Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 1135581..1136365 Replicon chromosome
Accession NZ_CP055048
Organism Escherichia coli strain SWHEFF_58

Toxin (Protein)


Gene name TacT2 Uniprot ID V0T0H9
Locus tag HUZ70_RS05645 Protein ID WP_000613626.1
Coordinates 1135871..1136365 (+) Length 165 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID L4JCW6
Locus tag HUZ70_RS05640 Protein ID WP_001110447.1
Coordinates 1135581..1135874 (+) Length 98 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HUZ70_RS05630 (1130731) 1130731..1131690 - 960 WP_000846342.1 23S rRNA pseudouridine(955/2504/2580) synthase RluC -
HUZ70_RS05635 (1132263) 1132263..1135448 + 3186 WP_001550951.1 ribonuclease E -
HUZ70_RS05640 (1135581) 1135581..1135874 + 294 WP_001110447.1 DUF1778 domain-containing protein Antitoxin
HUZ70_RS05645 (1135871) 1135871..1136365 + 495 WP_000613626.1 GNAT family N-acetyltransferase Toxin
HUZ70_RS05650 (1136460) 1136460..1137413 - 954 WP_001212768.1 flagellar hook-associated protein FlgL -
HUZ70_RS05655 (1137425) 1137425..1139068 - 1644 WP_000096478.1 flagellar hook-associated protein FlgK -
HUZ70_RS05660 (1139134) 1139134..1140075 - 942 WP_137503916.1 flagellar assembly peptidoglycan hydrolase FlgJ -
HUZ70_RS05665 (1140075) 1140075..1141172 - 1098 WP_001441925.1 flagellar basal body P-ring protein FlgI -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(81-144)

Antitoxin

(14-88)


Sequences


Toxin        


Download         Length: 165 a.a.        Molecular weight: 18084.00 Da        Isoelectric Point: 8.2617

>T161205 WP_000613626.1 NZ_CP055048:1135871-1136365 [Escherichia coli]
MIQAPEPLMARHQFTSFCSGVETMDNWLKQRALKNQLAGASRTFVSCDTYSNVLAYYSLASSAVETYVATGRFRRNMPEP
IPVVVLGRLAIDKSLQGQGIGRAMVRDAGLRVLQAAEVIGIRGMLVHALSDQAREFYLRVGFEPSPVDSMILMATLADLQ
ECLK

Download         Length: 495 bp

>T161205 NZ_CP071094:582037-582165 [Fusobacterium polymorphum]
ATGTATGAAATTAAGACCACTACTAAATTTGAAAAAGACTTAAAATTAATGAAAAAAAGAGGATATAATTTAAAATTATT
AAAAGAGGTAATTAATATGTTATCTAAAGGAGCTAAAAGCAGATTATAA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11109.69 Da        Isoelectric Point: 10.5423

>AT161205 WP_001110447.1 NZ_CP055048:1135581-1135874 [Escherichia coli]
MPAANNIPTRRESLNLRIKPAERDLIDRAAKARGKNRTEFVLEAARAAAEEALIEQRIFRIDSDDYQLFLNRLDQPPAPN
AALRKTMQTPAPWEQKK

Download         Length: 294 bp

>AT161205 NZ_CP071094:581838-582035 [Fusobacterium polymorphum]
TTGGGACTTAATATATCAGTTGCAATAAATTTATTTCTAAAAAAATGTATAAATGAAAATGGGATGCCATTTGATTTAAA
AATTCCAAATAAAAAAACAATAGAAGCAATGGAAGGAACTAACAAAATATTAAATGGAGATATAGAAAGAAAGTCATATA
AAAATGCTGATGAGTTATTTGAAGATTTAGGTGTGTAA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB V0T0H9


Antitoxin

Source ID Structure
AlphaFold DB L4JCW6

References