Detailed information of TA system TA161208

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mosAT/AbiEii-AbiEi
• Location: 2034757..2036446
• Replicon: chromosome
• Accession: NZ_CP055048
• Organism: Escherichia coli strain SWHEFF_58

Toxin (Protein)

• Gene name: mosT
• Uniprot ID: V0Z9M0
• Locus tag: HUZ70_RS09830
• Protein ID: WP_000365809.1
• Coordinates: 2034757..2035677 (-)
• Length: 307 a.a.

Antitoxin (Protein)

• Gene name: mosA
• Uniprot ID: -
• Locus tag: HUZ70_RS09835
• Protein ID: WP_001550661.1
• Coordinates: 2035664..2036446 (-)
• Length: 261 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HUZ70_RS09815 (2030847)	2030847..2031974	-	1128	WP_001550663.1	MFS transporter	-
HUZ70_RS09820 (2032116)	2032116..2033174	-	1059	WP_122987197.1	alpha/beta hydrolase	-
HUZ70_RS09825 (2033439)	2033439..2034323	+	885	WP_001119037.1	LysR family transcriptional regulator	-
HUZ70_RS09830 (2034757)	2034757..2035677	-	921	WP_000365809.1	nucleotidyl transferase AbiEii/AbiGii toxin family protein	Toxin
HUZ70_RS09835 (2035664)	2035664..2036446	-	783	WP_001550661.1	type IV toxin-antitoxin system AbiEi family antitoxin domain-containing protein	Antitoxin
HUZ70_RS09840 (2036762)	2036762..2039971	+	3210	WP_001521910.1	RNA-directed DNA polymerase	-
HUZ70_RS09845 (2040318)	2040318..2040788	+	471	WP_000201185.1	hypothetical protein	-
HUZ70_RS09850 (2040785)	2040785..2040887	+	103	Protein_1933	helix-turn-helix domain-containing protein	-
HUZ70_RS09855 (2040979)	2040979..2041137	+	159	Protein_1934	integrase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Nucleotidyl transferase AbiEii toxin, Type IV TA system (14-261)

Antitoxin

• Transcriptional regulator, AbiEi 3 antitoxin, Type IV TA system (95-247)

Sequences

Toxin

Protein

• Length: 307 a.a.
• Molecular weight: 34571.01 Da
• Isoelectric Point: 7.2649

>T161208 WP_000365809.1 NZ_CP055048:c2035677-2034757 [Escherichia coli]
MDLRDSYARQVKLLMAALPYVAKESCFALKGGTAINLFVQDFPRLSVDIDLAYKSFADRDTDLAAINDALKRITASLNGR
PGITAIRQENKADEKRIIVNTADAKIKIEVSPVWRGLLLPPAEMPVCERVEMEYGFTTMSVVSLADLYGGKICAALDRQH
PRDLFDVLNMLEKPGLMREIFDGFLCYLAGHPRPIAELLAPNWDTERIATLYAQEFSGMTQQETSLESLLSVTTLLPQAL
KSHLTDLDREFLLSFKQNSPDWSRYRYPEIQHLPAIRWKQRNLAVLKDKNPAKYVAAVNKLERVLA

Nucleotide

• Length: 921 bp

>T161208 NZ_CP071096:c2211743-2211486 [Fusobacterium polymorphum]
ATGTTATTAACTTGGACCGATTTTGCATGGGAACAATATGAAGAGTTACAAGAAAAGGATAAAAGGCTTATAAAGAAGAT
AAATATACTTATTAAGGATATAAAAAGAAATGGAAATGAAGGAATAGGTAAACCAGAGCCTTTACAACATGAGTTAAGTG
GCTATTGGAGTAGAAGAATTGATGATAAAAATAGATTAGTCTATAAAGTATCAGATAATCAAATAACAATAGTTGCTTGT
GCGAATCATTATAAGTAA

Antitoxin

Protein

• Length: 261 a.a.
• Molecular weight: 29191.43 Da
• Isoelectric Point: 8.9059

>AT161208 WP_001550661.1 NZ_CP055048:c2036446-2035664 [Escherichia coli]
MPNYLNWLMQHTLPGQVLLQSWLTRNGIDRKLSYLYVKNGWLRRIAHGVYCRTGREPDWVDAVYCLQSQWEKPVRVAGLT
SLALQGHAHYTEQGKPQVWLALPAYVKLPGWFSAFEQSATFVTLYTSGLTADVTPFTTELKIGDRQLAGSVPELAAYEIA
CGVPSLISFEHADALFQGLNLLSPRKLQALLRASHSVKTNRVMLYLARRNGHPYFQYIDQSGIETGTGKRQIIPGGWLEP
DYQITVPRAFKPEGVEDGSA

Nucleotide

• Length: 783 bp

>AT161208 NZ_CP071096:c2212000-2211743 [Fusobacterium polymorphum]
ATGATAGCAACTAATTATTCTGAAGTTAGAAATAATTTAAAAGCTTATTGTGATAAGGCAACTAAAGACTATGAAACTAT
TATTATTACAAGAAAAAATAATGAAAATGTTGTCTTAATGAGTGAAGAAGAATACAATAATCTTATGGAAAACCTTTATA
TAAGATCAAATCTTAAATATTATCAAAAACTTGTAGAAAGTATAAAAGAAGTTGAAAAAGGTAATGTTAAAGAACATGAT
TTAATAGAGGTGGATTAA

Structures

Toxin

• AlphaFold DB: V0Z9M0