Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/UPF0150(antitoxin)
Location 2486343..2486981 Replicon chromosome
Accession NZ_CP055037
Organism Shigella flexneri strain SWHEFF_60

Toxin (Protein)


Gene name hicA Uniprot ID S1F9G9
Locus tag HUZ72_RS12005 Protein ID WP_000813794.1
Coordinates 2486805..2486981 (-) Length 59 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag HUZ72_RS12000 Protein ID WP_001270286.1
Coordinates 2486343..2486759 (-) Length 139 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HUZ72_RS11980 (2481495) 2481495..2482436 - 942 WP_001251313.1 ABC transporter permease -
HUZ72_RS11985 (2482437) 2482437..2483450 - 1014 WP_239637368.1 ABC transporter ATP-binding protein -
HUZ72_RS11990 (2483468) 2483468..2484613 - 1146 WP_000047421.1 ABC transporter substrate-binding protein -
HUZ72_RS11995 (2484858) 2484858..2486264 - 1407 WP_000760626.1 PLP-dependent aminotransferase family protein -
HUZ72_RS12000 (2486343) 2486343..2486759 - 417 WP_001270286.1 type II toxin-antitoxin system antitoxin HicB Antitoxin
HUZ72_RS12005 (2486805) 2486805..2486981 - 177 WP_000813794.1 type II toxin-antitoxin system mRNA interferase toxin HicA Toxin
HUZ72_RS12010 (2487203) 2487203..2487433 + 231 WP_000494244.1 YncJ family protein -
HUZ72_RS12015 (2487525) 2487525..2489486 - 1962 WP_001301045.1 23S rRNA 5-hydroxycytidine C2501 synthase -
HUZ72_RS12020 (2489559) 2489559..2490095 - 537 WP_000429155.1 DNA-binding transcriptional regulator SutR -
HUZ72_RS12025 (2490187) 2490187..2491362 + 1176 WP_001236261.1 BenE family transporter YdcO -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-57)

Antitoxin

Cro/C1-type helix-turn-helix domain

(91-134)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6749.83 Da        Isoelectric Point: 11.2298

>T161153 WP_000813794.1 NZ_CP055037:c2486981-2486805 [Shigella flexneri]
VKQSEFRRWLESQGVDVANGSNHLKLRFHGRRSVMPRHPCDEIKEPLRKAILKQLGLS

Download         Length: 177 bp

>T161153 NZ_CP071071:c14256-13906 [Citrobacter sedlakii]
ATGTGGGTCATCGAGACAACTGACACCTTTGATGAGTGGTTCGATGCACTGGATGATACCGATAGAGCCAACGTGCTGGC
TTCGATGATGGTGCTGCGAGATAGAGGTCCCATGCTGTCGAGACCATACGCGGATACTGTTAACGGTTCATCCTACAGCA
ACATGAAAGAGCTGCGGGTCCAAAGCAAAGGAGATCCTATCAGGGCATTCTTTGCGTTCGATCCAAAGCGTAAGGGGATT
CTTCTCTGCGCCGGTAACAAGACCGGGGACGAGAAAAGGTTTTATGAAGTAATGATCCCAATTGCAGACCGCGAGTTTGC
GGCGCACTTGGATAAATTGAAGAAGGAGTGA

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 15246.63 Da        Isoelectric Point: 4.7386

>AT161153 WP_001270286.1 NZ_CP055037:c2486759-2486343 [Shigella flexneri]
MRYPVTLTPAPEGGYMVSFVDIPEALTQGETVAEAMEAAKDALLTAFDFYFEDNELIPLPSPLNSHDHFIEVPLSVASKV
LLLNAFLQSEITQQELARRIGKPKQEITRLFNLHHATKIDAVQLAAKALGKELSLVMV

Download         Length: 417 bp

>AT161153 NZ_CP071071:c13901-13599 [Citrobacter sedlakii]
ATGGCAAGAACTCTTGACCAAATGCTGGCAACAGAAAAGCCTGAGGTTGTTGCCAAAGCACAGAAAGCGGCCACTGAGAT
GTTACTGAACATCCACTTGGCAGAGCTTCGTGATCGCATGAACCTTACCCAGGGGGAAATTGCTGCATCTCTGGGTGTGA
GACAGCCGACAGTCTCCGAGATGGAAAAACCTGGACGAGATCTCAAGCTGTCGTCCATTAAGCGGTACGTTGAGGCCTCC
GGTGGCAAGCTACGCCTCGATGTTGAACTTCCGGACGGCACCCACTACGGCTTTGCCGTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6HPB

Antitoxin

Source ID Structure

References