Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1795445..1796063 Replicon chromosome
Accession NZ_CP055048
Organism Escherichia coli strain SWHEFF_58

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag HUZ70_RS08625 Protein ID WP_001291435.1
Coordinates 1795845..1796063 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S1PTH5
Locus tag HUZ70_RS08620 Protein ID WP_000344800.1
Coordinates 1795445..1795819 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HUZ70_RS08610 (1790534) 1790534..1791727 + 1194 WP_001295833.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
HUZ70_RS08615 (1791750) 1791750..1794899 + 3150 WP_001132480.1 efflux RND transporter permease AcrB -
HUZ70_RS08620 (1795445) 1795445..1795819 + 375 WP_000344800.1 Hha toxicity modulator TomB Antitoxin
HUZ70_RS08625 (1795845) 1795845..1796063 + 219 WP_001291435.1 HHA domain-containing protein Toxin
HUZ70_RS08630 (1796235) 1796235..1796786 + 552 WP_000102564.1 maltose O-acetyltransferase -
HUZ70_RS08635 (1796902) 1796902..1797372 + 471 WP_000136192.1 YlaC family protein -
HUZ70_RS08640 (1797536) 1797536..1799086 + 1551 WP_001366446.1 cyclic-guanylate-specific phosphodiesterase PdeB -
HUZ70_RS08645 (1799128) 1799128..1799481 - 354 WP_001550741.1 DUF1428 family protein -
HUZ70_RS08655 (1799860) 1799860..1800171 + 312 WP_000409911.1 MGMT family protein -
HUZ70_RS08660 (1800202) 1800202..1800774 - 573 WP_000779831.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T161207 WP_001291435.1 NZ_CP055048:1795845-1796063 [Escherichia coli]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

>T161207 NZ_CP071096:11736-11867 [Fusobacterium polymorphum]
TTGTTAGGAAATTTAAAAGATTATTGGAGATATAGAATAGGTGATTATAGATTAATTACTAAAATTGATGATGGAAAACT
ATTAATTATTGCATTAGAACTTAAACATAGGAAAGAAGCCTATAAATACTAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14557.39 Da        Isoelectric Point: 4.7395

>AT161207 WP_000344800.1 NZ_CP055048:1795445-1795819 [Escherichia coli]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp

>AT161207 NZ_CP071096:11376-11600 [Fusobacterium polymorphum]
ATGTCAAATATTACATTAAGGTTAACAGATGAAGAAAGAGAAATACTGAACAATGTAGCTCATTTATATGCTGACAAATT
ATCAACAGCAATAAAAACAATATTATTTGAAAAAATAGAAGAAGATTATAATTTAAAGATAGTTAAAGATTTTGAAAAAA
GAGAAAAAGAAAATAAGGTGGAATTAGTTAGTTTATCTGACTTTAGAAAAAAGTTAGGTGTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBQ5

References