Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 116038..116870 Replicon chromosome
Accession NZ_CP055048
Organism Escherichia coli strain SWHEFF_58

Toxin (Protein)


Gene name yeeV Uniprot ID A0A1L4HFA4
Locus tag HUZ70_RS00570 Protein ID WP_032163901.1
Coordinates 116038..116412 (-) Length 125 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID S1NM52
Locus tag HUZ70_RS00575 Protein ID WP_001295723.1
Coordinates 116502..116870 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HUZ70_RS00530 (111434) 111434..112600 + 1167 WP_042031746.1 serine-type D-Ala-D-Ala carboxypeptidase DacD -
HUZ70_RS00535 (112719) 112719..113192 + 474 WP_001105415.1 DNA gyrase inhibitor SbmC -
HUZ70_RS00540 (113390) 113390..114448 + 1059 WP_001200891.1 FUSC family protein -
HUZ70_RS00545 (114620) 114620..114949 + 330 WP_000450409.1 DUF496 family protein -
HUZ70_RS00550 (115050) 115050..115184 - 135 WP_001297944.1 EutP/PduV family microcompartment system protein -
HUZ70_RS00555 (115304) 115304..115432 + 129 Protein_110 transposase domain-containing protein -
HUZ70_RS00560 (115721) 115721..115801 - 81 Protein_111 hypothetical protein -
HUZ70_RS00565 (115847) 115847..116041 - 195 WP_000988600.1 DUF5983 family protein -
HUZ70_RS00570 (116038) 116038..116412 - 375 WP_032163901.1 TA system toxin CbtA family protein Toxin
HUZ70_RS00575 (116502) 116502..116870 - 369 WP_001295723.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
HUZ70_RS00580 (117033) 117033..117254 - 222 WP_000692345.1 DUF987 domain-containing protein -
HUZ70_RS00585 (117317) 117317..117793 - 477 WP_001186726.1 RadC family protein -
HUZ70_RS00590 (117809) 117809..118294 - 486 WP_000849582.1 antirestriction protein -
HUZ70_RS00595 (118349) 118349..119168 - 820 Protein_118 DUF932 domain-containing protein -
HUZ70_RS00600 (119268) 119268..119501 - 234 WP_001119729.1 DUF905 family protein -
HUZ70_RS00605 (119580) 119580..120035 - 456 WP_000581504.1 IrmA family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 125 a.a.        Molecular weight: 13919.89 Da        Isoelectric Point: 7.7760

>T161194 WP_032163901.1 NZ_CP055048:c116412-116038 [Escherichia coli]
MKTLPDTHVREASSCPSPVTIWQTLLSRLLGQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKYPEAK

Download         Length: 375 bp

>T161194 NZ_CP071086:c2881671-2880349 [Klebsiella pneumoniae]
ATGGCGACGCTTACCACCTGGATGAACAATGTGCGCGTGGGAACCTTAACCCGCCAGGCTAACGGGGCGCACAGTTTTCG
CTATGACGAAGAGTGGCTGCGCAGCCCGCGCGCCAGACCGCTCTCCCTCTCACTGCCGCTGCAGTATGGCAATATCACTG
CCGACGCGGTGTATCACTATTTTGATAACCTGCTGCCCGACAGCCCGCAGGTCCGCGACCGGATCGTCAGGCGCTATCAG
GCGCGCTCGAAGCAGCCGTTCGATCTGCTGGCCGAAGTCGGGCGGGATAGCGTAGGGGCGGTGACCCTCCTGCCGCCGGG
GGAAGAGGCGCACCTGGAAGGATTACGCTGGCAGACGCTGGACGAGGCGCAGCTCACCGCTTTGCTGACCGCTTACCAGT
CGGATATCCCCCTCGGGATGATTACCAGCCAGGACGATTTCCGTATCTCGGTGGCCGGCGCCCAGGAGAAAACGGCGCTG
CTGCGGATGGGCGAGCAGTGGTGTATTCCGCAGGGCGCCACGCCGACCACGCATATCATTAAGCTGCCCATCGGCGAGAT
CAAGCAGCCCAATGCGACGCTGGATCTGCGTGAAAGCGTGGATAATGAGTATCTGTGCCTGGCGCTGGCCAGAGAACTGG
GCCTGGCGGTGCCGGAAGCGGAGATCATCACCACCCCGCGGATCCGCGCCCTGGCGGTAACCCGCTTCGACCGGCGCTGG
GCGCAGGAGGGACGGGTGCTGCTGCGTCTGCCGCAGGAGGATCTGTGTCAGGCTTTTGGTCTTCCTTCAGCGATGAAATA
TGAGTCTGACGGCGGGCCGGGTATCGCCGCGATCATGACCTTTCTGCTGGGCTCGAGTGAAGCGCTGAAAGATCGCTATG
ACTTTATGAAGTTCATGGTCTTCCAGTGGCTGACGGGGGCGACGGACGGTCACGCAAAAAACTTCTCAATTTACCTGTTG
CCCGGCGGCAGCTACCGCTTAACACCGTTCTACGACATTATTTCGGCGTTTCCGGTGCTGGGCGGCACGGGACTGCATCT
GCGCGATCTGAAGCTGTCGATGGGGCTCAATGCCACAAAAGGGCGTAAAACAGAGATTAACGCCATCTATCCGCGTCATT
TTCTGGCGACGGCCAAAGCGGTGAACTTTCCCCTGGAGCAGATGCTGGCGATCCTCCAGGAGTTTGCCGGGCATGTGCCG
CAGGCAATCGAAAGCGCTCGCCGGACGCTGCCGGCGGACTTTTCCAGCCACGTCTGGCAGGCCATTACAGAGAACATGCT
GAAGCTGCACGCCCGCCTGCAGCAAGGGCTGCAGGCGCTATAG

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13592.40 Da        Isoelectric Point: 6.6255

>AT161194 WP_001295723.1 NZ_CP055048:c116870-116502 [Escherichia coli]
VSDTLSGTTHPDDNDDHPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGRFRDADAYPLDQAFPLLMKQLKLMLTSG
ELNPRHQHTVTLYAKGLTCEADTLGSCGYVYLAVYPTPETKK

Download         Length: 369 bp

>AT161194 NZ_CP071086:c2881937-2881671 [Klebsiella pneumoniae]
ATGAATTCCCCGCAGATATACAGTCCCGTGCAGCTGGCCAATTACCTGAAGCTGCTGCGCCAGCAGAACCACTGGACCCA
GGATGCGCTGGCCAGGCGGATCGGCATTAAGCAGGCCACGCTGTCCAATTTTGAAAATCACCCCGACAAAACCACCTTAA
CCACGCTGTTTAAGATCCTCCAGTCGCTGGGGGTGGTGATGACGCTGAACGCCAAAGCTGCTGAGACGGCGCCGGCTCCC
GATAACAACACGGACCTTGACTGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1L4HFA4

Antitoxin

Source ID Structure
AlphaFold DB S1NM52

References