Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 785081..785738 Replicon chromosome
Accession NZ_CP055033
Organism Klebsiella pneumoniae strain SWHEFF_62

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag HUZ73_RS03905 Protein ID WP_002916310.1
Coordinates 785328..785738 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag HUZ73_RS03900 Protein ID WP_002916312.1
Coordinates 785081..785347 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HUZ73_RS03875 (780237) 780237..781670 - 1434 WP_002916322.1 6-phospho-beta-glucosidase BglA -
HUZ73_RS03880 (781789) 781789..782517 - 729 WP_002916321.1 MurR/RpiR family transcriptional regulator -
HUZ73_RS03885 (782567) 782567..782878 + 312 WP_004144734.1 N(4)-acetylcytidine aminohydrolase -
HUZ73_RS03890 (783042) 783042..783701 + 660 WP_002916317.1 hemolysin III family protein -
HUZ73_RS03895 (783852) 783852..784835 - 984 WP_004185555.1 tRNA-modifying protein YgfZ -
HUZ73_RS03900 (785081) 785081..785347 + 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
HUZ73_RS03905 (785328) 785328..785738 + 411 WP_002916310.1 protein YgfX Toxin
HUZ73_RS03910 (785745) 785745..786266 - 522 WP_004144730.1 flavodoxin FldB -
HUZ73_RS03915 (786367) 786367..787263 + 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
HUZ73_RS03920 (787286) 787286..787999 + 714 WP_004185548.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
HUZ73_RS03925 (788005) 788005..789738 + 1734 WP_004149758.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T161118 WP_002916310.1 NZ_CP055033:785328-785738 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

>T161118 NZ_CP071043:513544-513894 [Bacillus subtilis]
TTGATTGTGAAACGCGGCGATGTTTATTTTGCTGATTTATCTCCTGTTGTTGGCTCAGAGCAAGGCGGGGTGCGCCCGGT
TTTAGTGATCCAAAATGACATCGGAAATCGCTTCAGCCCAACTGCTATTGTTGCAGCCATAACAGCACAAATACAGAAAG
CGAAATTACCAACCCACGTCGAAATCGATGCAAAACGCTACGGTTTTGAAAGAGATTCCGTTATTTTGCTGGAGCAAATT
CGGACGATTGACAAGCAAAGGTTAACGGATAAGATTACTCATCTGGATGATGAAATGATGGATAAGGTTGATGAAGCCTT
ACAAATCAGTTTGGCACTCATTGATTTTTAG

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT161118 WP_002916312.1 NZ_CP055033:785081-785347 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT161118 NZ_CP071043:513258-513539 [Bacillus subtilis]
TTGTCTGAATCCAGCGCAAGAACCGAAATGAAAATCAGCTTGCCCGAAAACCTAGTAGCTGAATTGGATGGTGTAGCGAT
GCGGGAGAAACGAAGCAGAAACGAACTGATATCACAAGCAGTGAGAGCGTATGTCAGCGAACGAACAACTCGTCACAACC
GTGATTTGATGAGACGCGGCTATATGGAAATGGCGAAAATCAACCTGAATATTTCTTCTGAGGCTCACTTTGCGGAGTGC
GAGGCTGAAACGACAGTTGAGCGCTTAGTCAGCGGAGGATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GSW7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References