZ_CP071097:947223-947480 [Fusobacterium animalis]
ATGATAGCAACAAATTATTCAGAGGTTAGAAATAATTTAAAAACTTATTGTGATAAGGCAACAAAGGACTATGAAACTAT
AATTATTACAAGAAAAAATAATGAAAATGTTGTTTTAATGAGTGAAGAAGAATATAACAATCTTATGGAAAACCTTTATA
TAAGATCAAATCTTAAATATTATCAAAGACTTGTAGAAAGTATAAAAGAAGCTGAAAAGGGTAATGTTAAAGAACATGAT
TTAATAGAGGTGGATTAA
ATGATAGCAACAAATTATTCAGAGGTTAGAAATAATTTAAAAACTTATTGTGATAAGGCAACAAAGGACTATGAAACTAT
AATTATTACAAGAAAAAATAATGAAAATGTTGTTTTAATGAGTGAAGAAGAATATAACAATCTTATGGAAAACCTTTATA
TAAGATCAAATCTTAAATATTATCAAAGACTTGTAGAAAGTATAAAAGAAGCTGAAAAGGGTAATGTTAAAGAACATGAT
TTAATAGAGGTGGATTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | B1LDL9 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A1M0JLU8 |