Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) ataRT/ElaA-DUF1778
Location 209161..209912 Replicon plasmid unnamed1
Accession NZ_CP055034
Organism Klebsiella pneumoniae strain SWHEFF_62

Toxin (Protein)


Gene name ataT Uniprot ID -
Locus tag HUZ73_RS26700 Protein ID WP_072046196.1
Coordinates 209161..209643 (-) Length 161 a.a.

Antitoxin (Protein)


Gene name ataR Uniprot ID A0A071LPN3
Locus tag HUZ73_RS26705 Protein ID WP_004902250.1
Coordinates 209634..209912 (-) Length 93 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HUZ73_RS26685 (HUZ73_26590) 204469..205992 - 1524 WP_239594580.1 EAL domain-containing protein -
HUZ73_RS26690 (HUZ73_26595) 206372..207340 + 969 WP_239594581.1 IS5-like element IS903B family transposase -
HUZ73_RS26695 (HUZ73_26600) 207586..208125 - 540 WP_135720529.1 hypothetical protein -
HUZ73_RS26700 (HUZ73_26605) 209161..209643 - 483 WP_072046196.1 GNAT family N-acetyltransferase Toxin
HUZ73_RS26705 (HUZ73_26610) 209634..209912 - 279 WP_004902250.1 DUF1778 domain-containing protein Antitoxin
HUZ73_RS26710 (HUZ73_26615) 210031..210243 - 213 WP_004902255.1 hypothetical protein -
HUZ73_RS26715 (HUZ73_26620) 210351..210692 - 342 WP_135720527.1 hypothetical protein -
HUZ73_RS26940 211278..211424 - 147 Protein_228 DUF2235 domain-containing protein -
HUZ73_RS26725 211459..211569 + 111 Protein_229 glutathione ABC transporter permease GsiC -
HUZ73_RS26730 (HUZ73_26630) 211653..213323 - 1671 WP_032413257.1 AMP-binding protein -
HUZ73_RS26735 (HUZ73_26635) 213304..214569 - 1266 WP_048281137.1 MSMEG_0569 family flavin-dependent oxidoreductase -
HUZ73_RS26740 (HUZ73_26640) 214587..214877 - 291 WP_032413253.1 MSMEG_0570 family nitrogen starvation response protein -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid qnrS1 / blaLAP-2 / aph(6)-Id / floR / sul2 / aph(4)-Ia / aac(3)-IVa / aph(3')-Ia / aadA2 / dfrA12 / tet(A) iutA / iucD / iucC / iucB / iucA / pla 1..242129 242129


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(45-146)

Antitoxin

(10-86)


Sequences


Toxin        


Download         Length: 161 a.a.        Molecular weight: 17678.45 Da        Isoelectric Point: 8.9130

>T161136 WP_072046196.1 NZ_CP055034:c209643-209161 [Klebsiella pneumoniae]
MGMRAPESLTAEHNIAEFCCQEPALNEWLKKKALRNHSTGISRVYVVCAENTNRVIGYYCLSSGSVHRNTVPGAYRRNAP
DVIPVIVLGRLAIDQAWSGNGLGAALLKDAIYRTQNIAFQVGVRALAVHALNEEVKCFYTRFGFEPSIVNTLTLLFPIKV

Download         Length: 483 bp

>T161136 NZ_CP071063:469519-469803 [Enterobacter mori]
ATGACTTATGAACTGGCGTTTGATCCGAGGGCGTTAAAGGAGTGGAGCAAGCTGGGGGAGACTGTAAAAGACCATTTTAA
GAAGAAACTTGCGGATGTGTTGGTGAACCCAAGGGTCGAATCGGCCCGCCTGCATGGTCTACCGGATTGCTACAAAATAA
AACTCAGATCGCAGGGTTATCGTTTGGTCTATCAGGTTCAGGACAATGTTGTAACGGTATTTGTTATCGCTATCGGTAAG
AGAGAGAAATCAGCCGTTTATCATGATGCAAACAAACGGCTTTAG

Antitoxin


Download         Length: 93 a.a.        Molecular weight: 10704.23 Da        Isoelectric Point: 4.5271

>AT161136 WP_004902250.1 NZ_CP055034:c209912-209634 [Klebsiella pneumoniae]
MKPDVREAPINIRAKTSQRDLIDMAASLVSKSRTDFMLEVACREAQDILLDQRLFLLNDNQFEAFIEELDAPITPERQAR
IDNLMNRKSPWE

Download         Length: 279 bp

>AT161136 NZ_CP071063:469287-469529 [Enterobacter mori]
ATGGCCACGCTTAACGTCCGTCTGGATGACAAACTCAAAAACGAGGCTTACGCCGTGCTGGAAAAACTCAACATCACCCC
TACGGAAGCGGTACGATTACTGTTTCAGTACGTAGCTGAAACAGGACGCATGCCCGTGAAAACGGTCACGATTAGTGACA
GCGAAGATGCGCTGATACAGACGGTCCGGGAGCGGCTGGCTAATCCGCAAAAGGGAATTAAGGTTAGTCTGGATGACTTA
TGA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure


Antitoxin

Source ID Structure
AlphaFold DB A0A071LPN3

References