Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE-HTH_XRE
Location 3152296..3153001 Replicon chromosome
Accession NZ_CP055037
Organism Shigella flexneri strain SWHEFF_60

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag HUZ72_RS15365 Protein ID WP_222683096.1
Coordinates 3152296..3152682 (+) Length 129 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag HUZ72_RS15370 Protein ID WP_001280945.1
Coordinates 3152672..3153001 (+) Length 110 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HUZ72_RS15345 (3148300) 3148300..3148926 + 627 WP_001295292.1 glutathione S-transferase GstB -
HUZ72_RS15350 (3148923) 3148923..3150038 - 1116 Protein_3018 aldose sugar dehydrogenase YliI -
HUZ72_RS15355 (3150149) 3150149..3150532 - 384 WP_000497137.1 biofilm formation regulator BssR -
HUZ72_RS15360 (3150745) 3150745..3152070 + 1326 WP_000049367.1 30S ribosomal protein S12 methylthiotransferase RimO -
HUZ72_RS15365 (3152296) 3152296..3152682 + 387 WP_222683096.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
HUZ72_RS15370 (3152672) 3152672..3153001 + 330 WP_001280945.1 DNA-binding transcriptional regulator Antitoxin
HUZ72_RS15375 (3153071) 3153071..3154399 - 1329 WP_000086877.1 GGDEF domain-containing protein -
HUZ72_RS15380 (3154407) 3154407..3156755 - 2349 WP_001338403.1 EAL domain-containing protein -
HUZ72_RS15385 (3156933) 3156933..3157844 - 912 WP_001236042.1 glutathione ABC transporter permease GsiD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-2

(1-124)

Antitoxin

Cro/C1-type helix-turn-helix domain

(53-94)


Sequences

Toxin        


Download         Length: 129 a.a.        Molecular weight: 14365.51 Da        Isoelectric Point: 9.7108

>T161154 WP_222683096.1 NZ_CP055037:3152296-3152682 [Shigella flexneri]
MGVYKARRFSQSTKKLGIHDKVLMAAAEEVMQGIWEADLGSGVIKKRLPLQQGKSGGARTIIFFKSANHVFFYDGWSKSG
LSSKETKEIEDDELAAYKKMANAFLAFSNKQIEDLIETGFLIEVKNER

Download         Length: 387 bp

>T161154 NZ_CP071072:7741-8157 [Citrobacter sedlakii]
ATGAAGAAAACCTGGATGCTCGACACCAACATCTGCTCGTTCATCATGCGCGAGCAGCCGGCAGCGGTGCTGAAGCGCCT
GGAGCAGGCGGTGCTGCGCGGTGATCGCATTGTGGTCTCGGCCGTGACGTATGCCGAGATGCGCTTCGGCGCCACCGGCC
CGAAGGCCTCGCCGCGCCATATTCAGCTGGTCGACGCGTTCTGCGCGCGCCTCGATGCCGTCCTGCCCTGGGACCGCGCC
GCGGTGGACGCCACGACGGACATCCGGGTGGCGCTGCGCCTAGCCGGGACGCCGATCGGCCCGAATGACACGGCCATTGC
CGGGCACGCCATCGCGGCGGGCGCCATCCTGGTGACGAACAATGTGAGAGAGTTTGCGCGGGTCCCGGGCCTGGTGCTGG
AAGACTGGGTGAAATAA

Antitoxin


Download         Length: 110 a.a.        Molecular weight: 11982.08 Da        Isoelectric Point: 10.0101

>AT161154 WP_001280945.1 NZ_CP055037:3152672-3153001 [Shigella flexneri]
MSDKLQMMLEDAKELNALGLMSDSEVDAIAVMVKAREVSARIAKVKSMTGEEIKAIRTRYGMSQSVLAHTMGMSKESVSK
WERNEIKPSGPALRILNTLAIKGPEVFAK

Download         Length: 330 bp

>AT161154 NZ_CP071072:7514-7744 [Citrobacter sedlakii]
ATGCGCACAGTTTCGATATTTAAAAACGGCAATAACCGCGCCATCCGTCTGCCCCGGGACCTGGATTTTGATGGCGTCAG
CGAGCTGGAGATCGTCCGGGAAGGGGACAGCATCATTCTGCGTCCCGTCCGGCCGACCTGGGGCTCGTTCGCGCAGCTGG
ACAGGGCCGATCCGGACTTTATGGCGGAGCGTGAGGATGTGGTCAGCGATGAAGGACGCTTTGAGCCATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References