Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4669935..4670451 Replicon chromosome
Accession NZ_CP055033
Organism Klebsiella pneumoniae strain SWHEFF_62

Toxin (Protein)


Gene name relE Uniprot ID J2XDK6
Locus tag HUZ73_RS22950 Protein ID WP_002886902.1
Coordinates 4669935..4670219 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag HUZ73_RS22955 Protein ID WP_002886901.1
Coordinates 4670209..4670451 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HUZ73_RS22925 (4665351) 4665351..4665614 - 264 WP_014908078.1 PTS sugar transporter subunit IIB -
HUZ73_RS22930 (4665744) 4665744..4665917 + 174 WP_032410138.1 hypothetical protein -
HUZ73_RS22935 (4665920) 4665920..4666663 + 744 WP_021441079.1 MurR/RpiR family transcriptional regulator -
HUZ73_RS22940 (4667020) 4667020..4669158 + 2139 WP_004186701.1 anaerobic ribonucleoside-triphosphate reductase -
HUZ73_RS22945 (4669467) 4669467..4669931 + 465 WP_023302390.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
HUZ73_RS22950 (4669935) 4669935..4670219 - 285 WP_002886902.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
HUZ73_RS22955 (4670209) 4670209..4670451 - 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
HUZ73_RS22960 (4670529) 4670529..4672439 - 1911 WP_009486549.1 PRD domain-containing protein -
HUZ73_RS22965 (4672462) 4672462..4673616 - 1155 WP_023302389.1 lactonase family protein -
HUZ73_RS22970 (4673683) 4673683..4674423 - 741 WP_002886899.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-82)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11125.95 Da        Isoelectric Point: 10.3787

>T161131 WP_002886902.1 NZ_CP055033:c4670219-4669935 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESARLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

>T161131 NZ_CP071062:c2293281-2293201 [Dickeya solani]
AATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTAGACCGGGCACAGGAATCGTGTTCGGTCTTTTTT
T

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT161131 WP_002886901.1 NZ_CP055033:c4670451-4670209 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp

>AT161131 NZ_CP071062:2293199-2293281 [Dickeya solani]
ATAAAAAAAGACCGAACACGATTCCTGTGCCCGGTCTAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGC
ATT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GMH2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References